HAMAP rule MF_01280

General rule information [?]

Accession	MF_01280
Dates	1-OCT-2007 (Created) 19-NOV-2019 (Last updated, Version 13)
Name	Diacylglyc_glucosyltr
Scope(s)	Bacteria Bacillales
Template(s)	P54166 (UGTP_BACSU); Q5HH69 (UGTP_STAAC); Q2FZP7 (UGTP_STAA8); [ Recover all ]
Triggered by	HAMAP; MF_01280 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	UGTP
case <OC:Bacillus>
Protein name	RecName: Full=Processive diacylglycerol beta-glucosyltransferase; EC=2.4.1.315; AltName: Full=Beta-diglucosyldiacylglycerol synthase; Short=Beta-DGS; Short=DGlcDAG synthase; Short=Glc2-DAG synthase; AltName: Full=Beta-gentiobiosyldiacylglycerol synthase; AltName: Full=Beta-monoglucosyldiacylglycerol synthase; Short=Beta-MGS; Short=MGlcDAG synthase; AltName: Full=Beta-triglucosyldiacylglycerol synthase; Short=TGlcDAG synthase; AltName: Full=Diglucosyl diacylglycerol synthase (1,6-linking); AltName: Full=Glucosyl-beta-1,6-glucosyldiacylglycerol synthase; AltName: Full=UDP glucosyltransferase; AltName: Full=UDP-glucose:1,2-diacylglycerol-3-beta-D-glucosyltransferase;
else
Protein name	RecName: Full=Processive diacylglycerol beta-glucosyltransferase; EC=2.4.1.315; AltName: Full=Beta-diglucosyldiacylglycerol synthase; Short=Beta-DGS; Short=DGlcDAG synthase; Short=Glc2-DAG synthase; AltName: Full=Beta-gentiobiosyldiacylglycerol synthase; AltName: Full=Beta-monoglucosyldiacylglycerol synthase; Short=Beta-MGS; Short=MGlcDAG synthase; AltName: Full=Diglucosyl diacylglycerol synthase (1,6-linking); AltName: Full=Glucosyl-beta-1,6-glucosyldiacylglycerol synthase; AltName: Full=UDP glucosyltransferase; AltName: Full=UDP-glucose:1,2-diacylglycerol-3-beta-D-glucosyltransferase;
end case
Gene name	Name=ugtP;

Comments [?]

case <OC:Bacillus>
FUNCTION	Processive glucosyltransferase involved in the biosynthesis of both the bilayer- and non-bilayer-forming membrane glucolipids. Is able to successively transfer up to three glucosyl residues to diacylglycerol (DAG), thereby catalyzing the formation of beta- monoglucosyl-DAG (3-O-(beta-D-glucopyranosyl)-1,2-diacyl-sn-glycerol), beta-diglucosyl-DAG (3-O-(beta-D-glucopyranosyl-beta-(1->6)-D- glucopyranosyl)-1,2-diacyl-sn-glycerol) and beta-triglucosyl-DAG (3-O- (beta-D-glucopyranosyl-beta-(1->6)-D-glucopyranosyl-beta-(1->6)-D- glucopyranosyl)-1,2-diacyl-sn-glycerol). Beta-diglucosyl-DAG is the predominant glycolipid found in Bacillales and is also used as a membrane anchor for lipoteichoic acid (LTA).
else
FUNCTION	Processive glucosyltransferase involved in the biosynthesis of both the bilayer- and non-bilayer-forming membrane glucolipids. Is able to successively transfer two glucosyl residues to diacylglycerol (DAG), thereby catalyzing the formation of beta-monoglucosyl-DAG (3-O- (beta-D-glucopyranosyl)-1,2-diacyl-sn-glycerol) and beta-diglucosyl-DAG (3-O-(beta-D-glucopyranosyl-beta-(1->6)-D-glucopyranosyl)-1,2-diacyl- sn-glycerol). Beta-diglucosyl-DAG is the predominant glycolipid found in Bacillales and is also used as a membrane anchor for lipoteichoic acid (LTA).
end case
CATALYTIC ACTIVITY	Reaction=a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + UDP- alpha-D-glucose = a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn- glycerol + H(+) + UDP; Xref=Rhea:RHEA:39031, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:58885, ChEBI:CHEBI:75799, ChEBI:CHEBI:76264; EC=2.4.1.315;
CATALYTIC ACTIVITY	Reaction=a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose = a 1,2-diacyl- 3-O-(beta-D-glucopyranosyl)-sn-glycerol + H(+) + UDP; Xref=Rhea:RHEA:17285, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:58223, ChEBI:CHEBI:58885, ChEBI:CHEBI:75799;
case <OC:Bacillus>
CATALYTIC ACTIVITY	Reaction=a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + UDP-alpha-D-glucose = a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc- (1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP; Xref=Rhea:RHEA:39027, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:58885, ChEBI:CHEBI:76264, ChEBI:CHEBI:76265; EC=2.4.1.315;
end case
PATHWAY	Glycolipid metabolism; diglucosyl-diacylglycerol biosynthesis.
SUBCELLULAR LOCATION	Cell membrane.
SIMILARITY	Belongs to the glycosyltransferase 28 family. UgtP subfamily.

Keywords [?]

Carbohydrate metabolism

Glycosyltransferase

Lipid biosynthesis

Lipid metabolism

Gene Ontology [?]

GO:0035251; Molecular function:UDP-glucosyltransferase activity

GO:0047228; Molecular function:1,2-diacylglycerol 3-glucosyltransferase activity

GO:0009247; Biological process:glycolipid biosynthetic process

GO:0070395; Biological process:lipoteichoic acid biosynthetic process

Cross-references [?]

Pfam	PF00534; Glycos_transf_1; 1;
Pfam	PF06925; MGDG_synth; 1;
Pfam	PF04101; Glyco_tran_28_C; 1;

Features [?]

Additional information [?]

Size range	382-391 amino acids
Related rules	None
Fusion	Nter: None Cter: None

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