HAMAP rule MF_01060
General rule information
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| Accession | MF_01060 |
| Dates | 2-JUL-2003 (Created)
28-NOV-2023 (Last updated, Version 23) |
| Name | Peripl_trehalase |
| Scope(s) |
Bacteria Pseudomonadota |
| Template(s) | P13482 (TREA_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01060 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | TREA |
| Protein name | RecName: Full=Periplasmic trehalase; EC=3.2.1.28; AltName: Full=Alpha,alpha-trehalase; AltName: Full=Alpha,alpha-trehalose glucohydrolase; Flags: Precursor; |
| Gene name | Name=treA; |
Comments
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| FUNCTION | Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system. |
| CATALYTIC ACTIVITY | Reaction=alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D- glucose; Xref=Rhea:RHEA:32675, ChEBI:CHEBI:15377, ChEBI:CHEBI:15903, ChEBI:CHEBI:16551, ChEBI:CHEBI:17925; EC=3.2.1.28; |
| case <OC:Enterobacterales> | |
| SUBUNIT | Monomer. |
| end case | |
| SUBCELLULAR LOCATION | Periplasm. |
| SIMILARITY | Belongs to the glycosyl hydrolase 37 family. |
Keywords
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Gene Ontology
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| GO:0004555; Molecular function:alpha,alpha-trehalase activity |
| GO:0005991; Biological process:trehalose metabolic process |
| GO:0042597; Cellular component:periplasmic space |
Cross-references
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| Pfam | PF01204; Trehalase; 1; |
| PRINTS | PR00744; GLHYDRLASE37; 1; |
| PROSITE | PS00927; TREHALASE_1; 1; |
| PROSITE | PS00928; TREHALASE_2; 1; |
| General | Signal; -; 1; |
Features
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| From: TREA_ECOLI (P13482) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 159 | 160 | /ligand="substrate" | W-D | ||||||||
| BINDING | 205 | 207 | /ligand="substrate" | [RH]-S-Q | ||||||||
| BINDING | 277 | 279 | /ligand="substrate" | R-[PQ]-E | ||||||||
| ACT_SITE | 312 | 312 | /note="Proton donor/acceptor" | D | ||||||||
| ACT_SITE | 496 | 496 | /note="Proton donor/acceptor" | E | ||||||||
| BINDING | 152 | 152 | /ligand="substrate" | R | ||||||||
| BINDING | 196 | 196 | /ligand="substrate" | N | ||||||||
| BINDING | 310 | 310 | /ligand="substrate" | G | ||||||||
| BINDING | 511 | 511 | /ligand="substrate" | E | ||||||||
Additional information
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| Size range | 520-660 amino acids |
| Related rules |
MF_01059 |
| Fusion | Nter: None Cter: None |