Home  |  Contact
Annotation rule MF_01647
Send feedback

General rule information [?]

Accession MF_01647
Dates 17-APR-2008 (Created)
19-NOV-2019 (Last updated, Version 18)
Name HcaB
Scope
Bacteria; Enterobacterales
Template P0CI31 (HCAB_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
HCAB
Protein name
RecName: Full=3-phenylpropionate-dihydrodiol/cinnamic acid-dihydrodiol dehydrogenase;
EC 1.3.1.87;
AltName: Full=2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase;
AltName: Full=3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase;
AltName: Full=CI-dihydrodiol dehydrogenase;
AltName: Full=Cis-3-(2-carboxyethenyl)-3,5-cyclohexadiene-1,2-diol dehydrogenase;
AltName: Full=Cis-3-(2-carboxyethyl)-3,5-cyclohexadiene-1,2-diol dehydrogenase;
AltName: Full=PP-dihydrodiol dehydrogenase;
Gene name
hcaB

Comments [?]

Function Converts 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol) into 3-(2,3-dihydroxylphenyl)propanoic acid (DHPP) and 2,3-dihydroxicinnamic acid (DHCI), respectively.
Catalytic activity RHEA:25062: 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+) = 3-(2,3-dihydroxyphenyl)propanoate + H(+) + NADH
EC 1.3.1.87
RHEA:25066: (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+) = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H(+) + NADH
EC 1.3.1.87
Pathway Aromatic compound metabolism; 3-phenylpropanoate degradation.
Similarity Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Keywords [?]


Gene Ontology [?]

GO:0016491; Molecular function: oxidoreductase activity.
GO:0018498; Molecular function: 2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase activity.
GO:0019439; Biological process: aromatic compound catabolic process.

Cross-references [?]

PROSITE PS00061; ADH_SHORT; 1;
Pfam PF00106; adh_short; 1;
PRINTS PR00081; GDHRDH; 1;
PR00080; SDRFAMILY; 1;

Features [?]

From: HCAB_ECOLI (P0CI31)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     10     34       NAD        
ACT_SITE     156     156       Proton acceptor     Y  
BINDING     143     143       Substrate     S  

Additional information [?]

Size range 270-280 amino acids
Related rules None
Fusion None