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Annotation rule MF_01142 |
Accession | MF_01142 |
Dates | 2-MAR-2004 (Created) 13-JAN-2023 (Last updated, Version 20) |
Name | LrgB |
Scope | Bacteria; Bacillota |
Template | P60643 (LRGB_STAA8) |
Triggered by |
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Function | Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like proteins CidA and/or CidB. The LrgAB and CidAB proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses. |
Function | Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses. |
Subcellular location | Cell membrane; Multi-pass membrane protein. |
Similarity | Belongs to the CidB/LrgB family. LrgB subfamily. |
Pfam | PF04172; LrgB; 1; |
General | Transmembrane; -; 5-7; trigger=yes; |
Size range | 230-233 amino acids |
Related rules | None |
Fusion | None |