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HAMAP rule MF_01813

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General rule information [?]

Accession MF_01813
Dates 6-OCT-2003 (Created)
1-JUN-2023 (Last updated, Version 34)
Name MenG_UbiE_methyltr
Scope
Bacteria; except Cyanobacteriota
Archaea
Templates P31113 (MENG_BACSU); P0A887 (UBIE_ECOLI); P49017 (COQ5_YEAST): [Recover all]
case <OC:Bacteria> or <OC:Archaea>
Triggered by
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

case <OC:Pseudomonadota>
Identifier
UBIE
Protein name
RecName: Full=Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE;
EC 2.1.1.163;
EC 2.1.1.201;
AltName: Full=2-methoxy-6-polyprenyl-1,4-benzoquinol methylase;
AltName: Full=Demethylmenaquinone methyltransferase;
Gene name
ubiE
else
Identifier
MENG
Protein name
RecName: Full=Demethylmenaquinone methyltransferase;
EC 2.1.1.163;
Gene name
menG
end case

Comments [?]

case <OC:Pseudomonadota>
Function Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
Catalytic activity RHEA:42640: a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H(+) + S-adenosyl-L-homocysteine
EC 2.1.1.163
RHEA:28286: a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine
EC 2.1.1.201
Pathway Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 2/2.
Cofactor biosynthesis; ubiquinone biosynthesis.
else
Function Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).
Catalytic activity RHEA:42640: a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H(+) + S-adenosyl-L-homocysteine
EC 2.1.1.163
Pathway Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 2/2.
end case
Similarity Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.

Keywords [?]

Menaquinone biosynthesis
case <OC:Pseudomonadota>
Ubiquinone biosynthesis
end case
S-adenosyl-L-methionine
Transferase
Methyltransferase

Gene Ontology [?]

case <OC:Pseudomonadota>
GO:0008425; Molecular function: 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity.
GO:0009060; Biological process: aerobic respiration.
end case
GO:0009234; Biological process: menaquinone biosynthetic process.

Cross-references [?]

Pfam PF01209; Ubie_methyltran; 1;
NCBIfam TIGR01934; MenG_MenH_UbiE; 1;
PROSITE PS51608; SAM_MT_UBIE; 1;
PS01183; UBIE_1; 1;
PS01184; UBIE_2; 1;

Features [?]

From: COQ5_YEAST (P49017)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     179     180       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     [ND]-x  
BINDING     122     122       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     [ST]  
BINDING     148     148       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     D  
BINDING     197     197       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     S  

Additional information [?]

Size range 220-352 amino acids
Related rules MF_03192 (MENG supersedes the current rule); MF_01982 (MENG supersedes the current rule)
Fusion None


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