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HAMAP rule MF_01174

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General rule information [?]

Accession MF_01174
Dates 3-NOV-2006 (Created)
1-JUN-2023 (Last updated, Version 21)
Name Aldedh_AstD
Scope(s) Bacteria
Template(s) P76217 (ASTD_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01174 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ASTD
Protein name RecName: Full=N-succinylglutamate 5-semialdehyde dehydrogenase;
AltName: Full=Succinylglutamic semialdehyde dehydrogenase;
Gene name Name=astD;

Comments [?]

FUNCTIONCatalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.
CATALYTIC ACTIVITY Reaction=H2O + N-succinyl-L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + N-succinyl-L-glutamate + NADH; Xref=Rhea:RHEA:10812, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:58520, ChEBI:CHEBI:58763; EC=;
PATHWAYAmino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5.
SIMILARITYBelongs to the aldehyde dehydrogenase family. AstD subfamily.

Keywords [?]

Gene Ontology [?]

GO:0016491; Molecular function:oxidoreductase activity
GO:0019544; Biological process:arginine catabolic process to glutamate

Cross-references [?]

Pfam PF00171; Aldedh; 1;
NCBIfam TIGR03240; arg_catab_astD; 1;

Features [?]

From: ASTD_ECOLI (P76217)
Key From To Description Tag Condition FTGroup
BINDING 220 225 /ligand="NAD(+)"
ACT_SITE 243 243 E
ACT_SITE 277 277 C

Additional information [?]

Size range 471-505 amino acids
Related rules None
Fusion Nter: None Cter: None

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