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| Annotation rule MF_01720 |
General rule information
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| Accession | MF_01720 |
| Dates | 14-NOV-2006 (Created) 19-NOV-2019 (Last updated, Version 24) |
| Name | ABC_ATPase_TM_MacB |
| Scope | Bacteria |
| Template | P75831 (MACB_ECOLI) |
| Triggered by | PROSITE; PS51267 |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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case <OC:Gammaproteobacteria>
| Function | Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. |
| Subunit | Homodimer. Part of the tripartite efflux system MacAB-TolC, which is composed of an inner membrane transporter, MacB, a periplasmic membrane fusion protein, MacA, and an outer membrane component, TolC. The complex forms a large protein conduit and can translocate molecules across both the inner and outer membranes. Interacts with MacA. |
| Subcellular location | Cell inner membrane; Multi-pass membrane protein. |
else case defined <Property:Membrane> and <Property:Membrane=2>
| Function | Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. |
| Subunit | Homodimer. |
| Subcellular location | Cell inner membrane; Multi-pass membrane protein. |
else
| Function | Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. |
| Subunit | Homodimer. |
| Subcellular location | Cell membrane; Multi-pass membrane protein. |
end case
| Similarity | Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3.A.1.122) family. |
Keywords
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case <OC:Gammaproteobacteria> or (defined <Property:Membrane> and <Property:Membrane=2>)
end case
Nucleotide-binding
Transport
Antibiotic resistance
Translocase
Membrane
Cell membrane
Transmembrane
Transmembrane helix
Transport
Antibiotic resistance
Translocase
Membrane
Cell membrane
Transmembrane
Transmembrane helix
Gene Ontology
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GO:0008559; Molecular function: ATPase-coupled xenobiotic transmembrane transporter activity.
GO:1990961; Biological process: xenobiotic detoxification by transmembrane export across the plasma membrane.
GO:0005887; Cellular component: integral component of plasma membrane.
GO:1990961; Biological process: xenobiotic detoxification by transmembrane export across the plasma membrane.
GO:0005887; Cellular component: integral component of plasma membrane.
Cross-references
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| Pfam | PF00005; ABC_tran; 1; |
| PF02687; FtsX; 1; | |
| PROSITE | PS00211; ABC_TRANSPORTER_1; 1; |
| PS50893; ABC_TRANSPORTER_2; 1; trigger=PRU00434; |
Computed features
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| General | Transmembrane; -; 3-5; trigger=yes; |
Additional information
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| Size range | 640-715 amino acids |
| Related rules | PRU01700 |
| Fusion | None |