HAMAP rule MF_01679
General rule information
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Accession | MF_01679 |
Dates | 22-OCT-2008 (Created)
30-APR-2024 (Last updated, Version 21) |
Name | Salvage_MtnW |
Scope(s) |
Bacteria Microcystis Bacillota |
Template(s) | O31666 (MTNW_BACSU); Q5L1E2 (MTNW_GEOKA); A8YER2 (MTNW_MICAE); [ Recover all ] |
Triggered by |
HAMAP; MF_01679 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | MTNW |
Protein name | RecName: Full=2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Short=DK-MTP-1-P enolase; EC=5.3.2.5; AltName: Full=RuBisCO-like protein; Short=RLP; |
Gene name | Name=mtnW; |
Comments
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FUNCTION | Catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) into 2-hydroxy-3-keto-5-methylthiopentenyl-1- phosphate (HK-MTPenyl-1-P). |
CATALYTIC ACTIVITY | Reaction=5-methylsulfanyl-2,3-dioxopentyl phosphate = 2-hydroxy-5- methylsulfanyl-3-oxopent-1-enyl phosphate; Xref=Rhea:RHEA:18769, ChEBI:CHEBI:58828, ChEBI:CHEBI:59505; EC=5.3.2.5; |
COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.; |
PATHWAY | Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 3/6. |
SUBUNIT | Homodimer. |
MISCELLANEOUS | Has no RuBP-carboxylation activity. |
SIMILARITY | Belongs to the RuBisCO large chain family. Type IV subfamily. |
Keywords
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Gene Ontology
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GO:0000287; Molecular function:magnesium ion binding |
GO:0043715; Molecular function:2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity |
GO:0019509; Biological process:L-methionine salvage from methylthioadenosine |
Cross-references
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PROSITE | PS00157; RUBISCO_LARGE; 1; |
Pfam | PF00016; RuBisCO_large; 1; |
NCBIfam | TIGR03332; Salvage_mtnW; 1; |
Features
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From: MTNW_GEOKA (Q5L1E2) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 173 | 176 | /ligand="substrate" | |||||||||
BINDING | 359 | 360 | /ligand="substrate" | |||||||||
ACT_SITE | 98 | 98 | /note="Proton acceptor" | K | ||||||||
BINDING | 173 | 173 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /note="via carbamate group" |
K | ||||||||
BINDING | 175 | 175 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
D | ||||||||
BINDING | 176 | 176 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
E | ||||||||
BINDING | 147 | 147 | /ligand="substrate" | K | ||||||||
BINDING | 264 | 264 | /ligand="substrate" | H | ||||||||
BINDING | 337 | 337 | /ligand="substrate" | G | ||||||||
MOD_RES | 173 | 173 | /note="N6-carboxylysine" | K |
Additional information
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Size range | 374-414 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |