HAMAP rule MF_01619
General rule information
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Accession | MF_01619 |
Dates | 16-NOV-2005 (Created) 26-JAN-2023 (Last updated, Version 21) |
Name | NAD_malic_enz |
Scope | Bacteria; Pseudomonadota |
Template | P26616 (MAO1_ECOLI) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Catalytic activity | RHEA:12653: (S)-malate + NAD(+) = CO2 + NADH + pyruvate
EC 1.1.1.38 |
RHEA:15641: H(+) + oxaloacetate = CO2 + pyruvate
EC 1.1.1.38 |
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Cofactor | Mg(2+) Mn(2+) Note: Divalent metal cations. Prefers magnesium or manganese. |
Subunit | Homotetramer. |
Similarity | Belongs to the malic enzymes family. |
Keywords
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Gene Ontology
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GO:0004471; Molecular function: malate dehydrogenase (decarboxylating) (NAD+) activity.
GO:0008948; Molecular function: oxaloacetate decarboxylase activity.
GO:0008948; Molecular function: oxaloacetate decarboxylase activity.
Cross-references
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PROSITE | PS00331; MALIC_ENZYMES; 1; |
Pfam | PF00390; malic; 1; |
PF03949; Malic_M; 1; | |
PRINTS | PR00072; MALOXRDTASE; 1; |
Features
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From: MAO1_ECOLI (P26616) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 104 | 104 | Proton donor | Y | ||||||||
ACT_SITE | 175 | 175 | Proton acceptor | K | ||||||||
BINDING | 246 | 246 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240 | E | ||||||||
BINDING | 247 | 247 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240 | D | ||||||||
BINDING | 270 | 270 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240 | D | ||||||||
BINDING | 157 | 157 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | R | ||||||||
BINDING | 270 | 270 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | D | ||||||||
BINDING | 418 | 418 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | N | ||||||||
SITE | 270 | 270 | Important for activity |
Additional information
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Size range | 528-591 amino acids |
Related rules | None |
Fusion | None |