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Annotation rule MF_01587
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General rule information [?]

Accession MF_01587
Dates 15-NOV-2007 (Created)
19-NOV-2019 (Last updated, Version 13)
Name DNA_ligase_B
Scope
Bacteria; Gammaproteobacteria
Template P25772 (LIGB_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
LIGB
Protein name
RecName: Full=DNA ligase B;
EC 6.5.1.2;
AltName: Full=Polydeoxyribonucleotide synthase [NAD(+)] B;
Gene name
ligB

Comments [?]

Function Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.
Catalytic activity Reaction=NAD(+) + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + beta-nicotinamide D-nucleotide.; EC=6.5.1.2;
Similarity Belongs to the NAD-dependent DNA ligase family. LigB subfamily.

Keywords [?]

DNA damage
DNA repair
DNA replication
Ligase
NAD

Gene Ontology [?]

GO:0003911; Molecular function: DNA ligase (NAD+) activity.
GO:0006259; Biological process: DNA metabolic process.

Cross-references [?]

PROSITE PS01055; DNA_LIGASE_N1; 1;
PS01056; DNA_LIGASE_N2; 1;
Pfam PF01653; DNA_ligase_aden; 1;
PF03120; DNA_ligase_OB; 1;

Features [?]

From: LIGB_ECOLI (P25772)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     124     124       N6-AMP-lysine intermediate     K  

Additional information [?]

Size range 554-629 amino acids
Related rules MF_01588 (DNLJ)
Fusion None


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