HAMAP rule MF_01277

General rule information [?]

Accession	MF_01277
Dates	9-FEB-2007 (Created) 19-NOV-2022 (Last updated, Version 19)

Name	HTH_type_PurR

Scope

Bacteria; Gammaproteobacteria

Template

P0ACP7 (PURR_ECOLI)

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

PURR

Protein name

RecName:		Full=HTH-type transcriptional repressor PurR;
AltName:		Full=Pur regulon repressor;
AltName:		Full=Purine nucleotide synthesis repressor;

Gene name

purR

Comments [?]

Function	Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression.
Pathway	Purine metabolism; purine nucleotide biosynthesis [regulation].
Subunit	Homodimer.
Domain	Consists of two structural and functional domains: an N-terminal DNA-binding domain, approximately the first 60 residues, and a larger C-terminal domain, approximately 280 residues, which imparts the function of corepressor binding and oligomerization.

Keywords [?]

Gene Ontology [?]

GO:0045892; Biological process: negative regulation of DNA-templated transcription.

Cross-references [?]

Features [?]

From: PURR_ECOLI (P0ACP7)

Key From To Description Tag Condition FTGroup

DNA_BIND 4 23 H-T-H motif

DNA_BIND 48 56

BINDING 73 73 /ligand="hypoxanthine" /ligand_id="ChEBI:CHEBI:17368 [YF]

BINDING 190 190 /ligand="hypoxanthine" /ligand_id="ChEBI:CHEBI:17368 [RK]

BINDING (Optional) 192 192 /ligand="hypoxanthine" /ligand_id="ChEBI:CHEBI:17368 T

BINDING 221 221 /ligand="hypoxanthine" /ligand_id="ChEBI:CHEBI:17368 F

BINDING 275 275 /ligand="hypoxanthine" /ligand_id="ChEBI:CHEBI:17368 D

Additional information [?]