HAMAP rule MF_01189
General rule information
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| Accession | MF_01189 |
| Dates | 8-JUN-2007 (Created)
29-SEP-2022 (Last updated, Version 18) |
| Name | MFS_NepI |
| Scope(s) |
Bacteria Enterobacteriaceae |
| Template(s) | P0ADL1 (NEPI_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01189 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | NEPI |
| Protein name | RecName: Full=Purine ribonucleoside efflux pump NepI; |
| Gene name | Name=nepI; |
Comments
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| FUNCTION | Involved in the efflux of purine ribonucleosides, such as inosine and guanosine. |
| CATALYTIC ACTIVITY | Reaction=H(+)(out) + inosine(in) = H(+)(in) + inosine(out); Xref=Rhea:RHEA:29211, ChEBI:CHEBI:15378, ChEBI:CHEBI:17596; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29212; |
| CATALYTIC ACTIVITY | Reaction=guanosine(in) + H(+)(out) = guanosine(out) + H(+)(in); Xref=Rhea:RHEA:29583, ChEBI:CHEBI:15378, ChEBI:CHEBI:16750; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29584; |
| SUBCELLULAR LOCATION | Cell inner membrane; Multi-pass membrane protein. |
| SIMILARITY | Belongs to the major facilitator superfamily. DHA1 family. NepI (TC 2.A.1.2.26) subfamily. |
Keywords
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Gene Ontology
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| GO:0015211; Molecular function:purine nucleoside transmembrane transporter activity |
| GO:0005886; Cellular component:plasma membrane |
Cross-references
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Features
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| From: NEPI_ECOLI (P0ADL1) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| TOPO_DOM | Nter | 21 | /note="Cytoplasmic" | |||||||||
| TRANSMEM | 22 | 42 | /note="Helical" | |||||||||
| TOPO_DOM | 43 | 54 | /note="Periplasmic" | |||||||||
| TRANSMEM | 55 | 75 | /note="Helical" | |||||||||
| TOPO_DOM | 76 | 85 | /note="Cytoplasmic" | |||||||||
| TRANSMEM | 86 | 106 | /note="Helical" | |||||||||
| TOPO_DOM | 107 | 107 | /note="Periplasmic" | |||||||||
| TRANSMEM | 108 | 128 | /note="Helical" | |||||||||
| TOPO_DOM | 129 | 147 | /note="Cytoplasmic" | |||||||||
| TRANSMEM | 148 | 168 | /note="Helical" | |||||||||
| TOPO_DOM | 169 | 175 | /note="Periplasmic" | |||||||||
| TRANSMEM | 176 | 196 | /note="Helical" | |||||||||
| TOPO_DOM | 197 | 215 | /note="Cytoplasmic" | |||||||||
| TRANSMEM | 216 | 236 | /note="Helical" | |||||||||
| TOPO_DOM | 237 | 255 | /note="Periplasmic" | |||||||||
| TRANSMEM | 256 | 276 | /note="Helical" | |||||||||
| TOPO_DOM | 277 | 281 | /note="Cytoplasmic" | |||||||||
| TRANSMEM | 282 | 302 | /note="Helical" | |||||||||
| TOPO_DOM | 303 | 305 | /note="Periplasmic" | |||||||||
| TRANSMEM | 306 | 326 | /note="Helical" | |||||||||
| TOPO_DOM | 327 | 343 | /note="Cytoplasmic" | |||||||||
| TRANSMEM | 344 | 364 | /note="Helical" | |||||||||
| TOPO_DOM | 365 | 366 | /note="Periplasmic" | |||||||||
| TRANSMEM | 367 | 387 | /note="Helical" | |||||||||
| TOPO_DOM | 388 | Cter | /note="Cytoplasmic" | |||||||||
Additional information
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| Size range | 390-455 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |