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Annotation rule MF_01151
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General rule information [?]

Accession MF_01151
Dates 7-SEP-2004 (Created)
19-NOV-2019 (Last updated, Version 16)
Name GrpE
Scope
Bacteria
Archaea; Euryarchaeota
Template P09372 (GRPE_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
GRPE
Protein name
RecName: Full=Protein GrpE;
AltName: Full=HSP-70 cofactor;
Gene name
grpE

Comments [?]

Function Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
Subunit Homodimer.
Subcellular location Cytoplasm.
Similarity Belongs to the GrpE family.

Keywords [?]


Gene Ontology [?]

GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF01025; GrpE; 1;
PRINTS PR00773; GRPEPROTEIN; 1;
PROSITE PS01071; GRPE; 1;

Additional information [?]

Size range 157-298 amino acids
Related rules None
Fusion None