HAMAP rule MF_01666

General rule information [?]

Accession	MF_01666
Dates	5-AUG-2008 (Created) 7-OCT-2022 (Last updated, Version 12)

Name	2_Hacid_dh_C_GhrA

Scope

Bacteria; Enterobacterales

Template

P75913 (GHRA_ECOLI)

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

GHRA

Protein name

RecName:		Full=Glyoxylate/hydroxypyruvate reductase A;
		EC 1.1.1.81;
		EC 1.1.1.79;
AltName:		Full=2-ketoacid reductase;

Gene name

ghrA

Comments [?]

Function	Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.
Catalytic activity	RHEA:10992: glycolate + NADP(+) = glyoxylate + H(+) + NADPH EC 1.1.1.79
	RHEA:17905: (R)-glycerate + NAD(+) = 3-hydroxypyruvate + H(+) + NADH EC 1.1.1.81
	RHEA:18657: (R)-glycerate + NADP(+) = 3-hydroxypyruvate + H(+) + NADPH EC 1.1.1.81
Subcellular location	Cytoplasm.
Similarity	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily.

Keywords [?]

Gene Ontology [?]

GO:0016618; Molecular function: hydroxypyruvate reductase activity.
GO:0030267; Molecular function: glyoxylate reductase (NADP+) activity.

Cross-references [?]

Features [?]

From: GHRA_ECOLI (P75913)

Key From To Description Tag Condition FTGroup

ACT_SITE 227 227 R

ACT_SITE 275 275 Proton donor H

Additional information [?]