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Annotation rule MF_01846
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General rule information [?]

Accession MF_01846
Dates 26-MAY-2008 (Created)
19-NOV-2019 (Last updated, Version 15)
Name Nudix_NudI
Scope
Bacteria; Enterobacterales
Template P52006 (NUDI_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
NUDI
Protein name
RecName: Full=Nucleoside triphosphatase NudI;
EC 3.6.1.9;
AltName: Full=Nucleotide diphosphatase NudI;
AltName: Full=dCTP diphosphatase;
EC 3.6.1.12;
AltName: Full=dTTP diphosphatase;
EC 3.6.1.-;
AltName: Full=dUTP diphosphatase;
EC 3.6.1.23;
AltName: Full=Pyrimidine deoxynucleoside triphosphate diphosphatase;
Gene name
nudI

Comments [?]

Function Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP).
Catalytic activity RHEA:23996: a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-phosphate + diphosphate + H(+)
EC 3.6.1.9
RHEA:44644: a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+)
EC 3.6.1.9
RHEA:10248: dUTP + H2O = diphosphate + dUMP + H(+)
EC 3.6.1.23
RHEA:28534: dTTP + H2O = diphosphate + dTMP + H(+)
RHEA:22636: dCTP + H2O = dCMP + diphosphate + H(+)
EC 3.6.1.12
Cofactor Mg(2+)
Subunit Monomer.
Similarity Belongs to the Nudix hydrolase family. NudI subfamily.

Keywords [?]

Hydrolase
Magnesium

Gene Ontology [?]

GO:0047429; Molecular function: nucleoside-triphosphate diphosphatase activity.
GO:0000287; Molecular function: magnesium ion binding.

Cross-references [?]

Pfam PF00293; NUDIX; 1;
PRINTS PR00502; NUDIXFAMILY; 1;
PROSITE PS51462; NUDIX; 1; trigger=PRU00794;
PS00893; NUDIX_BOX; 1;

Features [?]

From: NUDI_ECOLI (P52006)
Key     From     To       Description   Tag   Condition   FTGroup
MOTIF     38     59       Nudix box        

Additional information [?]

Size range 140-141 amino acids
Related rules None
Fusion None


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