HAMAP rule MF_01059
General rule information
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| Accession | MF_01059 |
| Dates | 1-JUL-2003 (Created)
14-MAY-2022 (Last updated, Version 22) |
| Name | Cyt_trehalase |
| Scope(s) |
Bacteria Enterobacterales |
| Template(s) | P62601 (TREF_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01059 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | TREF |
| Protein name | RecName: Full=Cytoplasmic trehalase; EC=3.2.1.28; AltName: Full=Alpha,alpha-trehalase; AltName: Full=Alpha,alpha-trehalose glucohydrolase; |
| Gene name | Name=treF; |
Comments
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| FUNCTION | Hydrolyzes trehalose to glucose. Could be involved, in cells returning to low osmolarity conditions, in the utilization of the accumulated cytoplasmic trehalose, which was synthesized in response to high osmolarity. |
| CATALYTIC ACTIVITY | Reaction=alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D- glucose; Xref=Rhea:RHEA:32675, ChEBI:CHEBI:15377, ChEBI:CHEBI:15903, ChEBI:CHEBI:16551, ChEBI:CHEBI:17925; EC=3.2.1.28; |
| PATHWAY | Glycan degradation; trehalose degradation; D-glucose from alpha,alpha-trehalose: step 1/1. |
| SUBUNIT | Monomer. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the glycosyl hydrolase 37 family. |
Keywords
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Gene Ontology
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| GO:0004555; Molecular function:alpha,alpha-trehalase activity |
| GO:0005991; Biological process:trehalose metabolic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| Pfam | PF01204; Trehalase; 1; |
| PRINTS | PR00744; GLHYDRLASE37; 1; |
| PROSITE | PS00927; TREHALASE_1; 1; |
| PROSITE | PS00928; TREHALASE_2; 1; |
Features
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| From: TREF_ECOLI (P62601) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 175 | 176 | /ligand="substrate" | W-D | ||||||||
| BINDING | 221 | 223 | /ligand="substrate" | R-S-Q | ||||||||
| BINDING | 292 | 294 | /ligand="substrate" | R-D-E | ||||||||
| ACT_SITE | 326 | 326 | /note="Proton donor/acceptor" | D | ||||||||
| ACT_SITE | 509 | 509 | /note="Proton donor/acceptor" | E | ||||||||
| BINDING | 168 | 168 | /ligand="substrate" | R | ||||||||
| BINDING | 212 | 212 | /ligand="substrate" | N | ||||||||
| BINDING | 324 | 324 | /ligand="substrate" | G | ||||||||
| BINDING | 525 | 525 | /ligand="substrate" | E | ||||||||
Additional information
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| Size range | 515-580 amino acids |
| Related rules |
MF_01060 |
| Fusion | Nter: None Cter: None |