HAMAP rule MF_01151
General rule information
[?]
| Accession |
MF_01151 |
| Dates |
7-SEP-2004 (Created)
19-NOV-2019 (Last updated, Version 16) |
| Scope |
Bacteria
Archaea; Euryarchaeota |
Propagated annotation
[?]
Identifier, protein and gene names
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| Protein name |
|
RecName:
|
Full=Protein GrpE;
|
|
AltName:
|
Full=HSP-70 cofactor;
|
|
| Function |
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. |
| Subunit |
Homodimer. |
| Subcellular location |
Cytoplasm. |
| Similarity |
Belongs to the GrpE family. |
Additional information
[?]
| Size range |
157-298 amino acids |
| Related rules |
None |
| Fusion |
None |
