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HAMAP rule MF_01594

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General rule information [?]

Accession MF_01594
Dates 1-FEB-2008 (Created)
1-JUN-2023 (Last updated, Version 19)
Name Rhomboid_GlpG
Scope(s) Bacteria
Template(s) P09391 (GLPG_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01594 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier GLPG
Protein name RecName: Full=Rhomboid protease GlpG;
AltName: Full=Intramembrane serine protease;
Gene name Name=glpG;

Comments [?]

FUNCTIONRhomboid-type serine protease that catalyzes intramembrane proteolysis.
CATALYTIC ACTIVITY Reaction=Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.; EC=;
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATIONCell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATIONCell inner membrane; Multi-pass membrane protein.
end case
SIMILARITYBelongs to the peptidase S54 family.

Keywords [?]

Cell membrane
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Serine protease
Transmembrane helix

Gene Ontology [?]

GO:0004252; Molecular function:serine-type endopeptidase activity
GO:0006508; Biological process:proteolysis
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF01694; Rhomboid; 1;
NCBIfam TIGR04239; rhombo_GlpG; 1;
General Transmembrane; -; 6;

Features [?]

From: GLPG_ECOLI (P09391)
Key From To Description Tag Condition FTGroup
ACT_SITE 201 201 /note="Nucleophile" S
ACT_SITE 254 254 H

Additional information [?]

Size range 260-300 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Active sites are not conserved in CROS8, suggesting that it has no peptidase activity.

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