HAMAP rule MF_01141

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_01141
Accession	MF_01141
Dates	2-MAR-2004 (Created) 19-NOV-2019 (Last updated, Version 17)
Name	LrgA
Scope(s)	Bacteria Bacillales
Template(s)	P72358 (LRGA_STAA8); [ Recover all ]
Triggered by	HAMAP; MF_01141 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	LRGA
Protein name	RecName: Full=Antiholin-like protein LrgA;
Gene name	Name=lrgA;

Comments [?]

case <OC:Staphylococcus>
FUNCTION	Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like proteins CidA and/or CidB. The LrgAB and CidAB proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses.
else
FUNCTION	Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses.
end case
SUBCELLULAR LOCATION	Cell membrane; Multi-pass membrane protein.
SIMILARITY	Belongs to the CidA/LrgA family. LrgA subfamily.

Keywords [?]

Gene Ontology [?]

GO:0019835; Biological process:cytolysis

GO:0012501; Biological process:programmed cell death

GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam	PF03788; LrgA; 1;
General	Transmembrane; -; 4;

Features [?]

Additional information [?]