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Annotation rule MF_01594 |
General rule information
[?]
Accession |
MF_01594 |
Dates |
1-FEB-2008 (Created) 19-NOV-2019 (Last updated, Version 18) |
Scope |
Bacteria; Enterobacterales |
Propagated annotation
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Identifier, protein and gene names
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Protein name |
RecName:
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Full=Rhomboid protease GlpG;
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EC 3.4.21.105;
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AltName:
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Full=Intramembrane serine protease;
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Function |
Rhomboid-type serine protease that catalyzes intramembrane proteolysis. |
Catalytic activity |
Reaction=Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.; EC=3.4.21.105; |
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location |
Cell membrane; Multi-pass membrane protein. |
else case <Property:Membrane=2>
Subcellular location |
Cell inner membrane; Multi-pass membrane protein. |
end case
Similarity |
Belongs to the peptidase S54 family. |
case defined <Property:Membrane> and <Property:Membrane=2>
end case
GO:0004252; Molecular function: serine-type endopeptidase activity.
GO:0006508; Biological process: proteolysis.
GO:0005886; Cellular component: plasma membrane.
General |
Transmembrane; -; 6; trigger=yes; |
From: GLPG_ECOLI (P09391) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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ACT_SITE
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201
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201
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Nucleophile
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S
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ACT_SITE
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254
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254
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H
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Additional information
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Size range |
260-300 amino acids |
Related rules |
None |
Fusion |
None |
Comments |
Active sites are not conserved in CROS8, suggesting that it has no peptidase activity. |