HAMAP rule MF_01174

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_01174
Accession	MF_01174
Dates	03-NOV-2006 (Created) 03-SEP-2024 (Last updated, Version 24)
Name	Aldedh_AstD
Scope(s)	Bacteria Pseudomonadota
Template(s)	P76217; [ Recover all ]
Triggered by	HAMAP; MF_01174 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	ASTD
Protein name	RecName: Full=N-succinylglutamate 5-semialdehyde dehydrogenase; EC=1.2.1.71; AltName: Full=Succinylglutamic semialdehyde dehydrogenase; Short=SGSD;
Gene name	Name=astD;

Comments [?]

FUNCTION	Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.
CATALYTIC ACTIVITY	Reaction=N-succinyl-L-glutamate 5-semialdehyde + NAD(+) + H2O = N- succinyl-L-glutamate + NADH + 2 H(+); Xref=Rhea:RHEA:10812, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:58520, ChEBI:CHEBI:58763; EC=1.2.1.71;
PATHWAY	Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5.
SIMILARITY	Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Keywords [?]

Gene Ontology [?]

GO:0016491; Molecular function:oxidoreductase activity

GO:0019544; Biological process:arginine catabolic process to glutamate

GO:0019545; Biological process:arginine catabolic process to succinate

Cross-references [?]

Features [?]

From: ASTD_ECOLI (P76217)

Key

From

Description

Tag

Condition

FTGroup

BINDING

220

225

/ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"

ACT_SITE

243

ACT_SITE

277

Additional information [?]