HAMAP rule MF_01208
General rule information
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| Accession | MF_01208 |
| Dates | 30-MAY-2002 (Created) 19-NOV-2022 (Last updated, Version 36) |
| Name | PyrE |
| Scope | Bacteria
Archaea |
| Templates | P0A7E3 (PYRE_ECOLI); P08870 (PYRE_SALTY); P42719 (PYRE_RHILT); P61498 (PYRE_THET2); P46534 (PYRE_BACCL): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). |
| Catalytic activity | RHEA:10380: diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate
EC 2.4.2.10 |
| Cofactor | Mg(2+) |
| Pathway | Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. |
| Subunit | Homodimer. |
| Similarity | Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily. |
Keywords
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Gene Ontology
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GO:0000287; Molecular function: magnesium ion binding.
GO:0004588; Molecular function: orotate phosphoribosyltransferase activity.
GO:0006221; Biological process: pyrimidine nucleotide biosynthetic process.
GO:0004588; Molecular function: orotate phosphoribosyltransferase activity.
GO:0006221; Biological process: pyrimidine nucleotide biosynthetic process.
Cross-references
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| Pfam | PF00156; Pribosyltran; 1; |
| TIGRFAMs | TIGR00336; PyrE; 1; |
| TIGR01367; PyrE_Therm; 1; | |
| PROSITE | PS00103; PUR_PYR_PR_TRANSFER; 1; |
Features
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case <OC:Bacteria>
| From: PYRE_SALTY (P08870) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING (Optional) | 34 | 35 | /ligand="orotate" /ligand_id="ChEBI:CHEBI:30839 | F-F | ||||||||
| BINDING (Optional) | 72 | 73 | /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017" /ligand_note="ligand shared between dimeric partners" /note="in other chain | Y-K | ||||||||
| BINDING | 124 | 132 | /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017" /ligand_note="ligand shared between dimeric partners" /note="in other chain | |||||||||
| BINDING (Optional) | 26 | 26 | /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017" /ligand_note="ligand shared between dimeric partners" /note="in other chain | [KR] | ||||||||
| BINDING (Optional) | 99 | 99 | /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017" /ligand_note="ligand shared between dimeric partners | R | ||||||||
| BINDING (Optional) | 100 | 100 | /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017" /ligand_note="ligand shared between dimeric partners" /note="in other chain | K | ||||||||
| BINDING (Optional) | 103 | 103 | /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017" /ligand_note="ligand shared between dimeric partners | K | ||||||||
| BINDING (Optional) | 105 | 105 | /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017" /ligand_note="ligand shared between dimeric partners | H | ||||||||
| BINDING (Optional) | 128 | 128 | /ligand="orotate" /ligand_id="ChEBI:CHEBI:30839 | [ST] | ||||||||
| BINDING (Optional) | 156 | 156 | /ligand="orotate" /ligand_id="ChEBI:CHEBI:30839 | R | ||||||||
end case
case <OC:Archaea>
| From: PYRE_PYRHO (O58855) | ||||||||||||
| BINDING | 119 | 127 | /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017" /ligand_note="ligand shared between dimeric partners" /note="in other chain | |||||||||
| BINDING (Optional) | 93 | 93 | /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017" /ligand_note="ligand shared between dimeric partners | R | ||||||||
| BINDING (Optional) | 94 | 94 | /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017" /ligand_note="ligand shared between dimeric partners" /note="in other chain | K | ||||||||
| BINDING (Optional) | 97 | 97 | /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017" /ligand_note="ligand shared between dimeric partners | [KR] | ||||||||
| BINDING (Optional) | 99 | 99 | /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017" /ligand_note="ligand shared between dimeric partners | H | ||||||||
| BINDING (Optional) | 123 | 123 | /ligand="orotate" /ligand_id="ChEBI:CHEBI:30839 | T | ||||||||
| BINDING (Optional) | 151 | 151 | /ligand="orotate" /ligand_id="ChEBI:CHEBI:30839 | R | ||||||||
end case
Additional information
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| Size range | 166-237 amino acids |
| Related rules | MF_01214 (PYREL) |
| Fusion | Nter: MF_01200 (pyrF); Cter: None |