HAMAP rule MF_01652

General rule information [?]

Accession	MF_01652
Dates	29-APR-2008 (Created) 17-FEB-2023 (Last updated, Version 25)

Name

MhpA

Scope

Bacteria; Mycobacteriales

Bacteria; Pseudomonadota

Template

P77397 (MHPA_ECOLI)

Triggered by

HAMAP; MF_01652 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

MHPA

Protein name

RecName:		Full=3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase;
		Short=3-HCI hydroxylase;
		Short=3-HPP hydroxylase;
		EC 1.14.13.127;

Gene name

mhpA

Comments [?]

Function	Catalyzes the insertion of one atom of molecular oxygen into position 2 of the phenyl ring of 3-(3-hydroxyphenyl)propionate (3-HPP) and hydroxycinnamic acid (3HCI).
Catalytic activity	RHEA:24785: 3-(3-hydroxyphenyl)propanoate + H(+) + NADH + O2 = 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+) EC 1.14.13.127
	RHEA:27846: (2E)-3-(3-hydroxyphenyl)prop-2-enoate + H(+) + NADH + O2 = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H2O + NAD(+) EC 1.14.13.127
Cofactor	FAD
Pathway	Aromatic compound metabolism; 3-phenylpropanoate degradation.
Similarity	Belongs to the PheA/TfdB FAD monooxygenase family.

Keywords [?]

Aromatic hydrocarbons catabolism
FAD
Flavoprotein
NAD
Oxidoreductase

Gene Ontology [?]

GO:0008688; Molecular function: 3-(3-hydroxyphenyl)propionate hydroxylase activity.
GO:0019622; Biological process: 3-(3-hydroxy)phenylpropionate catabolic process.

Cross-references [?]

Pfam	PF01494; FAD_binding_3; 1;
PRINTS	PR00420; RNGMNOXGNASE; 1;
	PR00368; FADPNR; 1;

Features [?]

From: MHPA_ECOLI (P77397)

Key From To Description Tag Condition FTGroup

BINDING 17 46 /ligand="FAD" /ligand_id="ChEBI:CHEBI:57692

BINDING 285 295 /ligand="FAD" /ligand_id="ChEBI:CHEBI:57692

Additional information [?]

Size range	439-622 amino acids
Related rules	None
Fusion	None

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