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HAMAP rule MF_01635

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General rule information [?]

Accession MF_01635
Dates 14-NOV-2006 (Created)
1-JUN-2023 (Last updated, Version 25)
Name UbiA
Scope
Bacteria; Cyanobacteriota
Bacteria; Pseudomonadota
Templates P0AGK1 (UBIA_ECOLI); Q55500 (PLQA_SYNY3): [Recover all]
case <OC:Bacteria>
Triggered by
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

case <OC:Pseudomonadota>
Identifier
UBIA
Protein name
RecName: Full=4-hydroxybenzoate octaprenyltransferase;
EC 2.5.1.39;
AltName: Full=4-HB polyprenyltransferase;
Gene name
ubiA
else case <OC:Cyanobacteriota>
Identifier
PLQA
Protein name
RecName: Full=4-hydroxybenzoate solanesyltransferase;
EC 2.5.1.39;
AltName: Full=4-HB polyprenyltransferase;
Gene name
plqA
end case

Comments [?]

case <OC:Pseudomonadota>
Function Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
Catalytic activity RHEA:27782: 4-hydroxybenzoate + all-trans-octaprenyl diphosphate = 4-hydroxy-3-all-trans-octaprenylbenzoate + diphosphate
EC 2.5.1.39
Pathway Cofactor biosynthesis; ubiquinone biosynthesis.
else case <OC:Cyanobacteriota>
Function Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of plastoquinone-9 (PQ-9) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 4-hydroxy-3-solanesylbenzoate.
Catalytic activity RHEA:17709: 4-hydroxybenzoate + all-trans-nonaprenyl diphosphate = 4-hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate
EC 2.5.1.39
end case
Cofactor Mg(2+)
Subcellular location Cell inner membrane; Multi-pass membrane protein.
Similarity Belongs to the UbiA prenyltransferase family.

Keywords [?]

Cell membrane
Cell inner membrane
Magnesium
Membrane
Transferase
Transmembrane
Transmembrane helix
case <OC:Pseudomonadota>
Ubiquinone biosynthesis
end case

Gene Ontology [?]

case <OC:Pseudomonadota>
GO:0008412; Molecular function: 4-hydroxybenzoate octaprenyltransferase activity.
GO:0006744; Biological process: ubiquinone biosynthetic process.
else case <OC:Cyanobacteriota>
GO:0004659; Molecular function: prenyltransferase activity.
GO:0010236; Biological process: plastoquinone biosynthetic process.
end case
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

PROSITE PS00943; UBIA; 1;
Pfam PF01040; UbiA; 1;
PRINTS PR01415; ANKYRIN; 1;
NCBIfam TIGR01474; UbiA_proteo; 1;

Computed features [?]

General Transmembrane; -; 5-9; trigger=yes;

Additional information [?]

Size range 240-390 amino acids
Related rules None
Fusion None


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