HAMAP rule MF_01418

General rule information [?]

Accession	MF_01418
Dates	5-MAR-2004 (Created) 1-JUN-2023 (Last updated, Version 23)

Name

SpeB

Scope

Bacteria; Neisseriales

Bacteria; Enterobacterales

Template

P60651 (SPEB_ECOLI)

Triggered by

HAMAP; MF_01418 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

SPEB

Protein name

RecName:		Full=Agmatinase;
		EC 3.5.3.11;
AltName:		Full=Agmatine ureohydrolase;
		Short=AUH;

Gene name

speB

Comments [?]

Function	Catalyzes the formation of putrescine from agmatine.
Catalytic activity	RHEA:13929: agmatine + H2O = putrescine + urea EC 3.5.3.11
Cofactor	Mn(2+)
Pathway	Amine and polyamine biosynthesis; putrescine biosynthesis via agmatine pathway; putrescine from agmatine: step 1/1.
Similarity	Belongs to the arginase family. Agmatinase subfamily.

Keywords [?]

Polyamine biosynthesis
Spermidine biosynthesis
Putrescine biosynthesis
Hydrolase
Metal-binding
Manganese

Gene Ontology [?]

GO:0008783; Molecular function: agmatinase activity.
GO:0009446; Biological process: putrescine biosynthetic process.
GO:0008295; Biological process: spermidine biosynthetic process.

Cross-references [?]

Pfam	PF00491; Arginase; 1;
NCBIfam	TIGR01230; Agmatinase; 1;
PROSITE	PS01053; ARGINASE_1; 1;
	PS51409; ARGINASE_2; 1;

Features [?]

From: SPEB_ECOLI (P60651)

Key From To Description Tag Condition FTGroup

BINDING 126 126 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035 H

BINDING 149 149 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035 D

BINDING 151 151 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035 H

BINDING 153 153 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035 D

BINDING 230 230 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035 D

BINDING 232 232 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035 D

Additional information [?]

Size range	303-322 amino acids
Related rules	None
Fusion	None
Comments	This protein has not been found in Yersinia pestis.

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