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Annotation rule MF_01124
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General rule information [?]

Accession MF_01124
Dates 11-DEC-2003 (Created)
19-MAR-2020 (Last updated, Version 12)
Name MecA
Scope
Bacteria; Firmicutes
Template P37958 (MECA1_BACSU)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MECA
Protein name
RecName: Full=Adapter protein MecA;
Gene name
mecA

Comments [?]

case <OC:Bacillaceae>
Function Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC.
else
Function Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis.
end case
Subunit Homodimer.
case <OC:Bacillaceae>
Domain The N-terminal domain has binding sites for ComK and probably for unfolded/aggregated proteins; the C-terminal domain interacts with ClpC.
else
Domain The N-terminal domain probably binds unfolded/aggregated proteins; the C-terminal domain interacts with ClpC.
end case
Similarity Belongs to the MecA family.

Keywords [?]

case <OC:Bacillaceae>
end case

Gene Ontology [?]

GO:0030674; Molecular function: protein-macromolecule adaptor activity.
case <OC:Bacillaceae>
GO:0045808; Biological process: negative regulation of establishment of competence for transformation.
GO:0042174; Biological process: negative regulation of sporulation resulting in formation of a cellular spore.
end case

Cross-references [?]

Pfam PF05389; MecA; 1;
PIRSF PIRSF029008; MecA; 1;

Additional information [?]

Size range 192-253 amino acids
Related rules None
Fusion None