Home  |  Contact
Annotation rule MF_01141
Send feedback

General rule information [?]

Accession MF_01141
Dates 2-MAR-2004 (Created)
19-NOV-2019 (Last updated, Version 17)
Name LrgA
Scope
Bacteria; Bacillales
Template P72358 (LRGA_STAA8)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
LRGA
Protein name
RecName: Full=Antiholin-like protein LrgA;
Gene name
lrgA

Comments [?]

case <OC:Staphylococcus>
Function Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like proteins CidA and/or CidB. The LrgAB and CidAB proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses.
else
Function Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses.
end case
Subcellular location Cell membrane; Multi-pass membrane protein.
Similarity Belongs to the CidA/LrgA family. LrgA subfamily.

Keywords [?]


Gene Ontology [?]

GO:0019835; Biological process: cytolysis.
GO:0012501; Biological process: programmed cell death.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF03788; LrgA; 1;

Computed features [?]

General Transmembrane; -; 4; trigger=yes;

Additional information [?]

Size range 143-152 amino acids
Related rules None
Fusion None