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Annotation rule MF_01225 |
Accession | MF_01225 |
Dates | 13-SEP-2002 (Created) 19-NOV-2019 (Last updated, Version 31) |
Name | MoaA |
Scope | Bacteria
Archaea |
Templates | P69848 (MOAA_STAA8); Q44118 (MOAA_PAENI); P30745 (MOAA_ECOLI); Q9X5W3 (MOAA_RHOCA): [Recover all] |
Triggered by |
Triggered by |
Identifier |
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Protein name |
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Protein name |
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Gene name |
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Function | Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate. |
Catalytic activity | RHEA:49576: AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine
EC 4.1.99.22 |
Cofactor | [4Fe-4S] cluster Note: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate. |
Pathway | Cofactor biosynthesis; molybdopterin biosynthesis. |
Subunit | Monomer and homodimer. |
Similarity | Belongs to the radical SAM superfamily. MoaA family. |
PROSITE | PS01305; MOAA_NIFB_PQQE; 1; |
Pfam | PF06463; Mob_synth_C; 1; |
PF04055; Radical_SAM; 1; | |
TIGRFAMs | TIGR02666; MoaA; 1; |
TIGR02668; moaA_archaeal; 1; |
From: MOAA_STAA8 (P69848) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
NP_BIND | 266 | 268 | GTP | [RK]-x-R | ||||||||
METAL | 24 | 24 | Iron-sulfur 1 (4Fe-4S-S-AdoMet) | C | ||||||||
METAL | 28 | 28 | Iron-sulfur 1 (4Fe-4S-S-AdoMet) | C | ||||||||
METAL | 31 | 31 | Iron-sulfur 1 (4Fe-4S-S-AdoMet) | C | ||||||||
METAL | 261 | 261 | Iron-sulfur 2 (4Fe-4S-substrate) | C | ||||||||
METAL | 264 | 264 | Iron-sulfur 2 (4Fe-4S-substrate) | C | ||||||||
METAL | 278 | 278 | Iron-sulfur 2 (4Fe-4S-substrate) | C | ||||||||
BINDING | 17 | 17 | GTP | R | ||||||||
BINDING | 30 | 30 | S-adenosyl-L-methionine | Y | ||||||||
BINDING | 71 | 71 | GTP | R | ||||||||
BINDING | 75 | 75 | S-adenosyl-L-methionine; via carbonyl oxygen | G | ||||||||
BINDING | 102 | 102 | GTP | [TS] | ||||||||
BINDING | 126 | 126 | S-adenosyl-L-methionine | S | ||||||||
BINDING | 163 | 163 | GTP | K | ||||||||
BINDING | 197 | 197 | S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygen | M |
From: MOAA_PYRAB (Q9V2G2) | ||||||||||||
NP_BIND | 255 | 257 | GTP | R-x-R | ||||||||
METAL | 21 | 21 | Iron-sulfur 1 (4Fe-4S-S-AdoMet) | C | ||||||||
METAL | 25 | 25 | Iron-sulfur 1 (4Fe-4S-S-AdoMet) | C | ||||||||
METAL | 28 | 28 | Iron-sulfur 1 (4Fe-4S-S-AdoMet) | C | ||||||||
METAL | 250 | 250 | Iron-sulfur 2 (4Fe-4S-substrate) | C | ||||||||
METAL | 253 | 253 | Iron-sulfur 2 (4Fe-4S-substrate) | C | ||||||||
METAL | 267 | 267 | Iron-sulfur 2 (4Fe-4S-substrate) | C | ||||||||
BINDING | 14 | 14 | GTP | R | ||||||||
BINDING (Optional) | 27 | 27 | S-adenosyl-L-methionine | Y | ||||||||
BINDING | 61 | 61 | GTP | [KR] | ||||||||
BINDING | 65 | 65 | S-adenosyl-L-methionine; via carbonyl oxygen | G | ||||||||
BINDING | 90 | 90 | GTP | T | ||||||||
BINDING | 114 | 114 | S-adenosyl-L-methionine | S | ||||||||
BINDING | 150 | 150 | GTP | K | ||||||||
BINDING (Optional) | 189 | 189 | S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygen | M |
Size range | 318-378 amino acids |
Size range | 296-357 amino acids |
Related rules | None |
Fusion | None |