HAMAP rule MF_01418
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_01418 |
| Accession | MF_01418 |
| Dates | 5-MAR-2004 (Created)
2-SEP-2024 (Last updated, Version 25) |
| Name | SpeB |
| Scope(s) |
Bacteria Neisseriales Enterobacterales |
| Template(s) | P60651 (SPEB_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01418 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | SPEB |
| Protein name | RecName: Full=Agmatinase; EC=3.5.3.11; AltName: Full=Agmatine ureohydrolase; Short=AUH; |
| Gene name | Name=speB; |
Comments
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| FUNCTION | Catalyzes the formation of putrescine from agmatine. |
| CATALYTIC ACTIVITY | Reaction=agmatine + H2O = urea + putrescine; Xref=Rhea:RHEA:13929, ChEBI:CHEBI:15377, ChEBI:CHEBI:16199, ChEBI:CHEBI:58145, ChEBI:CHEBI:326268; EC=3.5.3.11; |
| COFACTOR | Name=Mn(2+); Xref=ChEBI:CHEBI:29035; |
| PATHWAY | Amine and polyamine biosynthesis; putrescine biosynthesis via agmatine pathway; putrescine from agmatine: step 1/1. |
| SIMILARITY | Belongs to the arginase family. Agmatinase subfamily. |
Keywords
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| Polyamine biosynthesis |
| Spermidine biosynthesis |
| Putrescine biosynthesis |
| Hydrolase |
| Metal-binding |
| Manganese |
Gene Ontology
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| GO:0008783; Molecular function:agmatinase activity |
| GO:0033388; Biological process:putrescine biosynthetic process from arginine |
| GO:0008295; Biological process:spermidine biosynthetic process |
Cross-references
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| Pfam | PF00491; Arginase; 1; |
| NCBIfam | TIGR01230; Agmatinase; 1; |
| PROSITE | PS01053; ARGINASE_1; 1; |
| PROSITE | PS51409; ARGINASE_2; 1; |
Features
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| From: SPEB_ECOLI (P60651) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 126 | 126 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" |
H | ||||||||
| BINDING | 149 | 149 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" |
D | ||||||||
| BINDING | 151 | 151 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" |
H | ||||||||
| BINDING | 153 | 153 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" |
D | ||||||||
| BINDING | 230 | 230 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" |
D | ||||||||
| BINDING | 232 | 232 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" |
D | ||||||||
Additional information
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| Size range | 303-322 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | This protein has not been found in Yersinia pestis. |