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Annotation rule MF_01137
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General rule information [?]

Accession MF_01137
Dates 20-NOV-2003 (Created)
19-NOV-2019 (Last updated, Version 21)
Name CdhA
Scope
Archaea
Templates Q08368 (ACDA1_METTE); Q46G04 (ACDA1_METBF): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
ACDA
Protein name
RecName: Full=Acetyl-CoA decarbonylase/synthase complex subunit alpha;
Short=ACDS complex subunit alpha;
EC 1.2.7.4;
AltName: Full=ACDS complex carbon monoxide dehydrogenase subunit alpha;
Short=ACDS CODH subunit alpha;
Gene name
cdhA

Comments [?]

case <OC:Methanosarcinaceae>
Function Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.
end case
case not <OC:Methanosarcinaceae>
Function Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.
end case
Catalytic activity RHEA:21040: CO + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2 + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
EC 1.2.7.4
Cofactor [4Fe-4S] cluster
Note: Binds 7 [4Fe-4S] clusters per heterotetramer.
[Ni-4Fe-4S] cluster
Note: Binds 2 [Ni-4Fe-4S] clusters per heterotetramer.
case <OC:Methanosarcinaceae>
Pathway One-carbon metabolism; methanogenesis from acetate.
end case
Subunit Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
Domain Cluster B is an all-cysteinyl-liganded 4Fe-4S cluster; cluster C is a mixed Ni-Fe-S cluster which is the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe-4S cluster that bridges the two subunits of the CODH dimer. Contains two additional 4Fe-4S clusters, dubbed E and F, that probably transport electrons from ferredoxin to the B cluster.
Similarity Belongs to the Ni-containing carbon monoxide dehydrogenase family.

Keywords [?]

case <OC:Methanosarcinaceae>
end case
case <FTGroup:3>
end case
case <FTGroup:1> or <FTGroup:2> or <FTGroup:3> or <FTGroup:4> or <FTGroup:5>
end case
case <FTGroup:1> or <FTGroup:2> or <FTGroup:4> or <FTGroup:5>
end case

Gene Ontology [?]

case <FTGroup:1> or <FTGroup:2> or <FTGroup:3> or <FTGroup:4> or <FTGroup:5>
GO:0005506; Molecular function: iron ion binding.
end case
case <FTGroup:3>
GO:0016151; Molecular function: nickel cation binding.
end case
GO:0018492; Molecular function: carbon-monoxide dehydrogenase (acceptor) activity.
case <OC:Methanosarcinaceae>
GO:0019385; Biological process: methanogenesis, from acetate.
end case

Cross-references [?]

Pfam PF00037; Fer4; 2;
PF03063; Prismane; 1;
PRINTS PR00353; 4FE4SFRDOXIN; 1;
TIGRFAMs TIGR00314; CdhA; 1;
PROSITE PS00198; 4FE4S_FER_1; 2;
PS51379; 4FE4S_FER_2; 2; trigger=PRU00711;

Features [?]

From: ACDA1_METBF (Q46G04)
Key     From     To       Description   Tag   Condition   FTGroup
METAL     73     73       Iron-sulfur 1 (4Fe-4S); shared with dimeric partner     C   1
METAL     76     76       Iron-sulfur 2 (4Fe-4S)     C   2
METAL     77     77       Iron-sulfur 1 (4Fe-4S); shared with dimeric partner     C   1
METAL     79     79       Iron-sulfur 2 (4Fe-4S)     C   2
METAL     84     84       Iron-sulfur 2 (4Fe-4S)     C   2
METAL     94     94       Iron-sulfur 2 (4Fe-4S)     C   2
METAL     250     250       Nickel-iron-sulfur (Ni-4Fe-4S); via tele nitrogen     H   3
METAL     278     278       Nickel-iron-sulfur (Ni-4Fe-4S)     C   3
METAL     323     323       Nickel-iron-sulfur (Ni-4Fe-4S)     C   3
METAL     417     417       Iron-sulfur 3 (4Fe-4S)     C   4
METAL     420     420       Iron-sulfur 3 (4Fe-4S)     C   4
METAL     423     423       Iron-sulfur 3 (4Fe-4S)     C   4
METAL     427     427       Iron-sulfur 4 (4Fe-4S)     C   5
METAL     455     455       Iron-sulfur 4 (4Fe-4S)     C   5
METAL     458     458       Iron-sulfur 4 (4Fe-4S)     C   5
METAL     461     461       Iron-sulfur 4 (4Fe-4S)     C   5
METAL     465     465       Iron-sulfur 3 (4Fe-4S)     C   4
METAL     523     523       Nickel-iron-sulfur (Ni-4Fe-4S)     C   3
METAL     552     552       Nickel-iron-sulfur (Ni-4Fe-4S)     C   3
METAL     587     587       Nickel-iron-sulfur (Ni-4Fe-4S)     C   3
BINDING     117     117       Carbon monoxide; via tele nitrogen     H  

Additional information [?]

Size range 632-807 amino acids
Related rules None
Fusion None