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Annotation rule MF_01576
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General rule information [?]

Accession MF_01576
Dates 22-NOV-2006 (Created)
19-NOV-2019 (Last updated, Version 21)
Name THF_DHG_CYH
Scope
Bacteria
Archaea
Templates P24186 (FOLD_ECOLI); P51696 (FOLD_PHOPO); Q05213 (FOLD_THEAC); Q9I2U6 (FOLD_PSEAE); Q0PA35 (FOLD_CAMJE); Q5NGF3 (FOLD_FRATT); P9WG81 (FOLD_MYCTU): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
FOLD
Protein name
RecName: Full=Bifunctional protein FolD;
Includes:
RecName: Full=Methylenetetrahydrofolate dehydrogenase;
EC 1.5.1.5;
Includes:
RecName: Full=Methenyltetrahydrofolate cyclohydrolase;
EC 3.5.4.9;
Gene name
folD

Comments [?]

Function Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
Catalytic activity RHEA:22812: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH
EC 1.5.1.5
RHEA:23700: 5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)
EC 3.5.4.9
Pathway One-carbon metabolism; tetrahydrofolate interconversion.
Subunit Homodimer.
Similarity Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Keywords [?]


Gene Ontology [?]

GO:0004477; Molecular function: methenyltetrahydrofolate cyclohydrolase activity.
GO:0004488; Molecular function: methylenetetrahydrofolate dehydrogenase (NADP+) activity.

Cross-references [?]

PROSITE PS00766; THF_DHG_CYH_1; 1;
PS00767; THF_DHG_CYH_2; 1;
Pfam PF00763; THF_DHG_CYH; 1;
PF02882; THF_DHG_CYH_C; 1;
PRINTS PR00085; THFDHDRGNASE; 1;

Features [?]

From: FOLD_THEAC (Q05213)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     157     159       NADP     [GN]-x-[SG]  
BINDING (Optional)     182     182       NADP     [ST]  
BINDING (Optional)     182     182       NADP; via amide nitrogen     I  
BINDING (Optional)     223     223       NADP; via amide nitrogen     [IVAT]  

Additional information [?]

Size range 269-320 amino acids
Related rules None
Fusion None