HAMAP rule MF_01277

General rule information [?]

Accession	MF_01277
Dates	9-FEB-2007 (Created) 19-NOV-2022 (Last updated, Version 19)
Name	HTH_type_PurR
Scope(s)	Bacteria Gammaproteobacteria
Template(s)	P0ACP7 (PURR_ECOLI); [ Recover all ]
Triggered by	HAMAP; MF_01277 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	PURR
Protein name	RecName: Full=HTH-type transcriptional repressor PurR; AltName: Full=Pur regulon repressor; AltName: Full=Purine nucleotide synthesis repressor;
Gene name	Name=purR;

Comments [?]

FUNCTION	Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression.
PATHWAY	Purine metabolism; purine nucleotide biosynthesis [regulation].
SUBUNIT	Homodimer.
DOMAIN	Consists of two structural and functional domains: an N- terminal DNA-binding domain, approximately the first 60 residues, and a larger C-terminal domain, approximately 280 residues, which imparts the function of corepressor binding and oligomerization.

Keywords [?]

Gene Ontology [?]

GO:0045892; Biological process:negative regulation of DNA-templated transcription

Cross-references [?]

Features [?]

From: PURR_ECOLI (P0ACP7)

Key

From

Description

Tag

Condition

FTGroup

DNA_BIND

/note="H-T-H motif"

DNA_BIND

BINDING