HAMAP rule MF_01635
General rule information
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Accession | MF_01635 |
Dates | 14-NOV-2006 (Created) 1-JUN-2023 (Last updated, Version 25) |
Name | UbiA |
Scope | Bacteria; Cyanobacteriota
Bacteria; Pseudomonadota |
Templates | P0AGK1 (UBIA_ECOLI); Q55500 (PLQA_SYNY3): [Recover all] |
case <OC:Bacteria>
Triggered by |
end case
Propagated annotation
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Identifier, protein and gene names
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case <OC:Pseudomonadota>
Identifier |
|
Protein name |
|
Gene name |
|
else case <OC:Cyanobacteriota>
Identifier |
|
Protein name |
|
Gene name |
|
end case
Comments
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case <OC:Pseudomonadota>
Function | Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. |
Catalytic activity | RHEA:27782: 4-hydroxybenzoate + all-trans-octaprenyl diphosphate = 4-hydroxy-3-all-trans-octaprenylbenzoate + diphosphate
EC 2.5.1.39 |
Pathway | Cofactor biosynthesis; ubiquinone biosynthesis. |
else case <OC:Cyanobacteriota>
Function | Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of plastoquinone-9 (PQ-9) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 4-hydroxy-3-solanesylbenzoate. |
Catalytic activity | RHEA:17709: 4-hydroxybenzoate + all-trans-nonaprenyl diphosphate = 4-hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate
EC 2.5.1.39 |
end case
Cofactor | Mg(2+) |
Subcellular location | Cell inner membrane; Multi-pass membrane protein. |
Similarity | Belongs to the UbiA prenyltransferase family. |
Keywords
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case <OC:Pseudomonadota>
end case
Gene Ontology
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case <OC:Pseudomonadota>
GO:0008412; Molecular function: 4-hydroxybenzoate octaprenyltransferase activity.
GO:0006744; Biological process: ubiquinone biosynthetic process.
GO:0006744; Biological process: ubiquinone biosynthetic process.
else case <OC:Cyanobacteriota>
GO:0004659; Molecular function: prenyltransferase activity.
GO:0010236; Biological process: plastoquinone biosynthetic process.
GO:0010236; Biological process: plastoquinone biosynthetic process.
end case
GO:0005886; Cellular component: plasma membrane.
Cross-references
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PROSITE | PS00943; UBIA; 1; |
Pfam | PF01040; UbiA; 1; |
PRINTS | PR01415; ANKYRIN; 1; |
NCBIfam | TIGR01474; UbiA_proteo; 1; |
Computed features
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General | Transmembrane; -; 5-9; trigger=yes; |
Additional information
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Size range | 240-390 amino acids |
Related rules | None |
Fusion | None |