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Annotation rule MF_01060
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General rule information [?]

Accession MF_01060
Dates 2-JUL-2003 (Created)
19-NOV-2019 (Last updated, Version 19)
Name Peripl_trehalase
Scope
Bacteria; Proteobacteria
Template P13482 (TREA_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
TREA
Protein name
RecName: Full=Periplasmic trehalase;
EC 3.2.1.28;
AltName: Full=Alpha,alpha-trehalase;
AltName: Full=Alpha,alpha-trehalose glucohydrolase;
Flags: Precursor;
Gene name
treA

Comments [?]

Function Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system.
Catalytic activity RHEA:32675: alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose
EC 3.2.1.28
case <OC:Enterobacterales>
Subunit Monomer.
end case
Subcellular location Periplasm.
Similarity Belongs to the glycosyl hydrolase 37 family.

Keywords [?]


Gene Ontology [?]

GO:0004555; Molecular function: alpha,alpha-trehalase activity.
GO:0005991; Biological process: trehalose metabolic process.
GO:0042597; Cellular component: periplasmic space.

Cross-references [?]

Pfam PF01204; Trehalase; 1;
PRINTS PR00744; GLHYDRLASE37; 1;
PROSITE PS00927; TREHALASE_1; 1;
PS00928; TREHALASE_2; 1;

Computed features [?]

General Signal; -; 1; trigger=yes;

Features [?]

From: TREA_ECOLI (P13482)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     159     160       Substrate binding     W-D  
REGION     205     207       Substrate binding     [RH]-S-Q  
REGION     277     279       Substrate binding     R-[PQ]-E  
ACT_SITE     312     312       Proton donor/acceptor     D  
ACT_SITE     496     496       Proton donor/acceptor     E  
BINDING     152     152       Substrate     R  
BINDING     196     196       Substrate     N  
BINDING     310     310       Substrate; via carbonyl oxygen     G  
BINDING     511     511       Substrate     E  

Additional information [?]

Size range 520-660 amino acids
Related rules MF_01059 (TREF)
Fusion None