HAMAP rule MF_01640
General rule information
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| Accession | MF_01640 |
| Dates | 11-JUN-2007 (Created)
1-JUN-2023 (Last updated, Version 24) |
| Name | E4P_dehydrog |
| Scope(s) |
Bacteria Pseudomonadota |
| Template(s) | P0A9B6 (E4PD_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01640 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | E4PD |
| Protein name | RecName: Full=D-erythrose-4-phosphate dehydrogenase; Short=E4PDH; EC=1.2.1.72; |
| Gene name | Name=epd; |
Comments
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| FUNCTION | Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate. |
| CATALYTIC ACTIVITY | Reaction=D-erythrose 4-phosphate + H2O + NAD(+) = 4-phospho-D- erythronate + 2 H(+) + NADH; Xref=Rhea:RHEA:12056, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16897, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:58766; EC=1.2.1.72; |
| PATHWAY | Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 1/5. |
| SUBUNIT | Homotetramer. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily. |
Keywords
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Gene Ontology
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| GO:0048001; Molecular function:erythrose-4-phosphate dehydrogenase activity |
| GO:0042823; Biological process:pyridoxal phosphate biosynthetic process |
| GO:0008615; Biological process:pyridoxine biosynthetic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| PROSITE | PS00071; GAPDH; 1; |
| Pfam | PF02800; Gp_dh_C; 1; |
| Pfam | PF00044; Gp_dh_N; 1; |
| PRINTS | PR00078; G3PDHDRGNASE; 1; |
| NCBIfam | TIGR01532; E4PD_g-proteo; 1; |
Features
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| From: E4PD_ECOLI (P0A9B6) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 12 | 13 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
R-[IV] | ||||||||
| BINDING | 154 | 156 | /ligand="substrate" | S-C-T | ||||||||
| BINDING | 213 | 214 | /ligand="substrate" | T-[KR] | ||||||||
| ACT_SITE | 155 | 155 | /note="Nucleophile" | C | ||||||||
| BINDING | 81 | 81 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
R | ||||||||
| BINDING | 200 | 200 | /ligand="substrate" | R | ||||||||
| BINDING | 236 | 236 | /ligand="substrate" | R | ||||||||
| BINDING | 318 | 318 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
N | ||||||||
| SITE | 182 | 182 | /note="Activates thiol group during catalysis" | H | ||||||||
Additional information
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| Size range | 336-371 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |