HAMAP rule MF_01059
General rule information
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| Accession | MF_01059 |
| Dates | 1-JUL-2003 (Created) 14-MAY-2022 (Last updated, Version 22) |
| Name | Cyt_trehalase |
| Scope | Bacteria; Enterobacterales |
| Template | P62601 (TREF_ECOLI) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Hydrolyzes trehalose to glucose. Could be involved, in cells returning to low osmolarity conditions, in the utilization of the accumulated cytoplasmic trehalose, which was synthesized in response to high osmolarity. |
| Catalytic activity | RHEA:32675: alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose
EC 3.2.1.28 |
| Pathway | Glycan degradation; trehalose degradation; D-glucose from alpha,alpha-trehalose: step 1/1. |
| Subunit | Monomer. |
| Subcellular location | Cytoplasm. |
| Similarity | Belongs to the glycosyl hydrolase 37 family. |
Keywords
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Gene Ontology
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GO:0004555; Molecular function: alpha,alpha-trehalase activity.
GO:0005991; Biological process: trehalose metabolic process.
GO:0005737; Cellular component: cytoplasm.
GO:0005991; Biological process: trehalose metabolic process.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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| Pfam | PF01204; Trehalase; 1; |
| PRINTS | PR00744; GLHYDRLASE37; 1; |
| PROSITE | PS00927; TREHALASE_1; 1; |
| PS00928; TREHALASE_2; 1; |
Features
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| From: TREF_ECOLI (P62601) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING (Optional) | 175 | 176 | /ligand="substrate | W-D | ||||||||
| BINDING (Optional) | 221 | 223 | /ligand="substrate | R-S-Q | ||||||||
| BINDING (Optional) | 292 | 294 | /ligand="substrate | R-D-E | ||||||||
| ACT_SITE | 326 | 326 | Proton donor/acceptor | D | ||||||||
| ACT_SITE | 509 | 509 | Proton donor/acceptor | E | ||||||||
| BINDING (Optional) | 168 | 168 | /ligand="substrate | R | ||||||||
| BINDING (Optional) | 212 | 212 | /ligand="substrate | N | ||||||||
| BINDING (Optional) | 324 | 324 | /ligand="substrate | G | ||||||||
| BINDING (Optional) | 525 | 525 | /ligand="substrate | E | ||||||||
Additional information
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| Size range | 515-580 amino acids |
| Related rules | MF_01060 (TREA) |
| Fusion | None |