HAMAP rule MF_01293
General rule information
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Accession | MF_01293 |
Dates | 5-NOV-2008 (Created) 1-JUN-2023 (Last updated, Version 14) |
Name | TagBP_aldolase_KbaY |
Scope | Bacteria; Enterobacterales |
Templates | P0AB74 (KBAY_ECOLI); Q9KIP8 (KBAY_ECOLX): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalytic subunit of the tagatose-1,6-bisphosphate aldolase KbaYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6-bisphosphate (TBP). Requires KbaZ subunit for full activity and stability. |
Catalytic activity | RHEA:22948: D-tagatofuranose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate
EC 4.1.2.40 |
case <FTGroup:1>
Cofactor | Zn(2+) Note: Binds 1 zinc ion per subunit. |
end case
Pathway | Carbohydrate metabolism; D-tagatose 6-phosphate degradation; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate: step 2/2. |
Subunit | Homotetramer. Forms a complex with KbaZ. |
Similarity | Belongs to the class II fructose-bisphosphate aldolase family. TagBP aldolase KbaY subfamily. |
Keywords
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case <FTGroup:1>
end case
Gene Ontology
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case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
end case
GO:0009025; Molecular function: tagatose-bisphosphate aldolase activity.
GO:0005975; Biological process: carbohydrate metabolic process.
GO:0005975; Biological process: carbohydrate metabolic process.
Cross-references
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PROSITE | PS00602; ALDOLASE_CLASS_II_1; 1; |
PS00806; ALDOLASE_CLASS_II_2; 1; | |
Pfam | PF01116; F_bP_aldolase; 1; |
NCBIfam | TIGR00167; CbbA; 1; |
TIGR01858; Tag_bisphos_ald; 1; |
Features
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From: KBAY_ECOLI (P0AB74) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 230 | 233 | /ligand="dihydroxyacetone phosphate" /ligand_id="ChEBI:CHEBI:57642 | N-x-A-T | ||||||||
BINDING | 209 | 211 | /ligand="dihydroxyacetone phosphate" /ligand_id="ChEBI:CHEBI:57642 | G-x-S | ||||||||
ACT_SITE | 82 | 82 | Proton donor | D | ||||||||
BINDING | 83 | 83 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic | H | 1 | |||||||
BINDING | 180 | 180 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic | H | 1 | |||||||
BINDING | 208 | 208 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic | H | 1 | |||||||
BINDING | 181 | 181 | /ligand="dihydroxyacetone phosphate" /ligand_id="ChEBI:CHEBI:57642 | G |
Additional information
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Size range | 286-292 amino acids |
Related rules | MF_01294 (GATY) |
Fusion | None |
Comments | Subunit kbaZ is described in MF_01295. In some enterobacteria, a second D-tagatose-1,6-bisphosphate aldolase is present: gatYZ (MF_01294 and MF_01296). |