HAMAP rule MF_01138
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_01138 |
| Accession | MF_01138 |
| Dates | 28-FEB-2005 (Created)
03-SEP-2024 (Last updated, Version 24) |
| Name | CdhC |
| Scope(s) |
Archaea |
| Template(s) | Q9V2Z4; [ Recover all ] |
| Triggered by |
HAMAP; MF_01138 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | ACDB |
| Protein name | RecName: Full=Acetyl-CoA decarbonylase/synthase complex subunit beta; Short=ACDS complex subunit beta; EC=2.3.1.169; AltName: Full=ACDS complex acyltransferase; |
| Gene name | Name=cdhC; |
Comments
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| case <OC:Methanosarcinaceae> | |
| FUNCTION | Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron- sulfur protein (the gamma-delta complex). |
| end case | |
| case not <OC:Methanosarcinaceae> | |
| FUNCTION | Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex). |
| end case | |
| CATALYTIC ACTIVITY | Reaction=Co(I)-[corrinoid Fe-S protein] + acetyl-CoA + H(+) = methyl- Co(III)-[corrinoid Fe-S protein] + CO + CoA; Xref=Rhea:RHEA:45212, Rhea:RHEA-COMP:11110, Rhea:RHEA-COMP:11111, ChEBI:CHEBI:15378, ChEBI:CHEBI:17245, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:85033, ChEBI:CHEBI:85035; EC=2.3.1.169; |
| COFACTOR | Name=[Ni-Fe-S] cluster; Xref=ChEBI:CHEBI:60400; Note=Binds 1 [Ni-Fe-S] cluster.; |
| case <OC:Methanosarcinaceae> | |
| PATHWAY | One-carbon metabolism; methanogenesis from acetate. |
| end case | |
| SUBUNIT | Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8). |
| SIMILARITY | Belongs to the CdhC family. |
Keywords
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| case <OC:Methanosarcinaceae> | |
| Methanogenesis | |
| end case | |
| Transferase | |
| Acyltransferase | |
| case <FTGroup:1> | |
| Metal-binding | |
| Iron | |
| Nickel | |
| Iron-sulfur | |
| end case | |
Gene Ontology
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| GO:0016407; Molecular function:acetyltransferase activity | |
| case <FTGroup:1> | |
| GO:0005506; Molecular function:iron ion binding | |
| GO:0016151; Molecular function:nickel cation binding | |
| end case | |
| case <OCellular component:Methanosarcinaceae> | |
| GO:0019385; Biological process:methanogenesis, from acetate | |
| end case | |
Cross-references
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Features
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| From: ACDB2_METTE (Q9V2Z4) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 189 | 189 | /ligand="[Ni-Fe-S] cluster" /ligand_id="ChEBI:CHEBI:60400" |
C | 1 | |||||||
| BINDING | 192 | 192 | /ligand="[Ni-Fe-S] cluster" /ligand_id="ChEBI:CHEBI:60400" |
C | 1 | |||||||
| BINDING | 278 | 278 | /ligand="[Ni-Fe-S] cluster" /ligand_id="ChEBI:CHEBI:60400" |
C | 1 | |||||||
| BINDING | 280 | 280 | /ligand="[Ni-Fe-S] cluster" /ligand_id="ChEBI:CHEBI:60400" |
C | 1 | |||||||
Additional information
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| Size range | 460-524 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |