HAMAP rule MF_01558

General rule information [?]

Accession	MF_01558
Dates	12-DEC-2005 (Created) 1-JUN-2023 (Last updated, Version 21)

Name

Cyt_deam

Scope

Bacteria; Gammaproteobacteria

Template

P0ABF6 (CDD_ECOLI)

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

CDD

Protein name

RecName:		Full=Cytidine deaminase;
		EC 3.5.4.5;
AltName:		Full=Cytidine aminohydrolase;
		Short=CDA;

Gene name

cdd

Comments [?]

Function	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
Catalytic activity	RHEA:16069: cytidine + H(+) + H2O = NH4(+) + uridine EC 3.5.4.5
	RHEA:13433: 2'-deoxycytidine + H(+) + H2O = 2'-deoxyuridine + NH4(+) EC 3.5.4.5

case <FTGroup:1>

Cofactor

Zn(2+)
Note: Binds 1 zinc ion.

end case

Subunit	Homodimer.
Similarity	Belongs to the cytidine and deoxycytidylate deaminase family.

Keywords [?]

case <FTGroup:1>

end case

Gene Ontology [?]

GO:0004126; Molecular function: cytidine deaminase activity.

case <FTGroup:1>

GO:0008270; Molecular function: zinc ion binding.

end case

Cross-references [?]

Pfam	PF00383; dCMP_cyt_deam_1; 1;
	PF08211; dCMP_cyt_deam_2; 1;
NCBIfam	TIGR01355; Cyt_deam_dimer; 1;
PROSITE	PS00903; CYT_DCMP_DEAMINASES_1; 1;
	PS51747; CYT_DCMP_DEAMINASES_2; 2; trigger=PRU01083;

Features [?]

From: CDD_ECOLI (P0ABF6)

Key From To Description Tag Condition FTGroup

BINDING 89 91 /ligand="substrate N-x-E

ACT_SITE 104 104 Proton donor E

BINDING 102 102 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic H 1

BINDING 129 129 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic C 1

BINDING 132 132 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic C 1

Additional information [?]