Due to maintenance work, this service will be unavailable from Mon Nov 11 17:30 until Tue Nov 12 09:00 CET. Apologies for the inconvenience.

HAMAP rule MF_01558

General rule information [?]

Accession	MF_01558
Dates	12-DEC-2005 (Created) 1-JUN-2023 (Last updated, Version 21)
Name	Cyt_deam
Scope(s)	Bacteria Gammaproteobacteria
Template(s)	P0ABF6 (CDD_ECOLI); [ Recover all ]
Triggered by	HAMAP; MF_01558 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	CDD
Protein name	RecName: Full=Cytidine deaminase; EC=3.5.4.5; AltName: Full=Cytidine aminohydrolase; Short=CDA;
Gene name	Name=cdd;

Comments [?]

FUNCTION	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
CATALYTIC ACTIVITY	Reaction=cytidine + H(+) + H2O = NH4(+) + uridine; Xref=Rhea:RHEA:16069, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16704, ChEBI:CHEBI:17562, ChEBI:CHEBI:28938; EC=3.5.4.5;
CATALYTIC ACTIVITY	Reaction=2'-deoxycytidine + H(+) + H2O = 2'-deoxyuridine + NH4(+); Xref=Rhea:RHEA:13433, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15698, ChEBI:CHEBI:16450, ChEBI:CHEBI:28938; EC=3.5.4.5;
case <FTGroup:1>
COFACTOR	Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion.;
end case
SUBUNIT	Homodimer.
SIMILARITY	Belongs to the cytidine and deoxycytidylate deaminase family.

Keywords [?]

Gene Ontology [?]

GO:0004126; Molecular function:cytidine deaminase activity
case <FTGroup:1>
GO:0008270; Molecular function:zinc ion binding
end case

Cross-references [?]

Features [?]

From: CDD_ECOLI (P0ABF6)

Key

From

Description

Tag

Condition

FTGroup

BINDING

/ligand="substrate"

N-x-E

ACT_SITE

104

/note="Proton donor"

BINDING

102

/ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_note="catalytic"

BINDING

129

/ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_note="catalytic"

BINDING

132

/ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_note="catalytic"

Additional information [?]