HAMAP rule MF_01813
General rule information
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Accession | MF_01813 |
Dates | 6-OCT-2003 (Created) 1-JUN-2023 (Last updated, Version 34) |
Name | MenG_UbiE_methyltr |
Scope | Bacteria; except Cyanobacteriota
Archaea |
Templates | P31113 (MENG_BACSU); P0A887 (UBIE_ECOLI); P49017 (COQ5_YEAST): [Recover all] |
case <OC:Bacteria> or <OC:Archaea>
Triggered by |
end case
Propagated annotation
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Identifier, protein and gene names
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case <OC:Pseudomonadota>
Identifier |
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Protein name |
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Gene name |
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else
Identifier |
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Protein name |
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Gene name |
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end case
Comments
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case <OC:Pseudomonadota>
Function | Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2). |
Catalytic activity | RHEA:42640: a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H(+) + S-adenosyl-L-homocysteine
EC 2.1.1.163 |
RHEA:28286: a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine
EC 2.1.1.201 |
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Pathway | Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 2/2. |
Cofactor biosynthesis; ubiquinone biosynthesis. |
else
Function | Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). |
Catalytic activity | RHEA:42640: a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H(+) + S-adenosyl-L-homocysteine
EC 2.1.1.163 |
Pathway | Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 2/2. |
end case
Similarity | Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family. |
Keywords
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case <OC:Pseudomonadota>
end case
Gene Ontology
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case <OC:Pseudomonadota>
GO:0008425; Molecular function: 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity.
GO:0009060; Biological process: aerobic respiration.
GO:0009060; Biological process: aerobic respiration.
end case
GO:0009234; Biological process: menaquinone biosynthetic process.
Cross-references
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Pfam | PF01209; Ubie_methyltran; 1; |
NCBIfam | TIGR01934; MenG_MenH_UbiE; 1; |
PROSITE | PS51608; SAM_MT_UBIE; 1; |
PS01183; UBIE_1; 1; | |
PS01184; UBIE_2; 1; |
Features
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From: COQ5_YEAST (P49017) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 179 | 180 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | [ND]-x | ||||||||
BINDING | 122 | 122 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | [ST] | ||||||||
BINDING | 148 | 148 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | D | ||||||||
BINDING | 197 | 197 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | S |
Additional information
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Size range | 220-352 amino acids |
Related rules | MF_03192 (MENG supersedes the current rule); MF_01982 (MENG supersedes the current rule) |
Fusion | None |