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Annotation rule MF_01225 |
Accession | MF_01225 |
Dates | 13-SEP-2002 (Created) 14-MAY-2022 (Last updated, Version 33) |
Name | MoaA |
Scope | Bacteria
Archaea |
Templates | P69848 (MOAA_STAA8); Q44118 (MOAA_PAENI); P30745 (MOAA_ECOLI); Q9X5W3 (MOAA_RHOCA): [Recover all] |
Triggered by |
Triggered by |
Identifier |
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Protein name |
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Protein name |
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Gene name |
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Function | Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate. |
Catalytic activity | RHEA:49576: AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine
EC 4.1.99.22 |
Cofactor | [4Fe-4S] cluster Note: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate. |
Pathway | Cofactor biosynthesis; molybdopterin biosynthesis. |
Subunit | Monomer and homodimer. |
Similarity | Belongs to the radical SAM superfamily. MoaA family. |
PROSITE | PS01305; MOAA_NIFB_PQQE; 1; |
Pfam | PF06463; Mob_synth_C; 1; |
PF04055; Radical_SAM; 1; | |
TIGRFAMs | TIGR02666; MoaA; 1; |
TIGR02668; moaA_archaeal; 1; |
From: MOAA_STAA8 (P69848) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 266 | 268 | /ligand="GTP" /ligand_id="37565 | [RK]-x-R | ||||||||
BINDING | 24 | 24 | /ligand="[4Fe-4S] cluster" /ligand_id="49883" /ligand_label="1" /ligand_note="4Fe-4S-S-AdoMet | C | ||||||||
BINDING | 28 | 28 | /ligand="[4Fe-4S] cluster" /ligand_id="49883" /ligand_label="1" /ligand_note="4Fe-4S-S-AdoMet | C | ||||||||
BINDING | 31 | 31 | /ligand="[4Fe-4S] cluster" /ligand_id="49883" /ligand_label="1" /ligand_note="4Fe-4S-S-AdoMet | C | ||||||||
BINDING | 261 | 261 | /ligand="[4Fe-4S] cluster" /ligand_id="49883" /ligand_label="2" /ligand_note="4Fe-4S-substrate | C | ||||||||
BINDING | 264 | 264 | /ligand="[4Fe-4S] cluster" /ligand_id="49883" /ligand_label="2" /ligand_note="4Fe-4S-substrate | C | ||||||||
BINDING | 278 | 278 | /ligand="[4Fe-4S] cluster" /ligand_id="49883" /ligand_label="2" /ligand_note="4Fe-4S-substrate | C | ||||||||
BINDING | 17 | 17 | /ligand="GTP" /ligand_id="37565 | R | ||||||||
BINDING | 30 | 30 | /ligand="S-adenosyl-L-methionine" /ligand_id="59789 | Y | ||||||||
BINDING | 71 | 71 | /ligand="GTP" /ligand_id="37565 | R | ||||||||
BINDING | 75 | 75 | /ligand="S-adenosyl-L-methionine" /ligand_id="59789 | G | ||||||||
BINDING | 102 | 102 | /ligand="GTP" /ligand_id="37565 | [TS] | ||||||||
BINDING | 126 | 126 | /ligand="S-adenosyl-L-methionine" /ligand_id="59789 | S | ||||||||
BINDING | 163 | 163 | /ligand="GTP" /ligand_id="37565 | K | ||||||||
BINDING | 197 | 197 | /ligand="S-adenosyl-L-methionine" /ligand_id="59789 | M |
From: MOAA_PYRAB (Q9V2G2) | ||||||||||||
BINDING | 255 | 257 | /ligand="GTP" /ligand_id="37565 | R-x-R | ||||||||
BINDING | 21 | 21 | /ligand="[4Fe-4S] cluster" /ligand_id="49883" /ligand_label="1" /ligand_note="4Fe-4S-S-AdoMet | C | ||||||||
BINDING | 25 | 25 | /ligand="[4Fe-4S] cluster" /ligand_id="49883" /ligand_label="1" /ligand_note="4Fe-4S-S-AdoMet | C | ||||||||
BINDING | 28 | 28 | /ligand="[4Fe-4S] cluster" /ligand_id="49883" /ligand_label="1" /ligand_note="4Fe-4S-S-AdoMet | C | ||||||||
BINDING | 250 | 250 | /ligand="[4Fe-4S] cluster" /ligand_id="49883" /ligand_label="2" /ligand_note="4Fe-4S-substrate | C | ||||||||
BINDING | 253 | 253 | /ligand="[4Fe-4S] cluster" /ligand_id="49883" /ligand_label="2" /ligand_note="4Fe-4S-substrate | C | ||||||||
BINDING | 267 | 267 | /ligand="[4Fe-4S] cluster" /ligand_id="49883" /ligand_label="2" /ligand_note="4Fe-4S-substrate | C | ||||||||
BINDING | 14 | 14 | /ligand="GTP" /ligand_id="37565 | R | ||||||||
BINDING (Optional) | 27 | 27 | /ligand="S-adenosyl-L-methionine" /ligand_id="59789 | Y | ||||||||
BINDING | 61 | 61 | /ligand="GTP" /ligand_id="37565 | [KR] | ||||||||
BINDING | 65 | 65 | /ligand="S-adenosyl-L-methionine" /ligand_id="59789 | G | ||||||||
BINDING | 90 | 90 | /ligand="GTP" /ligand_id="37565 | T | ||||||||
BINDING | 114 | 114 | /ligand="S-adenosyl-L-methionine" /ligand_id="59789 | S | ||||||||
BINDING | 150 | 150 | /ligand="GTP" /ligand_id="37565 | K | ||||||||
BINDING (Optional) | 189 | 189 | /ligand="S-adenosyl-L-methionine" /ligand_id="59789 | M |
Size range | 318-378 amino acids |
Size range | 296-357 amino acids |
Related rules | None |
Fusion | None |