HAMAP rule MF_01277
General rule information
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Accession | MF_01277 |
Dates | 9-FEB-2007 (Created)
19-NOV-2022 (Last updated, Version 19) |
Name | HTH_type_PurR |
Scope(s) |
Bacteria Gammaproteobacteria |
Template(s) | P0ACP7 (PURR_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_01277 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | PURR |
Protein name | RecName: Full=HTH-type transcriptional repressor PurR; AltName: Full=Pur regulon repressor; AltName: Full=Purine nucleotide synthesis repressor; |
Gene name | Name=purR; |
Comments
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FUNCTION | Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression. |
PATHWAY | Purine metabolism; purine nucleotide biosynthesis [regulation]. |
SUBUNIT | Homodimer. |
DOMAIN | Consists of two structural and functional domains: an N- terminal DNA-binding domain, approximately the first 60 residues, and a larger C-terminal domain, approximately 280 residues, which imparts the function of corepressor binding and oligomerization. |
Keywords
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Gene Ontology
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GO:0045892; Biological process:negative regulation of DNA-templated transcription |
Cross-references
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PROSITE | PS00356; HTH_LACI_1; 1; |
PROSITE | PS50932; HTH_LACI_2; 1; |
Pfam | PF00356; LacI; 1; |
Pfam | PF00532; Peripla_BP_1; 1; |
PRINTS | PR00036; HTHLACI; 1; |
Features
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From: PURR_ECOLI (P0ACP7) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DNA_BIND | 4 | 23 | /note="H-T-H motif" | |||||||||
DNA_BIND | 48 | 56 | ||||||||||
BINDING | 73 | 73 | /ligand="hypoxanthine" /ligand_id="ChEBI:CHEBI:17368" |
[YF] | ||||||||
BINDING | 190 | 190 | /ligand="hypoxanthine" /ligand_id="ChEBI:CHEBI:17368" |
[RK] | ||||||||
BINDING | 192 | 192 | /ligand="hypoxanthine" /ligand_id="ChEBI:CHEBI:17368" |
T | ||||||||
BINDING | 221 | 221 | /ligand="hypoxanthine" /ligand_id="ChEBI:CHEBI:17368" |
F | ||||||||
BINDING | 275 | 275 | /ligand="hypoxanthine" /ligand_id="ChEBI:CHEBI:17368" |
D |
Additional information
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Size range | 333-341 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |