Function |
Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP). |
Catalytic activity |
RHEA:23996: a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-phosphate + diphosphate + H(+)
EC 3.6.1.9
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RHEA:44644: a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+)
EC 3.6.1.9
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RHEA:10248: dUTP + H2O = diphosphate + dUMP + H(+)
EC 3.6.1.23
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RHEA:28534: dTTP + H2O = diphosphate + dTMP + H(+)
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RHEA:22636: dCTP + H2O = dCMP + diphosphate + H(+)
EC 3.6.1.12
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Cofactor |
Mg(2+) |
Subunit |
Monomer. |
Similarity |
Belongs to the Nudix hydrolase family. NudI subfamily. |