HAMAP rule MF_01846
General rule information
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| Accession | MF_01846 |
| Dates | 26-MAY-2008 (Created)
29-JUN-2022 (Last updated, Version 16) |
| Name | Nudix_NudI |
| Scope(s) |
Bacteria Enterobacterales |
| Template(s) | P52006 (NUDI_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01846 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | NUDI |
| Protein name | RecName: Full=Nucleoside triphosphatase NudI; EC=3.6.1.9; AltName: Full=Nucleotide diphosphatase NudI; AltName: Full=dCTP diphosphatase; EC=3.6.1.12; AltName: Full=dTTP diphosphatase; EC=3.6.1.-; AltName: Full=dUTP diphosphatase; EC=3.6.1.23; AltName: Full=Pyrimidine deoxynucleoside triphosphate diphosphatase; |
| Gene name | Name=nudI; |
Comments
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| FUNCTION | Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP). |
| CATALYTIC ACTIVITY | Reaction=a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'- phosphate + diphosphate + H(+); Xref=Rhea:RHEA:23996, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:58043, ChEBI:CHEBI:61557; EC=3.6.1.9; |
| CATALYTIC ACTIVITY | Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'- deoxyribonucleoside 5'-phosphate + diphosphate + H(+); Xref=Rhea:RHEA:44644, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:65317; EC=3.6.1.9; |
| CATALYTIC ACTIVITY | Reaction=dUTP + H2O = diphosphate + dUMP + H(+); Xref=Rhea:RHEA:10248, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:61555, ChEBI:CHEBI:246422; EC=3.6.1.23; |
| CATALYTIC ACTIVITY | Reaction=dTTP + H2O = diphosphate + dTMP + H(+); Xref=Rhea:RHEA:28534, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37568, ChEBI:CHEBI:63528; |
| CATALYTIC ACTIVITY | Reaction=dCTP + H2O = dCMP + diphosphate + H(+); Xref=Rhea:RHEA:22636, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:57566, ChEBI:CHEBI:61481; EC=3.6.1.12; |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
| SUBUNIT | Monomer. |
| SIMILARITY | Belongs to the Nudix hydrolase family. NudI subfamily. |
Keywords
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Gene Ontology
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| GO:0047429; Molecular function:nucleoside triphosphate diphosphatase activity |
| GO:0000287; Molecular function:magnesium ion binding |
Cross-references
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| Pfam | PF00293; NUDIX; 1; |
| PRINTS | PR00502; NUDIXFAMILY; 1; |
| PROSITE | PS51462; NUDIX; 1; |
| PROSITE | PS00893; NUDIX_BOX; 1; |
Features
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| From: NUDI_ECOLI (P52006) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| MOTIF | 38 | 59 | /note="Nudix box" | |||||||||
Additional information
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| Size range | 140-141 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |