HAMAP rule MF_01174
General rule information
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| Accession | MF_01174 |
| Dates | 3-NOV-2006 (Created)
1-JUN-2023 (Last updated, Version 21) |
| Name | Aldedh_AstD |
| Scope(s) |
Bacteria Pseudomonadota |
| Template(s) | P76217 (ASTD_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01174 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | ASTD |
| Protein name | RecName: Full=N-succinylglutamate 5-semialdehyde dehydrogenase; EC=1.2.1.71; AltName: Full=Succinylglutamic semialdehyde dehydrogenase; Short=SGSD; |
| Gene name | Name=astD; |
Comments
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| FUNCTION | Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate. |
| CATALYTIC ACTIVITY | Reaction=H2O + N-succinyl-L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + N-succinyl-L-glutamate + NADH; Xref=Rhea:RHEA:10812, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:58520, ChEBI:CHEBI:58763; EC=1.2.1.71; |
| PATHWAY | Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5. |
| SIMILARITY | Belongs to the aldehyde dehydrogenase family. AstD subfamily. |
Keywords
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Gene Ontology
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| GO:0016491; Molecular function:oxidoreductase activity |
| GO:0019544; Biological process:arginine catabolic process to glutamate |
Cross-references
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| PROSITE | PS00070; ALDEHYDE_DEHYDR_CYS; 1; |
| PROSITE | PS00687; ALDEHYDE_DEHYDR_GLU; 1; |
| Pfam | PF00171; Aldedh; 1; |
| NCBIfam | TIGR03240; arg_catab_astD; 1; |
Features
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| From: ASTD_ECOLI (P76217) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 220 | 225 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
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| ACT_SITE | 243 | 243 | E | |||||||||
| ACT_SITE | 277 | 277 | C | |||||||||
Additional information
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| Size range | 471-505 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |