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Annotation rule MF_01441
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General rule information [?]

Accession MF_01441
Dates 27-NOV-2006 (Created)
19-NOV-2019 (Last updated, Version 17)
Name Dps
Scope
Bacteria; Gammaproteobacteria
Template P0ABT2 (DPS_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
DPS
Protein name
RecName: Full=DNA protection during starvation protein;
EC 1.16.-.-;
Gene name
dps

Comments [?]

case <OC:Escherichia> or <OC:Shigella>
Function During stationary phase, binds the chromosome non-specifically, forming a highly ordered and stable dps-DNA co-crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction. Dps also protects the cell from UV and gamma irradiation, iron and copper toxicity, thermal stress and acid and base shocks. Also shows a weak catalase activity.
end case
case not <OC:Escherichia> and not <OC:Shigella>
Function During stationary phase, binds the chromosome non-specifically, forming a highly ordered and stable dps-DNA co-crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction.
end case
Catalytic activity RHEA:48712: 2 Fe(2+) + 2 H(+) + H2O2 = 2 Fe(3+) + 2 H2O
Subunit Homododecamer. The 12 subunits form a hollow sphere into which the mineral iron core of up to 500 Fe(3+) can be deposited.
case <OC:Escherichia> or <OC:Shigella>
Subcellular location Cytoplasm, nucleoid.
end case
case not <OC:Escherichia> and not <OC:Shigella>
Subcellular location Cytoplasm.
end case
Similarity Belongs to the Dps family.

Keywords [?]


Gene Ontology [?]

GO:0008199; Molecular function: ferric iron binding.
GO:0003677; Molecular function: DNA binding.
GO:0016491; Molecular function: oxidoreductase activity.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

PROSITE PS00818; DPS_1; 1;
PS00819; DPS_2; 1;
Pfam PF00210; Ferritin; 1;
PRINTS PR01346; HELNAPAPROT; 1;

Features [?]

case <OC:Escherichia> or <OC:Shigella>
From: DPS_ECOLI (P0ABT2)
Key     From     To       Description   Tag   Condition   FTGroup
METAL     51     51       Iron 1; shared with neighboring subunit     H  
METAL     78     78       Iron 1     D  
METAL     82     82       Iron 1     E  
METAL     82     82       Iron 2     E  
end case
case not <OC:Escherichia> and not <OC:Shigella>
METAL     51     51       Iron     H  
METAL     78     78       Iron     D  
METAL     82     82       Iron     E  
end case

Additional information [?]

Size range 166-169 amino acids
Related rules None
Fusion None