 |
|
Annotation rule MF_01120 |
General rule information
[?]
Accession |
MF_01120 |
Dates |
24-DEC-2003 (Created) 27-APR-2020 (Last updated, Version 33) |
Scope |
Archaea
Bacteria; Chloroflexi
Bacteria; Deinococcus-Thermus |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
case <OC:Sulfolobales>
Protein name |
RecName:
|
Full=[LysW]-lysine/[LysW]-ornithine hydrolase;
|
|
EC 3.5.1.130;
|
|
else case <OC:Archaea> and not <OC:Sulfolobales>
else case <OC:Deinococcus-Thermus>
else case <OC:Chloroflexi>
Protein name |
RecName:
|
Full=Putative [LysW]-lysine hydrolase;
|
|
EC 3.5.1.130;
|
|
end case
case <OC:Archaea>
Function |
Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine. |
else case <OC:Bacteria>
Function |
Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine. |
end case
Catalytic activity |
RHEA:48684: [amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + H2O = [amino-group carrier protein]-C-terminal-L-glutamate + L-lysine
EC 3.5.1.130
|
case <OC:Archaea>
Catalytic activity |
RHEA:52676: [amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate + H2O = [amino-group carrier protein]-C-terminal-L-glutamate + L-ornithine
EC 3.5.1.132
|
end case
Cofactor |
Zn(2+) Co(2+) Note: Binds 2 Zn(2+) or Co(2+) ions per subunit. |
Pathway |
Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 5/5. |
case <OC:Archaea>
Pathway |
Amino-acid biosynthesis; L-arginine biosynthesis. |
end case
Subcellular location |
Cytoplasm. |
Similarity |
Belongs to the peptidase M20A family. LysK subfamily. |
case <OC:Archaea>
end case
GO:0050897; Molecular function: cobalt ion binding.
GO:0008270; Molecular function: zinc ion binding.
GO:0016811; Molecular function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides.
case <OC:Archaea>
GO:0042450; Biological process: arginine biosynthetic process via ornithine.
end case
GO:0019878; Biological process: lysine biosynthetic process via aminoadipic acid.
GO:0005737; Cellular component: cytoplasm.
From: LYSK_THET2 (Q8VUS5) |
Key
|
|
From
|
|
To
|
|
Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
ACT_SITE
|
|
69
|
|
69
|
|
|
|
|
|
D
|
|
|
ACT_SITE
|
|
124
|
|
124
|
|
Proton acceptor
|
|
|
|
E
|
|
|
METAL
|
|
67
|
|
67
|
|
Cobalt or zinc 1
|
|
|
|
H
|
|
|
METAL
|
|
91
|
|
91
|
|
Cobalt or zinc 1
|
|
|
|
D
|
|
|
METAL
|
|
91
|
|
91
|
|
Cobalt or zinc 2
|
|
|
|
D
|
|
|
METAL
|
|
125
|
|
125
|
|
Cobalt or zinc 2
|
|
|
|
E
|
|
|
METAL
|
|
148
|
|
148
|
|
Cobalt or zinc 1
|
|
|
|
E
|
|
|
METAL
|
|
326
|
|
326
|
|
Cobalt or zinc 2
|
|
|
|
H
|
|
|
Additional information
[?]
Size range |
320-425 amino acids |
Related rules |
None |
Fusion |
None |