HAMAP rule MF_01498
General rule information
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| Accession | MF_01498 |
| Dates | 11-FEB-2016 (Created)
1-JUN-2023 (Last updated, Version 6) |
| Name | RadA_bact |
| Scope(s) |
Bacteria |
| Template(s) | P24554 (RADA_ECOLI); P37572 (RADA_BACSU); Q9RVC4 (RADA_DEIRA); Q8DRP0 (RADA_STRR6); [ Recover all ] |
| Triggered by |
HAMAP; MF_01498 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | RADA |
| Protein name | RecName: Full=DNA repair protein RadA; |
| Gene name | Name=radA; |
Comments
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| FUNCTION | Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks. |
| case <FT:1> | |
| DOMAIN | Has a putative N-terminal zinc-finger, a middle region with homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease. |
| else | |
| DOMAIN | The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease. |
| end case | |
| SIMILARITY | Belongs to the RecA family. RadA subfamily. |
Keywords
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| ATP-binding | |
| DNA damage | |
| DNA repair | |
| DNA-binding | |
| Metal-binding | |
| Nucleotide-binding | |
| Stress response | |
| case <FT:1> | |
| Zinc | |
| Zinc-finger | |
| end case | |
Gene Ontology
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| GO:0000725; Biological process:recombinational repair |
| GO:0005524; Molecular function:ATP binding |
Cross-references
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| PROSITE | PS50162; RECA_2; 1; |
| Pfam | PF05362; Lon_C; 1; |
| PRINTS | PR01874; DNAREPAIRADA; 1; |
| NCBIfam | TIGR00416; sms; 1; |
Features
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| From: RADA_ECOLI (P24554) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ZN_FING | 11 | 28 | /note="C4-type" | C-x(2)-C-x(10)-C-x(2)-C | ||||||||
| BINDING | 102 | 109 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
[GAS]-x-P-G-x-G-K-[ST] | ||||||||
| REGION | 357 | Cter | /note="Lon-protease-like" | |||||||||
| MOTIF | 258 | 262 | /note="RadA KNRFG motif" | K-N-R-[FY]-G | ||||||||
Additional information
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| Size range | 420-505 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | A number of Streptococcus pneumoniae do not encode the possible zinc-finger. Not a homolog of the archaeal RadA protein. |