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HAMAP rule MF_01647

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General rule information [?]

Accession MF_01647
Dates 17-APR-2008 (Created)
19-NOV-2022 (Last updated, Version 20)
Name HcaB
Scope(s) Bacteria
Enterobacterales
Template(s) P0CI31 (HCAB_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01647 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier HCAB
Protein name RecName: Full=3-phenylpropionate-dihydrodiol/cinnamic acid-dihydrodiol dehydrogenase;
                 EC=1.3.1.87;
AltName: Full=2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase;
AltName: Full=3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase;
AltName: Full=CI-dihydrodiol dehydrogenase;
AltName: Full=Cis-3-(2-carboxyethenyl)-3,5-cyclohexadiene-1,2-diol dehydrogenase;
AltName: Full=Cis-3-(2-carboxyethyl)-3,5-cyclohexadiene-1,2-diol dehydrogenase;
AltName: Full=PP-dihydrodiol dehydrogenase;
Gene name Name=hcaB;

Comments [?]

FUNCTIONConverts 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol) into 3-(2,3- dihydroxylphenyl)propanoic acid (DHPP) and 2,3-dihydroxicinnamic acid (DHCI), respectively.
CATALYTIC ACTIVITY Reaction=3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+) = 3-(2,3-dihydroxyphenyl)propanoate + H(+) + NADH; Xref=Rhea:RHEA:25062, ChEBI:CHEBI:15378, ChEBI:CHEBI:46951, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:60087; EC=1.3.1.87;
CATALYTIC ACTIVITY Reaction=(2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+) = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H(+) + NADH; Xref=Rhea:RHEA:25066, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:58642, ChEBI:CHEBI:61451; EC=1.3.1.87;
PATHWAYAromatic compound metabolism; 3-phenylpropanoate degradation.
SIMILARITYBelongs to the short-chain dehydrogenases/reductases (SDR) family.

Keywords [?]


Gene Ontology [?]

GO:0016491; Molecular function:oxidoreductase activity
GO:0018498; Molecular function:2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase activity
GO:0019439; Biological process:aromatic compound catabolic process

Cross-references [?]

PROSITE PS00061; ADH_SHORT; 1;
Pfam PF00106; adh_short; 1;
PRINTS PR00081; GDHRDH; 1;
PRINTS PR00080; SDRFAMILY; 1;

Features [?]

From: HCAB_ECOLI (P0CI31)
Key From To Description Tag Condition FTGroup
BINDING 10 34 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"
ACT_SITE 156 156 /note="Proton acceptor" Y
BINDING 143 143 /ligand="substrate" S

Additional information [?]

Size range 270-280 amino acids
Related rules None
Fusion Nter: None Cter: None



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