HAMAP rule MF_01652
General rule information
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Accession | MF_01652 |
Dates | 29-APR-2008 (Created) 17-FEB-2023 (Last updated, Version 25) |
Name | MhpA |
Scope | Bacteria; Mycobacteriales
Bacteria; Pseudomonadota |
Template | P77397 (MHPA_ECOLI) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the insertion of one atom of molecular oxygen into position 2 of the phenyl ring of 3-(3-hydroxyphenyl)propionate (3-HPP) and hydroxycinnamic acid (3HCI). |
Catalytic activity | RHEA:24785: 3-(3-hydroxyphenyl)propanoate + H(+) + NADH + O2 = 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+)
EC 1.14.13.127 |
RHEA:27846: (2E)-3-(3-hydroxyphenyl)prop-2-enoate + H(+) + NADH + O2 = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H2O + NAD(+)
EC 1.14.13.127 |
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Cofactor | FAD |
Pathway | Aromatic compound metabolism; 3-phenylpropanoate degradation. |
Similarity | Belongs to the PheA/TfdB FAD monooxygenase family. |
Keywords
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Gene Ontology
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GO:0008688; Molecular function: 3-(3-hydroxyphenyl)propionate hydroxylase activity.
GO:0019622; Biological process: 3-(3-hydroxy)phenylpropionate catabolic process.
GO:0019622; Biological process: 3-(3-hydroxy)phenylpropionate catabolic process.
Cross-references
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Features
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From: MHPA_ECOLI (P77397) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 17 | 46 | /ligand="FAD" /ligand_id="ChEBI:CHEBI:57692 | |||||||||
BINDING | 285 | 295 | /ligand="FAD" /ligand_id="ChEBI:CHEBI:57692 |
Additional information
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Size range | 439-622 amino acids |
Related rules | None |
Fusion | None |