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HAMAP rule MF_01367

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General rule information [?]

Accession MF_01367
Dates 20-NOV-2006 (Created)
1-JUN-2023 (Last updated, Version 21)
Name Ribosomal_L14
Scope
Bacteria
Archaea
Plastid
Templates Q9RXJ2 (RL14_DEIRA); P0ADY3 (RL14_ECOLI); Q5SHP8 (RL14_THET8); P22450 (RL14_HALMA): [Recover all]
case <OC:Bacteria> or <OC:Archaea> or <OG:Chloroplast>
Triggered by
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

case <OC:Bacteria> and not <OC:Cyanobacteriota>
Identifier
RL14
Protein name
RecName: Full=Large ribosomal subunit protein uL14;
Gene name
rplN
else case <OC:Cyanobacteriota>
Identifier
RL14
Protein name
RecName: Full=Large ribosomal subunit protein uL14;
Gene name
rplN, rpl14
else case <OC:Archaea>
Identifier
RL14
Protein name
RecName: Full=Large ribosomal subunit protein uL14;
Gene name
rpl14
else case <OG:Chloroplast>
Identifier
RK14
Protein name
RecName: Full=Large ribosomal subunit protein uL14c;
Gene name
rpl14
end case

Comments [?]

case <OC:Bacteria>
Function Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
Subunit Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.
else case <OC:Archaea>
Function Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
Subunit Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.
else case <OG:Chloroplast>
Function Binds to 23S rRNA.
Subunit Part of the 50S ribosomal subunit.
Subcellular location Plastid, chloroplast.
end case
Similarity Belongs to the universal ribosomal protein uL14 family.

Keywords [?]

Ribonucleoprotein
Ribosomal protein
RNA-binding
rRNA-binding

Gene Ontology [?]

GO:0019843; Molecular function: rRNA binding.
GO:0006412; Biological process: translation.
case <OG:Chloroplast>
GO:0009507; Cellular component: chloroplast.
end case

Cross-references [?]

PROSITE PS00049; RIBOSOMAL_L14; 1;
Pfam PF00238; Ribosomal_L14; 1;
NCBIfam TIGR01067; RplN_bact; 1;
TIGR03673; rpl14p_arch; 1;

Additional information [?]

Size range 119-182 amino acids
Related rules None
Fusion None
Comments In E.coli interaction of L14 with ribosomal silencing factor RsfS has been shown block formation of bridge B8, preventing association of 2 ribosomal subunits and thus causes ribosomal silencing. The same interaction is suspected to have the same effect in human mitochondrial ribosomes and maybe maize chloroplasts as well. It has not yet been propagated to all ribosomal proteins while waiting further experimental confirmation.


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