HAMAP logo

HAMAP rule MF_01124

Send feedback

General rule information [?]

Accession MF_01124
Dates 11-DEC-2003 (Created)
17-JAN-2023 (Last updated, Version 15)
Name MecA
Scope(s) Bacteria
Bacillota
Template(s) P37958 (MECA1_BACSU); [ Recover all ]
Triggered by HAMAP; MF_01124 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MECA
Protein name RecName: Full=Adapter protein MecA;
Gene name Name=mecA;

Comments [?]

case <OC:Bacillaceae>
FUNCTIONEnables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC.
else
FUNCTIONEnables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis.
end case
SUBUNITHomodimer.
case <OC:Bacillaceae>
DOMAINThe N-terminal domain has binding sites for ComK and probably for unfolded/aggregated proteins; the C-terminal domain interacts with ClpC.
else
DOMAINThe N-terminal domain probably binds unfolded/aggregated proteins; the C-terminal domain interacts with ClpC.
end case
SIMILARITYBelongs to the MecA family.

Keywords [?]

case <OC:Bacillaceae>
Competence
Sporulation
end case

Gene Ontology [?]

GO:0030674; Molecular function:protein-macromolecule adaptor activity
case <OCellular component:Bacillaceae>
GO:0045808; Biological process:negative regulation of establishment of competence for transformation
GO:0042174; Biological process:negative regulation of sporulation resulting in formation of a cellular spore
end case

Cross-references [?]

Pfam PF05389; MecA; 1;
PIRSF PIRSF029008; MecA; 1;

Features [?]


Additional information [?]

Size range 192-253 amino acids
Related rules None
Fusion Nter: None Cter: None



View rule in raw text format (no links)