HAMAP rule MF_01594
General rule information
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Accession | MF_01594 |
Dates | 1-FEB-2008 (Created) 1-JUN-2023 (Last updated, Version 19) |
Name | Rhomboid_GlpG |
Scope | Bacteria; Enterobacterales |
Template | P09391 (GLPG_ECOLI) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Rhomboid-type serine protease that catalyzes intramembrane proteolysis. |
Catalytic activity | Reaction=Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.; EC=3.4.21.105; |
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location | Cell membrane; Multi-pass membrane protein. |
else case <Property:Membrane=2>
Subcellular location | Cell inner membrane; Multi-pass membrane protein. |
end case
Similarity | Belongs to the peptidase S54 family. |
Keywords
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case defined <Property:Membrane> and <Property:Membrane=2>
end case
Gene Ontology
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GO:0004252; Molecular function: serine-type endopeptidase activity.
GO:0006508; Biological process: proteolysis.
GO:0005886; Cellular component: plasma membrane.
GO:0006508; Biological process: proteolysis.
GO:0005886; Cellular component: plasma membrane.
Cross-references
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Computed features
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General | Transmembrane; -; 6; trigger=yes; |
Features
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From: GLPG_ECOLI (P09391) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 201 | 201 | Nucleophile | S | ||||||||
ACT_SITE | 254 | 254 | H |
Additional information
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Size range | 260-300 amino acids |
Related rules | None |
Fusion | None |
Comments | Active sites are not conserved in CROS8, suggesting that it has no peptidase activity. |