HAMAP rule MF_01635
General rule information
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| Accession | MF_01635 |
| Dates | 14-NOV-2006 (Created)
1-JUN-2023 (Last updated, Version 25) |
| Name | UbiA |
| Scope(s) |
Bacteria Cyanobacteriota Pseudomonadota |
| Template(s) | P0AGK1 (UBIA_ECOLI); Q55500 (PLQA_SYNY3); [ Recover all ] |
| Triggered by |
case c? <OC:Bacteria>
HAMAP; MF_01635 (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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| case <OC:Pseudomonadota> | |
| Identifier | UBIA |
| Protein name | RecName: Full=4-hydroxybenzoate octaprenyltransferase; EC=2.5.1.39; AltName: Full=4-HB polyprenyltransferase; |
| Gene name | Name=ubiA; |
| else case <OC:Cyanobacteriota> | |
| Identifier | PLQA |
| Protein name | RecName: Full=4-hydroxybenzoate solanesyltransferase; EC=2.5.1.39; AltName: Full=4-HB polyprenyltransferase; |
| Gene name | Name=plqA; |
| end case | |
Comments
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| case <OC:Pseudomonadota> | |
| FUNCTION | Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. |
| CATALYTIC ACTIVITY | Reaction=4-hydroxybenzoate + all-trans-octaprenyl diphosphate = 4- hydroxy-3-all-trans-octaprenylbenzoate + diphosphate; Xref=Rhea:RHEA:27782, ChEBI:CHEBI:1617, ChEBI:CHEBI:17879, ChEBI:CHEBI:33019, ChEBI:CHEBI:57711; EC=2.5.1.39; |
| PATHWAY | Cofactor biosynthesis; ubiquinone biosynthesis. |
| else case <OC:Cyanobacteriota> | |
| FUNCTION | Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of plastoquinone-9 (PQ-9) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 4-hydroxy-3-solanesylbenzoate. |
| CATALYTIC ACTIVITY | Reaction=4-hydroxybenzoate + all-trans-nonaprenyl diphosphate = 4- hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate; Xref=Rhea:RHEA:17709, ChEBI:CHEBI:17879, ChEBI:CHEBI:33019, ChEBI:CHEBI:58391, ChEBI:CHEBI:84502; EC=2.5.1.39; |
| end case | |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
| SUBCELLULAR LOCATION | Cell inner membrane; Multi-pass membrane protein. |
| SIMILARITY | Belongs to the UbiA prenyltransferase family. |
Keywords
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| Cell membrane | |
| Cell inner membrane | |
| Magnesium | |
| Membrane | |
| Transferase | |
| Transmembrane | |
| Transmembrane helix | |
| case <OC:Pseudomonadota> | |
| Ubiquinone biosynthesis | |
| end case | |
Gene Ontology
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| case <OCellular component:Pseudomonadota> | |
| GO:0008412; Molecular function:4-hydroxybenzoate octaprenyltransferase activity | |
| GO:0006744; Biological process:ubiquinone biosynthetic process | |
| else case <OCellular component:Cyanobacteriota> | |
| GO:0004659; Molecular function:prenyltransferase activity | |
| GO:0010236; Biological process:plastoquinone biosynthetic process | |
| end case | |
| GO:0005886; Cellular component:plasma membrane | |
Cross-references
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| PROSITE | PS00943; UBIA; 1; |
| Pfam | PF01040; UbiA; 1; |
| PRINTS | PR01415; ANKYRIN; 1; |
| NCBIfam | TIGR01474; UbiA_proteo; 1; |
| General | Transmembrane; -; 5-9; |
Features
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Additional information
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| Size range | 240-390 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |