HAMAP rule MF_01418
General rule information
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Accession | MF_01418 |
Dates | 5-MAR-2004 (Created) 1-JUN-2023 (Last updated, Version 23) |
Name | SpeB |
Scope | Bacteria; Neisseriales
Bacteria; Enterobacterales |
Template | P60651 (SPEB_ECOLI) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the formation of putrescine from agmatine. |
Catalytic activity | RHEA:13929: agmatine + H2O = putrescine + urea
EC 3.5.3.11 |
Cofactor | Mn(2+) |
Pathway | Amine and polyamine biosynthesis; putrescine biosynthesis via agmatine pathway; putrescine from agmatine: step 1/1. |
Similarity | Belongs to the arginase family. Agmatinase subfamily. |
Keywords
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Polyamine biosynthesis
Spermidine biosynthesis
Putrescine biosynthesis
Hydrolase
Metal-binding
Manganese
Spermidine biosynthesis
Putrescine biosynthesis
Hydrolase
Metal-binding
Manganese
Gene Ontology
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GO:0008783; Molecular function: agmatinase activity.
GO:0009446; Biological process: putrescine biosynthetic process.
GO:0008295; Biological process: spermidine biosynthetic process.
GO:0009446; Biological process: putrescine biosynthetic process.
GO:0008295; Biological process: spermidine biosynthetic process.
Cross-references
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Pfam | PF00491; Arginase; 1; |
NCBIfam | TIGR01230; Agmatinase; 1; |
PROSITE | PS01053; ARGINASE_1; 1; |
PS51409; ARGINASE_2; 1; |
Features
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From: SPEB_ECOLI (P60651) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 126 | 126 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035 | H | ||||||||
BINDING | 149 | 149 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035 | D | ||||||||
BINDING | 151 | 151 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035 | H | ||||||||
BINDING | 153 | 153 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035 | D | ||||||||
BINDING | 230 | 230 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035 | D | ||||||||
BINDING | 232 | 232 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035 | D |
Additional information
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Size range | 303-322 amino acids |
Related rules | None |
Fusion | None |
Comments | This protein has not been found in Yersinia pestis. |