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HAMAP rule MF_01293

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General rule information [?]

Accession MF_01293
Dates 5-NOV-2008 (Created)
1-JUN-2023 (Last updated, Version 14)
Name TagBP_aldolase_KbaY
Scope
Bacteria; Enterobacterales
Templates P0AB74 (KBAY_ECOLI); Q9KIP8 (KBAY_ECOLX): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
KBAY
Protein name
RecName: Full=D-tagatose-1,6-bisphosphate aldolase subunit KbaY;
Short=TBPA;
Short=TagBP aldolase;
EC 4.1.2.40;
AltName: Full=D-tagatose-bisphosphate aldolase class II;
AltName: Full=Ketose 1,6-bisphosphate aldolase class II;
AltName: Full=Tagatose-bisphosphate aldolase;
Gene name
kbaY

Comments [?]

Function Catalytic subunit of the tagatose-1,6-bisphosphate aldolase KbaYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6-bisphosphate (TBP). Requires KbaZ subunit for full activity and stability.
Catalytic activity RHEA:22948: D-tagatofuranose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate
EC 4.1.2.40
case <FTGroup:1>
Cofactor Zn(2+)
Note: Binds 1 zinc ion per subunit.
end case
Pathway Carbohydrate metabolism; D-tagatose 6-phosphate degradation; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate: step 2/2.
Subunit Homotetramer. Forms a complex with KbaZ.
Similarity Belongs to the class II fructose-bisphosphate aldolase family. TagBP aldolase KbaY subfamily.

Keywords [?]

Lyase
case <FTGroup:1>
Metal-binding
Zinc
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
end case
GO:0009025; Molecular function: tagatose-bisphosphate aldolase activity.
GO:0005975; Biological process: carbohydrate metabolic process.

Cross-references [?]

PROSITE PS00602; ALDOLASE_CLASS_II_1; 1;
PS00806; ALDOLASE_CLASS_II_2; 1;
Pfam PF01116; F_bP_aldolase; 1;
NCBIfam TIGR00167; CbbA; 1;
TIGR01858; Tag_bisphos_ald; 1;

Features [?]

From: KBAY_ECOLI (P0AB74)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     230     233       /ligand="dihydroxyacetone phosphate" /ligand_id="ChEBI:CHEBI:57642     N-x-A-T  
BINDING     209     211       /ligand="dihydroxyacetone phosphate" /ligand_id="ChEBI:CHEBI:57642     G-x-S  
ACT_SITE     82     82       Proton donor     D  
BINDING     83     83       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic     H   1
BINDING     180     180       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic     H   1
BINDING     208     208       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic     H   1
BINDING     181     181       /ligand="dihydroxyacetone phosphate" /ligand_id="ChEBI:CHEBI:57642     G  

Additional information [?]

Size range 286-292 amino acids
Related rules MF_01294 (GATY)
Fusion None
Comments Subunit kbaZ is described in MF_01295. In some enterobacteria, a second D-tagatose-1,6-bisphosphate aldolase is present: gatYZ (MF_01294 and MF_01296).


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