HAMAP rule MF_01498
General rule information
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Accession | MF_01498 |
Dates | 11-FEB-2016 (Created)
1-JUN-2023 (Last updated, Version 6) |
Name | RadA_bact |
Scope(s) |
Bacteria |
Template(s) | P24554 (RADA_ECOLI); P37572 (RADA_BACSU); Q9RVC4 (RADA_DEIRA); Q8DRP0 (RADA_STRR6); [ Recover all ] |
Triggered by |
HAMAP; MF_01498 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | RADA |
Protein name | RecName: Full=DNA repair protein RadA; |
Gene name | Name=radA; |
Comments
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FUNCTION | Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks. |
case <FT:1> | |
DOMAIN | Has a putative N-terminal zinc-finger, a middle region with homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease. |
else | |
DOMAIN | The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease. |
end case | |
SIMILARITY | Belongs to the RecA family. RadA subfamily. |
Keywords
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ATP-binding | |
DNA damage | |
DNA repair | |
DNA-binding | |
Metal-binding | |
Nucleotide-binding | |
Stress response | |
case <FT:1> | |
Zinc | |
Zinc-finger | |
end case |
Gene Ontology
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GO:0000725; Biological process:recombinational repair |
GO:0005524; Molecular function:ATP binding |
Cross-references
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PROSITE | PS50162; RECA_2; 1; |
Pfam | PF05362; Lon_C; 1; |
PRINTS | PR01874; DNAREPAIRADA; 1; |
NCBIfam | TIGR00416; sms; 1; |
Features
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From: RADA_ECOLI (P24554) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ZN_FING | 11 | 28 | /note="C4-type" | C-x(2)-C-x(10)-C-x(2)-C | ||||||||
BINDING | 102 | 109 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
[GAS]-x-P-G-x-G-K-[ST] | ||||||||
REGION | 357 | Cter | /note="Lon-protease-like" | |||||||||
MOTIF | 258 | 262 | /note="RadA KNRFG motif" | K-N-R-[FY]-G |
Additional information
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Size range | 420-505 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |
Comments | A number of Streptococcus pneumoniae do not encode the possible zinc-finger. Not a homolog of the archaeal RadA protein. |