HAMAP rule MF_01576

General rule information [?]

Accession	MF_01576
Dates	22-NOV-2006 (Created) 19-NOV-2022 (Last updated, Version 24)

Name	THF_DHG_CYH

Scope

Bacteria

Archaea

Templates

P24186 (FOLD_ECOLI); P51696 (FOLD_PHOPO); Q05213 (FOLD_THEAC); Q9I2U6 (FOLD_PSEAE); Q0PA35 (FOLD_CAMJE); Q5NGF3 (FOLD_FRATT); P9WG81 (FOLD_MYCTU): [Recover all]

Triggered by

HAMAP; MF_01576 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

FOLD

Protein name

RecName:		Full=Bifunctional protein FolD;
Includes:
	RecName:		Full=Methylenetetrahydrofolate dehydrogenase;
			EC 1.5.1.5;
Includes:
	RecName:		Full=Methenyltetrahydrofolate cyclohydrolase;
			EC 3.5.4.9;

Gene name

folD

Comments [?]

Function	Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
Catalytic activity	RHEA:22812: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH EC 1.5.1.5
	RHEA:23700: 5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+) EC 3.5.4.9
Pathway	One-carbon metabolism; tetrahydrofolate interconversion.
Subunit	Homodimer.
Similarity	Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Keywords [?]

Amino-acid biosynthesis
Histidine biosynthesis
Hydrolase
Methionine biosynthesis
Multifunctional enzyme
NADP
One-carbon metabolism
Oxidoreductase
Purine biosynthesis

Gene Ontology [?]

GO:0004477; Molecular function: methenyltetrahydrofolate cyclohydrolase activity.
GO:0004488; Molecular function: methylenetetrahydrofolate dehydrogenase (NADP+) activity.

Cross-references [?]

PROSITE	PS00766; THF_DHG_CYH_1; 1;
	PS00767; THF_DHG_CYH_2; 1;
Pfam	PF00763; THF_DHG_CYH; 1;
	PF02882; THF_DHG_CYH_C; 1;
PRINTS	PR00085; THFDHDRGNASE; 1;

Features [?]

From: FOLD_THEAC (Q05213)

Key From To Description Tag Condition FTGroup

BINDING 157 159 /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349 [GN]-x-[SG]

BINDING (Optional) 182 182 /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349 [ST]

BINDING (Optional) 182 182 /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349 I

BINDING (Optional) 223 223 /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349 [IVAT]

Additional information [?]

Size range	269-320 amino acids
Related rules	None
Fusion	None

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