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Annotation rule MF_01720
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General rule information [?]

Accession MF_01720
Dates 14-NOV-2006 (Created)
14-JAN-2021 (Last updated, Version 25)
Name ABC_ATPase_TM_MacB
Scope
Bacteria
Template P75831 (MACB_ECOLI)
Triggered by PROSITE; PS51267

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MACB
Protein name
RecName: Full=Macrolide export ATP-binding/permease protein MacB;
EC 7.6.2.-;
Gene name
macB

Comments [?]

case <OC:Gammaproteobacteria>
Function Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
Subunit Homodimer. Part of the tripartite efflux system MacAB-TolC, which is composed of an inner membrane transporter, MacB, a periplasmic membrane fusion protein, MacA, and an outer membrane component, TolC. The complex forms a large protein conduit and can translocate molecules across both the inner and outer membranes. Interacts with MacA.
Subcellular location Cell inner membrane; Multi-pass membrane protein.
else case defined <Property:Membrane> and <Property:Membrane=2>
Function Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
Subunit Homodimer.
Subcellular location Cell inner membrane; Multi-pass membrane protein.
else
Function Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
Subunit Homodimer.
Subcellular location Cell membrane; Multi-pass membrane protein.
end case
Similarity Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3.A.1.122) family.

Keywords [?]

ATP-binding
case <OC:Gammaproteobacteria> or (defined <Property:Membrane> and <Property:Membrane=2>)
Cell inner membrane
end case
Nucleotide-binding
Transport
Antibiotic resistance
Translocase
Membrane
Cell membrane
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0008559; Molecular function: ABC-type xenobiotic transporter activity.
GO:1990961; Biological process: xenobiotic detoxification by transmembrane export across the plasma membrane.
GO:0005887; Cellular component: integral component of plasma membrane.

Cross-references [?]

Pfam PF00005; ABC_tran; 1;
PF02687; FtsX; 1;
PROSITE PS00211; ABC_TRANSPORTER_1; 1;
PS50893; ABC_TRANSPORTER_2; 1; trigger=PRU00434;

Computed features [?]

General Transmembrane; -; 3-5; trigger=yes;

Additional information [?]

Size range 640-715 amino acids
Related rules PRU01700
Fusion None


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