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Annotation rule MF_01587 |
Accession | MF_01587 |
Dates | 15-NOV-2007 (Created) 19-NOV-2019 (Last updated, Version 13) |
Name | DNA_ligase_B |
Scope | Bacteria; Gammaproteobacteria |
Template | P25772 (LIGB_ECOLI) |
Triggered by |
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Protein name |
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Gene name |
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Function | Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. |
Catalytic activity | Reaction=NAD(+) + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + beta-nicotinamide D-nucleotide.; EC=6.5.1.2; |
Similarity | Belongs to the NAD-dependent DNA ligase family. LigB subfamily. |
PROSITE | PS01055; DNA_LIGASE_N1; 1; |
PS01056; DNA_LIGASE_N2; 1; | |
Pfam | PF01653; DNA_ligase_aden; 1; |
PF03120; DNA_ligase_OB; 1; |
From: LIGB_ECOLI (P25772) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 124 | 124 | N6-AMP-lysine intermediate | K |
Size range | 554-629 amino acids |
Related rules | MF_01588 (DNLJ) |
Fusion | None |