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Annotation rule MF_01720 |
General rule information
[?]
Accession |
MF_01720 |
Dates |
14-NOV-2006 (Created) 19-NOV-2019 (Last updated, Version 24) |
Propagated annotation
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Identifier, protein and gene names
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Protein name |
RecName:
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Full=Macrolide export ATP-binding/permease protein MacB;
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EC 7.6.2.-;
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case <OC:Gammaproteobacteria>
Function |
Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. |
Subunit |
Homodimer. Part of the tripartite efflux system MacAB-TolC, which is composed of an inner membrane transporter, MacB, a periplasmic membrane fusion protein, MacA, and an outer membrane component, TolC. The complex forms a large protein conduit and can translocate molecules across both the inner and outer membranes. Interacts with MacA. |
Subcellular location |
Cell inner membrane; Multi-pass membrane protein. |
else case defined <Property:Membrane> and <Property:Membrane=2>
Function |
Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. |
Subunit |
Homodimer. |
Subcellular location |
Cell inner membrane; Multi-pass membrane protein. |
else
Function |
Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. |
Subunit |
Homodimer. |
Subcellular location |
Cell membrane; Multi-pass membrane protein. |
end case
Similarity |
Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3.A.1.122) family. |
case <OC:Gammaproteobacteria> or (defined <Property:Membrane> and <Property:Membrane=2>)
end case
GO:0008559; Molecular function: ATPase-coupled xenobiotic transmembrane transporter activity.
GO:1990961; Biological process: xenobiotic detoxification by transmembrane export across the plasma membrane.
GO:0005887; Cellular component: integral component of plasma membrane.
General |
Transmembrane; -; 3-5; trigger=yes; |
Additional information
[?]
Size range |
640-715 amino acids |
Related rules |
PRU01700 |
Fusion |
None |