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Annotation rule MF_01208 |
Accession | MF_01208 |
Dates | 30-MAY-2002 (Created) 19-NOV-2019 (Last updated, Version 32) |
Name | PyrE |
Scope | Bacteria
Archaea |
Templates | P0A7E3 (PYRE_ECOLI); P08870 (PYRE_SALTY); P42719 (PYRE_RHILT); P61498 (PYRE_THET2); P46534 (PYRE_BACCL): [Recover all] |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Function | Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). |
Catalytic activity | RHEA:10380: diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate
EC 2.4.2.10 |
Cofactor | Mg(2+) |
Pathway | Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. |
Subunit | Homodimer. |
Similarity | Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily. |
Pfam | PF00156; Pribosyltran; 1; |
TIGRFAMs | TIGR00336; PyrE; 1; |
TIGR01367; PyrE_Therm; 1; | |
PROSITE | PS00103; PUR_PYR_PR_TRANSFER; 1; |
From: PYRE_SALTY (P08870) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
REGION (Optional) | 34 | 35 | Orotate binding | F-F | ||||||||
REGION (Optional) | 72 | 73 | 5-phosphoribose 1-diphosphate binding | Y-K | ||||||||
REGION | 124 | 132 | 5-phosphoribose 1-diphosphate binding | |||||||||
BINDING (Optional) | 26 | 26 | 5-phosphoribose 1-diphosphate | [KR] | ||||||||
BINDING (Optional) | 99 | 99 | 5-phosphoribose 1-diphosphate; shared with dimeric partner | R | ||||||||
BINDING (Optional) | 100 | 100 | 5-phosphoribose 1-diphosphate | K | ||||||||
BINDING (Optional) | 103 | 103 | 5-phosphoribose 1-diphosphate; shared with dimeric partner | K | ||||||||
BINDING (Optional) | 105 | 105 | 5-phosphoribose 1-diphosphate; shared with dimeric partner | H | ||||||||
BINDING (Optional) | 128 | 128 | Orotate | [ST] | ||||||||
BINDING (Optional) | 156 | 156 | Orotate | R |
From: PYRE_PYRHO (O58855) | ||||||||||||
REGION | 119 | 127 | 5-phosphoribose 1-diphosphate binding | |||||||||
BINDING (Optional) | 93 | 93 | 5-phosphoribose 1-diphosphate; shared with dimeric partner | R | ||||||||
BINDING (Optional) | 94 | 94 | 5-phosphoribose 1-diphosphate | K | ||||||||
BINDING (Optional) | 97 | 97 | 5-phosphoribose 1-diphosphate; shared with dimeric partner | [KR] | ||||||||
BINDING (Optional) | 99 | 99 | 5-phosphoribose 1-diphosphate; shared with dimeric partner | H | ||||||||
BINDING (Optional) | 123 | 123 | Orotate | T | ||||||||
BINDING (Optional) | 151 | 151 | Orotate | R |
Size range | 166-237 amino acids |
Related rules | MF_01214 (PYREL) |
Fusion | Nter: MF_01200 (pyrF); Cter: None |