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HAMAP rule MF_01576
General rule information
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| Accession | MF_01576 |
| Dates | 22-NOV-2006 (Created)
7-MAY-2024 (Last updated, Version 28) |
| Name | THF_DHG_CYH |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P24186 (FOLD_ECOLI); P51696 (FOLD_PHOPO); Q05213 (FOLD_THEAC); Q9I2U6 (FOLD_PSEAE); Q0PA35 (FOLD_CAMJE); Q5NGF3 (FOLD_FRATT); P9WG81 (FOLD_MYCTU); [ Recover all ] |
| Triggered by |
HAMAP; MF_01576 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | FOLD |
| Protein name | RecName: Full=Bifunctional protein FolD; Includes: RecName: Full=Methylenetetrahydrofolate dehydrogenase; EC=1.5.1.5; Includes: RecName: Full=Methenyltetrahydrofolate cyclohydrolase; EC=3.5.4.9; |
| Gene name | Name=folD; |
Comments
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| FUNCTION | Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. |
| CATALYTIC ACTIVITY | Reaction=(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)- 5,10-methenyltetrahydrofolate + NADPH; Xref=Rhea:RHEA:22812, ChEBI:CHEBI:15636, ChEBI:CHEBI:57455, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.5.1.5; |
| CATALYTIC ACTIVITY | Reaction=(6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10- formyltetrahydrofolate + H(+); Xref=Rhea:RHEA:23700, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57455, ChEBI:CHEBI:195366; EC=3.5.4.9; |
| PATHWAY | One-carbon metabolism; tetrahydrofolate interconversion. |
| SUBUNIT | Homodimer. |
| SIMILARITY | Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. |
Keywords
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| Amino-acid biosynthesis |
| Histidine biosynthesis |
| Hydrolase |
| Methionine biosynthesis |
| Multifunctional enzyme |
| NADP |
| One-carbon metabolism |
| Oxidoreductase |
| Purine biosynthesis |
Gene Ontology
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| GO:0004477; Molecular function:methenyltetrahydrofolate cyclohydrolase activity |
| GO:0004488; Molecular function:methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| GO:0035999; Biological process:tetrahydrofolate interconversion |
Cross-references
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| PROSITE | PS00766; THF_DHG_CYH_1; 1; |
| PROSITE | PS00767; THF_DHG_CYH_2; 1; |
| Pfam | PF00763; THF_DHG_CYH; 1; |
| Pfam | PF02882; THF_DHG_CYH_C; 1; |
| PRINTS | PR00085; THFDHDRGNASE; 1; |
Features
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| From: FOLD_THEAC (Q05213) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 157 | 159 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
[GN]-x-[SG] | ||||||||
| BINDING | 182 | 182 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
[ST] | ||||||||
| BINDING | 182 | 182 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
I | ||||||||
| BINDING | 223 | 223 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
[IVAT] | ||||||||
Additional information
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| Size range | 269-320 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |