HAMAP rule MF_01647

General rule information [?]

Accession	MF_01647
Dates	17-APR-2008 (Created) 19-NOV-2022 (Last updated, Version 20)

Name

HcaB

Scope

Bacteria; Enterobacterales

Template

P0CI31 (HCAB_ECOLI)

Triggered by

HAMAP; MF_01647 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

HCAB

Protein name

RecName:		Full=3-phenylpropionate-dihydrodiol/cinnamic acid-dihydrodiol dehydrogenase;
		EC 1.3.1.87;
AltName:		Full=2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase;
AltName:		Full=3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase;
AltName:		Full=CI-dihydrodiol dehydrogenase;
AltName:		Full=Cis-3-(2-carboxyethenyl)-3,5-cyclohexadiene-1,2-diol dehydrogenase;
AltName:		Full=Cis-3-(2-carboxyethyl)-3,5-cyclohexadiene-1,2-diol dehydrogenase;
AltName:		Full=PP-dihydrodiol dehydrogenase;

Gene name

hcaB

Comments [?]

Function	Converts 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol) into 3-(2,3-dihydroxylphenyl)propanoic acid (DHPP) and 2,3-dihydroxicinnamic acid (DHCI), respectively.
Catalytic activity	RHEA:25062: 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+) = 3-(2,3-dihydroxyphenyl)propanoate + H(+) + NADH EC 1.3.1.87
	RHEA:25066: (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+) = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H(+) + NADH EC 1.3.1.87
Pathway	Aromatic compound metabolism; 3-phenylpropanoate degradation.
Similarity	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Keywords [?]

Aromatic hydrocarbons catabolism
NAD
Oxidoreductase

Gene Ontology [?]

GO:0016491; Molecular function: oxidoreductase activity.
GO:0018498; Molecular function: 2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase activity.
GO:0019439; Biological process: aromatic compound catabolic process.

Cross-references [?]

PROSITE	PS00061; ADH_SHORT; 1;
Pfam	PF00106; adh_short; 1;
PRINTS	PR00081; GDHRDH; 1;
	PR00080; SDRFAMILY; 1;

Features [?]

From: HCAB_ECOLI (P0CI31)

Key From To Description Tag Condition FTGroup

BINDING 10 34 /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540

ACT_SITE 156 156 Proton acceptor Y

BINDING 143 143 /ligand="substrate S

Additional information [?]

Size range	270-280 amino acids
Related rules	None
Fusion	None

View rule in raw text format (no links)