HAMAP rule MF_01060

General rule information [?]

Accession	MF_01060
Dates	2-JUL-2003 (Created) 26-JAN-2023 (Last updated, Version 22)

Name	Peripl_trehalase

Scope

Bacteria; Pseudomonadota

Template

P13482 (TREA_ECOLI)

Triggered by

HAMAP; MF_01060 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

TREA

Protein name

RecName:		Full=Periplasmic trehalase;
		EC 3.2.1.28;
AltName:		Full=Alpha,alpha-trehalase;
AltName:		Full=Alpha,alpha-trehalose glucohydrolase;
Flags:		Precursor;

Gene name

treA

Comments [?]

Function	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system.
Catalytic activity	RHEA:32675: alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose EC 3.2.1.28

case <OC:Enterobacterales>

Subunit

Monomer.

end case

Subcellular location	Periplasm.
Similarity	Belongs to the glycosyl hydrolase 37 family.

Keywords [?]

Hydrolase
Glycosidase
Periplasm
Signal

Gene Ontology [?]

GO:0004555; Molecular function: alpha,alpha-trehalase activity.
GO:0005991; Biological process: trehalose metabolic process.
GO:0042597; Cellular component: periplasmic space.

Cross-references [?]

Pfam	PF01204; Trehalase; 1;
PRINTS	PR00744; GLHYDRLASE37; 1;
PROSITE	PS00927; TREHALASE_1; 1;
	PS00928; TREHALASE_2; 1;

Computed features [?]

General

Signal; -; 1; trigger=yes;

Features [?]

From: TREA_ECOLI (P13482)

Key From To Description Tag Condition FTGroup

BINDING 159 160 /ligand="substrate W-D

BINDING 205 207 /ligand="substrate [RH]-S-Q

BINDING 277 279 /ligand="substrate R-[PQ]-E

ACT_SITE 312 312 Proton donor/acceptor D

ACT_SITE 496 496 Proton donor/acceptor E

BINDING 152 152 /ligand="substrate R

BINDING 196 196 /ligand="substrate N

BINDING 310 310 /ligand="substrate G

BINDING 511 511 /ligand="substrate E

Additional information [?]

Size range	520-660 amino acids
Related rules	MF_01059 (TREF)
Fusion	None

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