HAMAP logo
Due to maintenance work, this service will be unavailable Tuesday 16 between 06:00 and 06:30 - CEST. Apologies for the inconvenience.

HAMAP rule MF_01293

Send feedback

General rule information [?]

Accession MF_01293
Dates 5-NOV-2008 (Created)
1-JUN-2023 (Last updated, Version 14)
Name TagBP_aldolase_KbaY
Scope(s) Bacteria
Enterobacterales
Template(s) P0AB74 (KBAY_ECOLI); Q9KIP8 (KBAY_ECOLX); [ Recover all ]
Triggered by HAMAP; MF_01293 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier KBAY
Protein name RecName: Full=D-tagatose-1,6-bisphosphate aldolase subunit KbaY;
                 Short=TBPA;
                 Short=TagBP aldolase;
                 EC=4.1.2.40;
AltName: Full=D-tagatose-bisphosphate aldolase class II;
AltName: Full=Ketose 1,6-bisphosphate aldolase class II;
AltName: Full=Tagatose-bisphosphate aldolase;
Gene name Name=kbaY;

Comments [?]

FUNCTIONCatalytic subunit of the tagatose-1,6-bisphosphate aldolase KbaYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6-bisphosphate (TBP). Requires KbaZ subunit for full activity and stability.
CATALYTIC ACTIVITY Reaction=D-tagatofuranose 1,6-bisphosphate = D-glyceraldehyde 3- phosphate + dihydroxyacetone phosphate; Xref=Rhea:RHEA:22948, ChEBI:CHEBI:57642, ChEBI:CHEBI:58694, ChEBI:CHEBI:59776; EC=4.1.2.40;
case <FTGroup:1>
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
end case
PATHWAYCarbohydrate metabolism; D-tagatose 6-phosphate degradation; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6- phosphate: step 2/2.
SUBUNITHomotetramer. Forms a complex with KbaZ.
SIMILARITYBelongs to the class II fructose-bisphosphate aldolase family. TagBP aldolase KbaY subfamily.

Keywords [?]

Lyase
case <FTGroup:1>
Metal-binding
Zinc
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0008270; Molecular function:zinc ion binding
end case
GO:0009025; Molecular function:tagatose-bisphosphate aldolase activity
GO:0005975; Biological process:carbohydrate metabolic process

Cross-references [?]

PROSITE PS00602; ALDOLASE_CLASS_II_1; 1;
PROSITE PS00806; ALDOLASE_CLASS_II_2; 1;
Pfam PF01116; F_bP_aldolase; 1;
NCBIfam TIGR00167; CbbA; 1;
NCBIfam TIGR01858; Tag_bisphos_ald; 1;

Features [?]

From: KBAY_ECOLI (P0AB74)
Key From To Description Tag Condition FTGroup
BINDING 230 233 /ligand="dihydroxyacetone phosphate"
/ligand_id="ChEBI:CHEBI:57642"
N-x-A-T
BINDING 209 211 /ligand="dihydroxyacetone phosphate"
/ligand_id="ChEBI:CHEBI:57642"
G-x-S
ACT_SITE 82 82 /note="Proton donor" D
BINDING 83 83 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_note="catalytic"
H 1
BINDING 180 180 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_note="catalytic"
H 1
BINDING 208 208 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_note="catalytic"
H 1
BINDING 181 181 /ligand="dihydroxyacetone phosphate"
/ligand_id="ChEBI:CHEBI:57642"
G

Additional information [?]

Size range 286-292 amino acids
Related rules MF_01294
Fusion Nter: None Cter: None
Comments Subunit kbaZ is described in MF_01295. In some enterobacteria, a second D-tagatose-1,6-bisphosphate aldolase is present: gatYZ (MF_01294 and MF_01296).



View rule in raw text format (no links)