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HAMAP rule MF_01418

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General rule information [?]

Accession MF_01418
Dates 5-MAR-2004 (Created)
1-JUN-2023 (Last updated, Version 23)
Name SpeB
Scope(s) Bacteria
Neisseriales
Enterobacterales
Template(s) P60651 (SPEB_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01418 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier SPEB
Protein name RecName: Full=Agmatinase;
                 EC=3.5.3.11;
AltName: Full=Agmatine ureohydrolase;
                 Short=AUH;
Gene name Name=speB;

Comments [?]

FUNCTIONCatalyzes the formation of putrescine from agmatine.
CATALYTIC ACTIVITY Reaction=agmatine + H2O = putrescine + urea; Xref=Rhea:RHEA:13929, ChEBI:CHEBI:15377, ChEBI:CHEBI:16199, ChEBI:CHEBI:58145, ChEBI:CHEBI:326268; EC=3.5.3.11;
COFACTOR Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
PATHWAYAmine and polyamine biosynthesis; putrescine biosynthesis via agmatine pathway; putrescine from agmatine: step 1/1.
SIMILARITYBelongs to the arginase family. Agmatinase subfamily.

Keywords [?]


Gene Ontology [?]

GO:0008783; Molecular function:agmatinase activity
GO:0009446; Biological process:putrescine biosynthetic process
GO:0008295; Biological process:spermidine biosynthetic process

Cross-references [?]

Pfam PF00491; Arginase; 1;
NCBIfam TIGR01230; Agmatinase; 1;
PROSITE PS01053; ARGINASE_1; 1;
PROSITE PS51409; ARGINASE_2; 1;

Features [?]

From: SPEB_ECOLI (P60651)
Key From To Description Tag Condition FTGroup
BINDING 126 126 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
H
BINDING 149 149 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
D
BINDING 151 151 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
H
BINDING 153 153 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
D
BINDING 230 230 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
D
BINDING 232 232 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
D

Additional information [?]

Size range 303-322 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments This protein has not been found in Yersinia pestis.



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