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HAMAP rule MF_01670

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General rule information [?]

Accession MF_01670
Dates 29-SEP-2008 (Created)
28-JUL-2023 (Last updated, Version 16)
Name IolA
Scope(s) Bacteria
Bacillota
Template(s) P42412 (IOLA_BACSU); [ Recover all ]
Triggered by HAMAP; MF_01670 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier IOLA
Protein name RecName: Full=Malonate-semialdehyde dehydrogenase;
                 Short=MSA dehydrogenase;
                 EC=1.2.1.27;
AltName: Full=Methylmalonate semialdehyde dehydrogenase;
                 Short=MMSA dehydrogenase;
                 Short=MSDH;
Gene name Name=iolA;

Comments [?]

FUNCTIONCatalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively. Is involved in a myo-inositol catabolic pathway. Bicarbonate, and not CO2, is the end-product of the enzymatic reaction.
CATALYTIC ACTIVITY Reaction=3-oxopropanoate + CoA + H2O + NAD(+) = acetyl-CoA + H(+) + hydrogencarbonate + NADH; Xref=Rhea:RHEA:76615, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17544, ChEBI:CHEBI:33190, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.27; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76616;
CATALYTIC ACTIVITY Reaction=2-methyl-3-oxopropanoate + CoA + H2O + NAD(+) = H(+) + hydrogencarbonate + NADH + propanoyl-CoA; Xref=Rhea:RHEA:20804, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17544, ChEBI:CHEBI:57287, ChEBI:CHEBI:57392, ChEBI:CHEBI:57540, ChEBI:CHEBI:57700, ChEBI:CHEBI:57945; EC=1.2.1.27; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20805;
PATHWAYPolyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 7/7.
SUBUNITHomotetramer.
SIMILARITYBelongs to the aldehyde dehydrogenase family. IolA subfamily.

Keywords [?]


Gene Ontology [?]

GO:0004491; Molecular function:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity
GO:0018478; Molecular function:malonate-semialdehyde dehydrogenase (acetylating) activity
GO:0019310; Biological process:inositol catabolic process

Cross-references [?]

PROSITE PS00070; ALDEHYDE_DEHYDR_CYS; 1;
PROSITE PS00687; ALDEHYDE_DEHYDR_GLU; 1;
Pfam PF00171; Aldedh; 1;
NCBIfam TIGR01722; MMSDH; 1;

Features [?]

From: IOLA_BACSU (P42412)
Key From To Description Tag Condition FTGroup
BINDING 150 150 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"
A
BINDING 152 152 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"
F
BINDING 176 176 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"
K
BINDING 179 179 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"
E
BINDING 180 180 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"
[KR]
BINDING 229 229 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"
T
BINDING 251 251 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"
T
BINDING 382 382 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"
E
ACT_SITE 284 284 /note="Nucleophile"

Additional information [?]

Size range 470-520 amino acids
Related rules None
Fusion Nter: None Cter: None



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