HAMAP rule MF_01666
General rule information
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| Accession | MF_01666 |
| Dates | 5-AUG-2008 (Created)
7-OCT-2022 (Last updated, Version 12) |
| Name | 2_Hacid_dh_C_GhrA |
| Scope(s) |
Bacteria Enterobacterales |
| Template(s) | P75913 (GHRA_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01666 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | GHRA |
| Protein name | RecName: Full=Glyoxylate/hydroxypyruvate reductase A; EC=1.1.1.81; EC=1.1.1.79; AltName: Full=2-ketoacid reductase; |
| Gene name | Name=ghrA; |
Comments
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| FUNCTION | Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. |
| CATALYTIC ACTIVITY | Reaction=glycolate + NADP(+) = glyoxylate + H(+) + NADPH; Xref=Rhea:RHEA:10992, ChEBI:CHEBI:15378, ChEBI:CHEBI:29805, ChEBI:CHEBI:36655, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.79; |
| CATALYTIC ACTIVITY | Reaction=(R)-glycerate + NAD(+) = 3-hydroxypyruvate + H(+) + NADH; Xref=Rhea:RHEA:17905, ChEBI:CHEBI:15378, ChEBI:CHEBI:16659, ChEBI:CHEBI:17180, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.81; |
| CATALYTIC ACTIVITY | Reaction=(R)-glycerate + NADP(+) = 3-hydroxypyruvate + H(+) + NADPH; Xref=Rhea:RHEA:18657, ChEBI:CHEBI:15378, ChEBI:CHEBI:16659, ChEBI:CHEBI:17180, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.81; |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily. |
Keywords
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Gene Ontology
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| GO:0016618; Molecular function:hydroxypyruvate reductase activity |
| GO:0030267; Molecular function:glyoxylate reductase (NADP+) activity |
Cross-references
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| PROSITE | PS00065; D_2_HYDROXYACID_DH_1; 1; |
| PROSITE | PS00670; D_2_HYDROXYACID_DH_2; 1; |
| PROSITE | PS00671; D_2_HYDROXYACID_DH_3; 1; |
| Pfam | PF02826; 2-Hacid_dh_C; 1; |
Features
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| From: GHRA_ECOLI (P75913) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 227 | 227 | R | |||||||||
| ACT_SITE | 275 | 275 | /note="Proton donor" | H | ||||||||
Additional information
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| Size range | 312-325 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |