HAMAP rule MF_01647
General rule information
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Accession | MF_01647 |
Dates | 17-APR-2008 (Created) 19-NOV-2022 (Last updated, Version 20) |
Name | HcaB |
Scope | Bacteria; Enterobacterales |
Template | P0CI31 (HCAB_ECOLI) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Converts 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol) into 3-(2,3-dihydroxylphenyl)propanoic acid (DHPP) and 2,3-dihydroxicinnamic acid (DHCI), respectively. |
Catalytic activity | RHEA:25062: 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+) = 3-(2,3-dihydroxyphenyl)propanoate + H(+) + NADH
EC 1.3.1.87 |
RHEA:25066: (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+) = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H(+) + NADH
EC 1.3.1.87 |
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Pathway | Aromatic compound metabolism; 3-phenylpropanoate degradation. |
Similarity | Belongs to the short-chain dehydrogenases/reductases (SDR) family. |
Keywords
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Gene Ontology
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GO:0016491; Molecular function: oxidoreductase activity.
GO:0018498; Molecular function: 2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase activity.
GO:0019439; Biological process: aromatic compound catabolic process.
GO:0018498; Molecular function: 2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase activity.
GO:0019439; Biological process: aromatic compound catabolic process.
Cross-references
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PROSITE | PS00061; ADH_SHORT; 1; |
Pfam | PF00106; adh_short; 1; |
PRINTS | PR00081; GDHRDH; 1; |
PR00080; SDRFAMILY; 1; |
Features
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From: HCAB_ECOLI (P0CI31) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 10 | 34 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | |||||||||
ACT_SITE | 156 | 156 | Proton acceptor | Y | ||||||||
BINDING | 143 | 143 | /ligand="substrate | S |
Additional information
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Size range | 270-280 amino acids |
Related rules | None |
Fusion | None |