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Annotation rule MF_01142
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General rule information [?]

Accession MF_01142
Dates 2-MAR-2004 (Created)
26-SEP-2014 (Last updated, Version 18)
Name LrgB
Scope
Bacteria; Firmicutes
Template P60643 (LRGB_STAA8)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
LRGB
Protein name
RecName: Full=Antiholin-like protein LrgB;
Gene name
lrgB

Comments [?]

case <OC:Staphylococcus>
Function Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like proteins CidA and/or CidB. The LrgAB and CidAB proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses.
else
Function Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses.
end case
Subcellular location Cell membrane; Multi-pass membrane protein.
Similarity Belongs to the CidB/LrgB family. LrgB subfamily.

Keywords [?]


Gene Ontology [?]

GO:0019835; Biological process: cytolysis.
GO:0012501; Biological process: programmed cell death.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF04172; LrgB; 1;

Computed features [?]

General Transmembrane; -; 5-7; trigger=yes;

Additional information [?]

Size range 230-233 amino acids
Related rules None
Fusion None