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Annotation rule MF_01619
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General rule information [?]

Accession MF_01619
Dates 16-NOV-2005 (Created)
19-NOV-2019 (Last updated, Version 18)
Name NAD_malic_enz
Scope
Bacteria; Proteobacteria
Template P26616 (MAO1_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MAO1
Protein name
RecName: Full=NAD-dependent malic enzyme;
Short=NAD-ME;
EC 1.1.1.38;
Gene name
maeA

Comments [?]

Catalytic activity RHEA:12653: (S)-malate + NAD(+) = CO2 + NADH + pyruvate
EC 1.1.1.38
RHEA:15641: H(+) + oxaloacetate = CO2 + pyruvate
EC 1.1.1.38
Cofactor Mg(2+)
Mn(2+)
Note: Divalent metal cations. Prefers magnesium or manganese.
Subunit Homotetramer.
Similarity Belongs to the malic enzymes family.

Keywords [?]


Gene Ontology [?]

GO:0004471; Molecular function: malate dehydrogenase (decarboxylating) (NAD+) activity.
GO:0008948; Molecular function: oxaloacetate decarboxylase activity.

Cross-references [?]

PROSITE PS00331; MALIC_ENZYMES; 1;
Pfam PF00390; malic; 1;
PF03949; Malic_M; 1;
PRINTS PR00072; MALOXRDTASE; 1;

Features [?]

From: MAO1_ECOLI (P26616)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     104     104       Proton donor     Y  
ACT_SITE     175     175       Proton acceptor     K  
METAL     246     246       Divalent metal cation     E  
METAL     247     247       Divalent metal cation     D  
METAL     270     270       Divalent metal cation     D  
BINDING     157     157       NAD     R  
BINDING     270     270       NAD     D  
BINDING     418     418       NAD     N  
SITE     270     270       Important for activity        

Additional information [?]

Size range 528-591 amino acids
Related rules None
Fusion None