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Annotation rule MF_01138
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General rule information [?]

Accession MF_01138
Dates 20-NOV-2003 (Created)
19-NOV-2019 (Last updated, Version 19)
Name CdhC
Scope
Archaea
Template Q9V2Z4 (ACDB2_METTE)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
ACDB
Protein name
RecName: Full=Acetyl-CoA decarbonylase/synthase complex subunit beta;
Short=ACDS complex subunit beta;
EC 2.3.1.169;
AltName: Full=ACDS complex acyltransferase;
Gene name
cdhC

Comments [?]

case <OC:Methanosarcinaceae>
Function Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex).
end case
case not <OC:Methanosarcinaceae>
Function Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex).
end case
Catalytic activity RHEA:45212: [Co(I) corrinoid Fe-S protein] + acetyl-CoA + H(+) = [methyl-Co(III) corrinoid Fe-S protein] + CO + CoA
EC 2.3.1.169
Cofactor [Ni-Fe-S] cluster
Note: Binds 1 [Ni-Fe-S] cluster.
case <OC:Methanosarcinaceae>
Pathway One-carbon metabolism; methanogenesis from acetate.
end case
Subunit Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
Similarity Belongs to the CdhC family.

Keywords [?]

case <OC:Methanosarcinaceae>
end case
case <FTGroup:1>
end case

Gene Ontology [?]

GO:0016407; Molecular function: acetyltransferase activity.
case <FTGroup:1>
GO:0005506; Molecular function: iron ion binding.
GO:0016151; Molecular function: nickel cation binding.
end case
case <OC:Methanosarcinaceae>
GO:0019385; Biological process: methanogenesis, from acetate.
end case

Cross-references [?]

Pfam PF03598; CdhC; 1;
TIGRFAMs TIGR00316; CdhC; 1;

Features [?]

From: ACDB2_METTE (Q9V2Z4)
Key     From     To       Description   Tag   Condition   FTGroup
COMPBIAS     403     416       Glu-rich        
METAL     189     189       Nickel-iron-sulfur     C   1
METAL     192     192       Nickel-iron-sulfur     C   1
METAL     278     278       Nickel-iron-sulfur     C   1
METAL     280     280       Nickel-iron-sulfur     C   1

Additional information [?]

Size range 460-524 amino acids
Related rules None
Fusion None