HAMAP rule MF_01142
General rule information
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| Accession | MF_01142 |
| Dates | 2-MAR-2004 (Created) 13-JAN-2023 (Last updated, Version 20) |
| Name | LrgB |
| Scope | Bacteria; Bacillota |
| Template | P60643 (LRGB_STAA8) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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case <OC:Staphylococcus>
| Function | Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like proteins CidA and/or CidB. The LrgAB and CidAB proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses. |
else
| Function | Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses. |
end case
| Subcellular location | Cell membrane; Multi-pass membrane protein. |
| Similarity | Belongs to the CidB/LrgB family. LrgB subfamily. |
Keywords
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Gene Ontology
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GO:0019835; Biological process: cytolysis.
GO:0012501; Biological process: programmed cell death.
GO:0005886; Cellular component: plasma membrane.
GO:0012501; Biological process: programmed cell death.
GO:0005886; Cellular component: plasma membrane.
Cross-references
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| Pfam | PF04172; LrgB; 1; |
Computed features
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| General | Transmembrane; -; 5-7; trigger=yes; |
Additional information
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| Size range | 230-233 amino acids |
| Related rules | None |
| Fusion | None |