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HAMAP rule MF_01060

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General rule information [?]

Accession MF_01060
Dates 2-JUL-2003 (Created)
26-JAN-2023 (Last updated, Version 22)
Name Peripl_trehalase
Scope(s) Bacteria
Pseudomonadota
Template(s) P13482 (TREA_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01060 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier TREA
Protein name RecName: Full=Periplasmic trehalase;
                 EC=3.2.1.28;
AltName: Full=Alpha,alpha-trehalase;
AltName: Full=Alpha,alpha-trehalose glucohydrolase;
                 Flags: Precursor;
Gene name Name=treA;

Comments [?]

FUNCTIONProvides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system.
CATALYTIC ACTIVITY Reaction=alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D- glucose; Xref=Rhea:RHEA:32675, ChEBI:CHEBI:15377, ChEBI:CHEBI:15903, ChEBI:CHEBI:16551, ChEBI:CHEBI:17925; EC=3.2.1.28;
case <OC:Enterobacterales>
SUBUNITMonomer.
end case
SUBCELLULAR LOCATIONPeriplasm.
SIMILARITYBelongs to the glycosyl hydrolase 37 family.

Keywords [?]


Gene Ontology [?]

GO:0004555; Molecular function:alpha,alpha-trehalase activity
GO:0005991; Biological process:trehalose metabolic process
GO:0042597; Cellular component:periplasmic space

Cross-references [?]

Pfam PF01204; Trehalase; 1;
PRINTS PR00744; GLHYDRLASE37; 1;
PROSITE PS00927; TREHALASE_1; 1;
PROSITE PS00928; TREHALASE_2; 1;
General Signal; -; 1;

Features [?]

From: TREA_ECOLI (P13482)
Key From To Description Tag Condition FTGroup
BINDING 159 160 /ligand="substrate" W-D
BINDING 205 207 /ligand="substrate" [RH]-S-Q
BINDING 277 279 /ligand="substrate" R-[PQ]-E
ACT_SITE 312 312 /note="Proton donor/acceptor" D
ACT_SITE 496 496 /note="Proton donor/acceptor" E
BINDING 152 152 /ligand="substrate" R
BINDING 196 196 /ligand="substrate" N
BINDING 310 310 /ligand="substrate" G
BINDING 511 511 /ligand="substrate" E

Additional information [?]

Size range 520-660 amino acids
Related rules MF_01059
Fusion Nter: None Cter: None



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