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HAMAP rule MF_01142

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General rule information [?]

Accession MF_01142
Dates 2-MAR-2004 (Created)
13-JAN-2023 (Last updated, Version 20)
Name LrgB
Scope(s) Bacteria
Bacillota
Template(s) P60643 (LRGB_STAA8); [ Recover all ]
Triggered by HAMAP; MF_01142 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier LRGB
Protein name RecName: Full=Antiholin-like protein LrgB;
Gene name Name=lrgB;

Comments [?]

case <OC:Staphylococcus>
FUNCTIONInhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like proteins CidA and/or CidB. The LrgAB and CidAB proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses.
else
FUNCTIONInhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses.
end case
SUBCELLULAR LOCATIONCell membrane; Multi-pass membrane protein.
SIMILARITYBelongs to the CidB/LrgB family. LrgB subfamily.

Keywords [?]


Gene Ontology [?]

GO:0019835; Biological process:cytolysis
GO:0012501; Biological process:programmed cell death
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF04172; LrgB; 1;
General Transmembrane; -; 5-7;

Features [?]


Additional information [?]

Size range 230-233 amino acids
Related rules None
Fusion Nter: None Cter: None



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