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Annotation rule MF_01189
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General rule information [?]

Accession MF_01189
Dates 8-JUN-2007 (Created)
19-NOV-2019 (Last updated, Version 16)
Name MFS_NepI
Scope
Bacteria; Enterobacteriaceae
Template P0ADL1 (NEPI_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
NEPI
Protein name
RecName: Full=Purine ribonucleoside efflux pump NepI;
Gene name
nepI

Comments [?]

Function Involved in the efflux of purine ribonucleosides, such as guanosine, adenosine and especially inosine. Involved in the resistance to 6-mercaptopurine.
Subcellular location Cell inner membrane; Multi-pass membrane protein.
Similarity Belongs to the major facilitator superfamily. DHA1 family. NepI (TC 2.A.1.2.26) subfamily.

Keywords [?]


Gene Ontology [?]

GO:0015211; Molecular function: purine nucleoside transmembrane transporter activity.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

PROSITE PS50850; MFS; 1;
Pfam PF07690; MFS_1; 1;

Features [?]

From: NEPI_ECOLI (P0ADL1)
Key     From     To       Description   Tag   Condition   FTGroup
TOPO_DOM     Nter     21       Cytoplasmic        
TRANSMEM     22     42       Helical        
TOPO_DOM     43     54       Periplasmic        
TRANSMEM     55     75       Helical        
TOPO_DOM     76     85       Cytoplasmic        
TRANSMEM     86     106       Helical        
TOPO_DOM     107     107       Periplasmic        
TRANSMEM     108     128       Helical        
TOPO_DOM     129     147       Cytoplasmic        
TRANSMEM     148     168       Helical        
TOPO_DOM     169     175       Periplasmic        
TRANSMEM     176     196       Helical        
TOPO_DOM     197     215       Cytoplasmic        
TRANSMEM     216     236       Helical        
TOPO_DOM     237     255       Periplasmic        
TRANSMEM     256     276       Helical        
TOPO_DOM     277     281       Cytoplasmic        
TRANSMEM     282     302       Helical        
TOPO_DOM     303     305       Periplasmic        
TRANSMEM     306     326       Helical        
TOPO_DOM     327     343       Cytoplasmic        
TRANSMEM     344     364       Helical        
TOPO_DOM     365     366       Periplasmic        
TRANSMEM     367     387       Helical        
TOPO_DOM     388     Cter       Cytoplasmic        

Additional information [?]

Size range 390-455 amino acids
Related rules None
Fusion None