HAMAP rule MF_01441
General rule information
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| Accession | MF_01441 |
| Dates | 27-NOV-2006 (Created)
19-NOV-2022 (Last updated, Version 20) |
| Name | Dps |
| Scope(s) |
Bacteria Gammaproteobacteria |
| Template(s) | P0ABT2 (DPS_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01441 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | DPS |
| Protein name | RecName: Full=DNA protection during starvation protein; EC=1.16.-.-; |
| Gene name | Name=dps; |
Comments
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| case <OC:Escherichia> or <OC:Shigella> | |
| FUNCTION | During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co-crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction. Dps also protects the cell from UV and gamma irradiation, iron and copper toxicity, thermal stress and acid and base shocks. Also shows a weak catalase activity. |
| end case | |
| case not <OC:Escherichia> and not <OC:Shigella> | |
| FUNCTION | During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co-crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction. |
| end case | |
| CATALYTIC ACTIVITY | Reaction=2 Fe(2+) + 2 H(+) + H2O2 = 2 Fe(3+) + 2 H2O; Xref=Rhea:RHEA:48712, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16240, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034; |
| SUBUNIT | Homododecamer. The 12 subunits form a hollow sphere into which the mineral iron core of up to 500 Fe(3+) can be deposited. |
| case <OC:Escherichia> or <OC:Shigella> | |
| SUBCELLULAR LOCATION | Cytoplasm, nucleoid. |
| end case | |
| case not <OC:Escherichia> and not <OC:Shigella> | |
| SUBCELLULAR LOCATION | Cytoplasm. |
| end case | |
| SIMILARITY | Belongs to the Dps family. |
Keywords
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Gene Ontology
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| GO:0008199; Molecular function:ferric iron binding |
| GO:0003677; Molecular function:DNA binding |
| GO:0016491; Molecular function:oxidoreductase activity |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| PROSITE | PS00818; DPS_1; 1; |
| PROSITE | PS00819; DPS_2; 1; |
| Pfam | PF00210; Ferritin; 1; |
| PRINTS | PR01346; HELNAPAPROT; 1; |
Features
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| From: DPS_ECOLI (P0ABT2) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Escherichia> or <OC:Shigella> | ||||||||||||
| BINDING | 51 | 51 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1" /ligand_note="ligand shared between two dodecameric partners" |
H | ||||||||
| BINDING | 78 | 78 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1" /ligand_note="ligand shared between two dodecameric partners" /note="in other chain" |
D | ||||||||
| BINDING | 82 | 82 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1" /ligand_note="ligand shared between two dodecameric partners" /note="in other chain" |
E | ||||||||
| BINDING | 82 | 82 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="2" |
E | ||||||||
| end case | ||||||||||||
| case not <OC:Escherichia> and not <OC:Shigella> | ||||||||||||
| BINDING | 51 | 51 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" |
H | ||||||||
| BINDING | 78 | 78 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" |
D | ||||||||
| BINDING | 82 | 82 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" |
E | ||||||||
| end case | ||||||||||||
Additional information
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| Size range | 166-169 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |