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Annotation rule MF_01670
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General rule information [?]

Accession MF_01670
Dates 29-SEP-2008 (Created)
19-NOV-2019 (Last updated, Version 9)
Name IolA
Scope
Bacteria; Firmicutes
Template P42412 (IOLA_BACSU)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
IOLA
Protein name
RecName: Full=Malonate-semialdehyde dehydrogenase;
Short=MSA dehydrogenase;
EC 1.2.1.-;
AltName: Full=Methylmalonate semialdehyde dehydrogenase;
Short=MMSA dehydrogenase;
Short=MSDH;
EC 1.2.1.27;
Gene name
iolA

Comments [?]

Function Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively.
Catalytic activity RHEA:22992: 3-oxopropanoate + CoA + NAD(+) = acetyl-CoA + CO2 + NADH
RHEA:20804: 2-methyl-3-oxopropanoate + CoA + H2O + NAD(+) = H(+) + hydrogencarbonate + NADH + propanoyl-CoA
EC 1.2.1.27
Pathway Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 7/7.
Subunit Homotetramer.
Similarity Belongs to the aldehyde dehydrogenase family. IolA subfamily.

Keywords [?]

NAD
Oxidoreductase

Gene Ontology [?]

GO:0004491; Molecular function: methylmalonate-semialdehyde dehydrogenase (acylating) activity.
GO:0018478; Molecular function: malonate-semialdehyde dehydrogenase (acetylating) activity.
GO:0019310; Biological process: inositol catabolic process.

Cross-references [?]

PROSITE PS00070; ALDEHYDE_DEHYDR_CYS; 1;
PS00687; ALDEHYDE_DEHYDR_GLU; 1;
Pfam PF00171; Aldedh; 1;
TIGRFAMs TIGR01722; MMSDH; 1;

Features [?]

From: IOLA_BACSU (P42412)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     176     180       NAD     K-[PT]-S-E-[KR]  
ACT_SITE     284     284       Nucleophile     C  
BINDING     382     382       NAD     E  

Additional information [?]

Size range 470-520 amino acids
Related rules None
Fusion None


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