HAMAP rule MF_01640
General rule information
[?]
| Accession | MF_01640 |
| Dates | 11-JUN-2007 (Created) 1-JUN-2023 (Last updated, Version 24) |
| Name | E4P_dehydrog |
| Scope | Bacteria; Pseudomonadota |
| Template | P0A9B6 (E4PD_ECOLI) |
| Triggered by |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier |
|
| Protein name |
|
||||||||||||
| Gene name |
|
Comments
[?]
| Function | Catalyzes the NAD-dependent conversion of D-erythrose 4-phosphate to 4-phosphoerythronate. |
| Catalytic activity | RHEA:12056: D-erythrose 4-phosphate + H2O + NAD(+) = 4-phospho-D-erythronate + 2 H(+) + NADH
EC 1.2.1.72 |
| Pathway | Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 1/5. |
| Subunit | Homotetramer. |
| Subcellular location | Cytoplasm. |
| Similarity | Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily. |
Keywords
[?]
Gene Ontology
[?]
GO:0048001; Molecular function: erythrose-4-phosphate dehydrogenase activity.
GO:0042823; Biological process: pyridoxal phosphate biosynthetic process.
GO:0008615; Biological process: pyridoxine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
GO:0042823; Biological process: pyridoxal phosphate biosynthetic process.
GO:0008615; Biological process: pyridoxine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
Cross-references
[?]
| PROSITE | PS00071; GAPDH; 1; |
| Pfam | PF02800; Gp_dh_C; 1; |
| PF00044; Gp_dh_N; 1; | |
| PRINTS | PR00078; G3PDHDRGNASE; 1; |
| NCBIfam | TIGR01532; E4PD_g-proteo; 1; |
Features
[?]
| From: E4PD_ECOLI (P0A9B6) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 12 | 13 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | R-[IV] | ||||||||
| BINDING | 154 | 156 | /ligand="substrate | S-C-T | ||||||||
| BINDING | 213 | 214 | /ligand="substrate | T-[KR] | ||||||||
| ACT_SITE | 155 | 155 | Nucleophile | C | ||||||||
| BINDING (Optional) | 81 | 81 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | R | ||||||||
| BINDING (Optional) | 200 | 200 | /ligand="substrate | R | ||||||||
| BINDING (Optional) | 236 | 236 | /ligand="substrate | R | ||||||||
| BINDING (Optional) | 318 | 318 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | N | ||||||||
| SITE | 182 | 182 | Activates thiol group during catalysis | H | ||||||||
Additional information
[?]
| Size range | 336-371 amino acids |
| Related rules | None |
| Fusion | None |