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Annotation rule MF_01059
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General rule information [?]

Accession MF_01059
Dates 1-JUL-2003 (Created)
19-NOV-2019 (Last updated, Version 20)
Name Cyt_trehalase
Scope
Bacteria; Enterobacterales
Template P62601 (TREF_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
TREF
Protein name
RecName: Full=Cytoplasmic trehalase;
EC 3.2.1.28;
AltName: Full=Alpha,alpha-trehalase;
AltName: Full=Alpha,alpha-trehalose glucohydrolase;
Gene name
treF

Comments [?]

Function Hydrolyzes trehalose to glucose. Could be involved, in cells returning to low osmolarity conditions, in the utilization of the accumulated cytoplasmic trehalose, which was synthesized in response to high osmolarity.
Catalytic activity RHEA:32675: alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose
EC 3.2.1.28
Pathway Glycan degradation; trehalose degradation; D-glucose from alpha,alpha-trehalose: step 1/1.
Subunit Monomer.
Subcellular location Cytoplasm.
Similarity Belongs to the glycosyl hydrolase 37 family.

Keywords [?]


Gene Ontology [?]

GO:0004555; Molecular function: alpha,alpha-trehalase activity.
GO:0005991; Biological process: trehalose metabolic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF01204; Trehalase; 1;
PRINTS PR00744; GLHYDRLASE37; 1;
PROSITE PS00927; TREHALASE_1; 1;
PS00928; TREHALASE_2; 1;

Features [?]

From: TREF_ECOLI (P62601)
Key     From     To       Description   Tag   Condition   FTGroup
REGION (Optional)     175     176       Substrate binding     W-D  
REGION (Optional)     221     223       Substrate binding     R-S-Q  
REGION (Optional)     292     294       Substrate binding     R-D-E  
ACT_SITE     326     326       Proton donor/acceptor     D  
ACT_SITE     509     509       Proton donor/acceptor     E  
BINDING (Optional)     168     168       Substrate     R  
BINDING (Optional)     212     212       Substrate     N  
BINDING (Optional)     324     324       Substrate; via carbonyl oxygen     G  
BINDING (Optional)     525     525       Substrate     E  

Additional information [?]

Size range 515-580 amino acids
Related rules MF_01060 (TREA)
Fusion None