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Annotation rule MF_01293 |
General rule information
[?]
Accession |
MF_01293 |
Dates |
5-NOV-2008 (Created) 19-NOV-2019 (Last updated, Version 10) |
Scope |
Bacteria; Enterobacterales |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Protein name |
RecName:
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Full=D-tagatose-1,6-bisphosphate aldolase subunit KbaY;
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Short=TBPA;
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Short=TagBP aldolase;
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EC 4.1.2.40;
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AltName:
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Full=D-tagatose-bisphosphate aldolase class II;
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AltName:
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Full=Ketose 1,6-bisphosphate aldolase class II;
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AltName:
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Full=Tagatose-bisphosphate aldolase;
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Function |
Catalytic subunit of the tagatose-1,6-bisphosphate aldolase KbaYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6-bisphosphate (TBP). Requires KbaZ subunit for full activity and stability. |
Catalytic activity |
RHEA:22948: D-tagatofuranose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate
EC 4.1.2.40
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case <FTGroup:1>
Cofactor |
Zn(2+) Note: Binds 1 zinc ion per subunit. |
end case
Pathway |
Carbohydrate metabolism; D-tagatose 6-phosphate degradation; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate: step 2/2. |
Subunit |
Homotetramer. Forms a complex with KbaZ. |
Similarity |
Belongs to the class II fructose-bisphosphate aldolase family. TagBP aldolase KbaY subfamily. |
case <FTGroup:1>
end case
case <FTGroup:1>
end case
GO:0009025; Molecular function: tagatose-bisphosphate aldolase activity.
GO:0005975; Biological process: carbohydrate metabolic process.
From: KBAY_ECOLI (P0AB74) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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REGION
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230
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233
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Dihydroxyacetone phosphate binding
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N-x-A-T
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REGION
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209
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211
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Dihydroxyacetone phosphate binding
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G-x-S
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ACT_SITE
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82
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82
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Proton donor
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D
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METAL
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83
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83
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Zinc; catalytic
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H
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1
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METAL
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180
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180
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Zinc; catalytic
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H
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1
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METAL
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208
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208
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Zinc; catalytic
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H
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1
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BINDING
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181
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181
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Dihydroxyacetone phosphate; via amide nitrogen
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G
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Additional information
[?]
Size range |
286-292 amino acids |
Related rules |
MF_01294 (GATY) |
Fusion |
None |
Comments |
Subunit kbaZ is described in MF_01295. In some enterobacteria, a second D-tagatose-1,6-bisphosphate aldolase is present: gatYZ (MF_01294 and MF_01296). |