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Annotation rule MF_01594
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General rule information [?]

Accession MF_01594
Dates 1-FEB-2008 (Created)
19-NOV-2019 (Last updated, Version 18)
Name Rhomboid_GlpG
Scope
Bacteria; Enterobacterales
Template P09391 (GLPG_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
GLPG
Protein name
RecName: Full=Rhomboid protease GlpG;
EC 3.4.21.105;
AltName: Full=Intramembrane serine protease;
Gene name
glpG

Comments [?]

Function Rhomboid-type serine protease that catalyzes intramembrane proteolysis.
Catalytic activity Reaction=Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.; EC=3.4.21.105;
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Multi-pass membrane protein.
end case
Similarity Belongs to the peptidase S54 family.

Keywords [?]

Cell membrane
Hydrolase
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Membrane
Protease
Serine protease
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0004252; Molecular function: serine-type endopeptidase activity.
GO:0006508; Biological process: proteolysis.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF01694; Rhomboid; 1;
TIGRFAMs TIGR04239; rhombo_GlpG; 1;

Computed features [?]

General Transmembrane; -; 6; trigger=yes;

Features [?]

From: GLPG_ECOLI (P09391)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     201     201       Nucleophile     S  
ACT_SITE     254     254             H  

Additional information [?]

Size range 260-300 amino acids
Related rules None
Fusion None
Comments Active sites are not conserved in CROS8, suggesting that it has no peptidase activity.


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