HAMAP rule MF_01647
General rule information
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| Accession | MF_01647 |
| Dates | 17-APR-2008 (Created)
19-NOV-2022 (Last updated, Version 20) |
| Name | HcaB |
| Scope(s) |
Bacteria Enterobacterales |
| Template(s) | P0CI31 (HCAB_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01647 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | HCAB |
| Protein name | RecName: Full=3-phenylpropionate-dihydrodiol/cinnamic acid-dihydrodiol dehydrogenase; EC=1.3.1.87; AltName: Full=2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; AltName: Full=3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase; AltName: Full=CI-dihydrodiol dehydrogenase; AltName: Full=Cis-3-(2-carboxyethenyl)-3,5-cyclohexadiene-1,2-diol dehydrogenase; AltName: Full=Cis-3-(2-carboxyethyl)-3,5-cyclohexadiene-1,2-diol dehydrogenase; AltName: Full=PP-dihydrodiol dehydrogenase; |
| Gene name | Name=hcaB; |
Comments
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| FUNCTION | Converts 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol) into 3-(2,3- dihydroxylphenyl)propanoic acid (DHPP) and 2,3-dihydroxicinnamic acid (DHCI), respectively. |
| CATALYTIC ACTIVITY | Reaction=3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+) = 3-(2,3-dihydroxyphenyl)propanoate + H(+) + NADH; Xref=Rhea:RHEA:25062, ChEBI:CHEBI:15378, ChEBI:CHEBI:46951, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:60087; EC=1.3.1.87; |
| CATALYTIC ACTIVITY | Reaction=(2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+) = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H(+) + NADH; Xref=Rhea:RHEA:25066, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:58642, ChEBI:CHEBI:61451; EC=1.3.1.87; |
| PATHWAY | Aromatic compound metabolism; 3-phenylpropanoate degradation. |
| SIMILARITY | Belongs to the short-chain dehydrogenases/reductases (SDR) family. |
Keywords
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Gene Ontology
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| GO:0016491; Molecular function:oxidoreductase activity |
| GO:0018498; Molecular function:2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase activity |
| GO:0019439; Biological process:aromatic compound catabolic process |
Cross-references
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| PROSITE | PS00061; ADH_SHORT; 1; |
| Pfam | PF00106; adh_short; 1; |
| PRINTS | PR00081; GDHRDH; 1; |
| PRINTS | PR00080; SDRFAMILY; 1; |
Features
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| From: HCAB_ECOLI (P0CI31) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 10 | 34 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
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| ACT_SITE | 156 | 156 | /note="Proton acceptor" | Y | ||||||||
| BINDING | 143 | 143 | /ligand="substrate" | S | ||||||||
Additional information
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| Size range | 270-280 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |