HAMAP rule MF_01679
General rule information
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| Accession | MF_01679 |
| Dates | 22-OCT-2008 (Created)
30-APR-2024 (Last updated, Version 21) |
| Name | Salvage_MtnW |
| Scope(s) |
Bacteria Microcystis Bacillota |
| Template(s) | O31666 (MTNW_BACSU); Q5L1E2 (MTNW_GEOKA); A8YER2 (MTNW_MICAE); [ Recover all ] |
| Triggered by |
HAMAP; MF_01679 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MTNW |
| Protein name | RecName: Full=2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Short=DK-MTP-1-P enolase; EC=5.3.2.5; AltName: Full=RuBisCO-like protein; Short=RLP; |
| Gene name | Name=mtnW; |
Comments
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| FUNCTION | Catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) into 2-hydroxy-3-keto-5-methylthiopentenyl-1- phosphate (HK-MTPenyl-1-P). |
| CATALYTIC ACTIVITY | Reaction=5-methylsulfanyl-2,3-dioxopentyl phosphate = 2-hydroxy-5- methylsulfanyl-3-oxopent-1-enyl phosphate; Xref=Rhea:RHEA:18769, ChEBI:CHEBI:58828, ChEBI:CHEBI:59505; EC=5.3.2.5; |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.; |
| PATHWAY | Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 3/6. |
| SUBUNIT | Homodimer. |
| MISCELLANEOUS | Has no RuBP-carboxylation activity. |
| SIMILARITY | Belongs to the RuBisCO large chain family. Type IV subfamily. |
Keywords
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Gene Ontology
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| GO:0000287; Molecular function:magnesium ion binding |
| GO:0043715; Molecular function:2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity |
| GO:0019509; Biological process:L-methionine salvage from methylthioadenosine |
Cross-references
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| PROSITE | PS00157; RUBISCO_LARGE; 1; |
| Pfam | PF00016; RuBisCO_large; 1; |
| NCBIfam | TIGR03332; Salvage_mtnW; 1; |
Features
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| From: MTNW_GEOKA (Q5L1E2) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 173 | 176 | /ligand="substrate" | |||||||||
| BINDING | 359 | 360 | /ligand="substrate" | |||||||||
| ACT_SITE | 98 | 98 | /note="Proton acceptor" | K | ||||||||
| BINDING | 173 | 173 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /note="via carbamate group" |
K | ||||||||
| BINDING | 175 | 175 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
D | ||||||||
| BINDING | 176 | 176 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
E | ||||||||
| BINDING | 147 | 147 | /ligand="substrate" | K | ||||||||
| BINDING | 264 | 264 | /ligand="substrate" | H | ||||||||
| BINDING | 337 | 337 | /ligand="substrate" | G | ||||||||
| MOD_RES | 173 | 173 | /note="N6-carboxylysine" | K | ||||||||
Additional information
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| Size range | 374-414 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |