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Annotation rule MF_01120
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General rule information [?]

Accession MF_01120
Dates 24-DEC-2003 (Created)
27-APR-2020 (Last updated, Version 33)
Name LysK
Scope
Archaea
Bacteria; Chloroflexi
Bacteria; Deinococcus-Thermus
Templates Q8VUS5 (LYSK_THET2); Q4JAP7 (LYSK_SULAC): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
LYSK
case <OC:Sulfolobales>
Protein name
RecName: Full=[LysW]-lysine/[LysW]-ornithine hydrolase;
EC 3.5.1.130;
else case <OC:Archaea> and not <OC:Sulfolobales>
Protein name
RecName: Full=Putative [LysW]-lysine/[LysW]-ornithine hydrolase;
EC 3.5.1.130;
EC 3.5.1.132;
else case <OC:Deinococcus-Thermus>
Protein name
RecName: Full=[LysW]-lysine hydrolase;
EC 3.5.1.130;
else case <OC:Chloroflexi>
Protein name
RecName: Full=Putative [LysW]-lysine hydrolase;
EC 3.5.1.130;
end case
Gene name
lysK

Comments [?]

case <OC:Archaea>
Function Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.
else case <OC:Bacteria>
Function Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine.
end case
Catalytic activity RHEA:48684: [amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + H2O = [amino-group carrier protein]-C-terminal-L-glutamate + L-lysine
EC 3.5.1.130
case <OC:Archaea>
Catalytic activity RHEA:52676: [amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate + H2O = [amino-group carrier protein]-C-terminal-L-glutamate + L-ornithine
EC 3.5.1.132
end case
Cofactor Zn(2+)
Co(2+)
Note: Binds 2 Zn(2+) or Co(2+) ions per subunit.
Pathway Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 5/5.
case <OC:Archaea>
Pathway Amino-acid biosynthesis; L-arginine biosynthesis.
end case
Subcellular location Cytoplasm.
Similarity Belongs to the peptidase M20A family. LysK subfamily.

Keywords [?]

Amino-acid biosynthesis
Cytoplasm
Hydrolase
Lysine biosynthesis
case <OC:Archaea>
Arginine biosynthesis
end case
Metal-binding
Cobalt
Zinc

Gene Ontology [?]

GO:0050897; Molecular function: cobalt ion binding.
GO:0008270; Molecular function: zinc ion binding.
GO:0016811; Molecular function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides.
case <OC:Archaea>
GO:0042450; Biological process: arginine biosynthetic process via ornithine.
end case
GO:0019878; Biological process: lysine biosynthetic process via aminoadipic acid.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF01546; Peptidase_M20; 1;
TIGRFAMs TIGR01902; DapE-lys-deAc; 1;
PROSITE PS00758; ARGE_DAPE_CPG2_1; 1;
PS00759; ARGE_DAPE_CPG2_2; 1;

Features [?]

From: LYSK_THET2 (Q8VUS5)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     69     69             D  
ACT_SITE     124     124       Proton acceptor     E  
METAL     67     67       Cobalt or zinc 1     H  
METAL     91     91       Cobalt or zinc 1     D  
METAL     91     91       Cobalt or zinc 2     D  
METAL     125     125       Cobalt or zinc 2     E  
METAL     148     148       Cobalt or zinc 1     E  
METAL     326     326       Cobalt or zinc 2     H  

Additional information [?]

Size range 320-425 amino acids
Related rules None
Fusion None


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