HAMAP logo

HAMAP rule MF_01594

Send feedback

General rule information [?]

Accession MF_01594
Dates 1-FEB-2008 (Created)
1-JUN-2023 (Last updated, Version 19)
Name Rhomboid_GlpG
Scope
Bacteria; Enterobacterales
Template P09391 (GLPG_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
GLPG
Protein name
RecName: Full=Rhomboid protease GlpG;
EC 3.4.21.105;
AltName: Full=Intramembrane serine protease;
Gene name
glpG

Comments [?]

Function Rhomboid-type serine protease that catalyzes intramembrane proteolysis.
Catalytic activity Reaction=Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.; EC=3.4.21.105;
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Multi-pass membrane protein.
end case
Similarity Belongs to the peptidase S54 family.

Keywords [?]

Cell membrane
Hydrolase
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Membrane
Protease
Serine protease
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0004252; Molecular function: serine-type endopeptidase activity.
GO:0006508; Biological process: proteolysis.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF01694; Rhomboid; 1;
NCBIfam TIGR04239; rhombo_GlpG; 1;

Computed features [?]

General Transmembrane; -; 6; trigger=yes;

Features [?]

From: GLPG_ECOLI (P09391)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     201     201       Nucleophile     S  
ACT_SITE     254     254             H  

Additional information [?]

Size range 260-300 amino acids
Related rules None
Fusion None
Comments Active sites are not conserved in CROS8, suggesting that it has no peptidase activity.


View rule in raw text format (no links)