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HAMAP rule MF_01881

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General rule information [?]

Accession MF_01881
Dates 23-JUL-2010 (Created)
14-MAY-2024 (Last updated, Version 15)
Name Propion_kin_subfam1
Scope(s) Bacteria
Enterobacterales
Template(s) P11868 (TDCD_ECOLI); O06961 (TDCD_SALTY); [ Recover all ]
Triggered by HAMAP; MF_01881 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier TDCD
Protein name RecName: Full=Propionate kinase;
                 EC=2.7.2.15;
Gene name Name=tdcD;

Comments [?]

FUNCTIONCatalyzes the conversion of propionyl phosphate and ADP to propionate and ATP.
CATALYTIC ACTIVITY Reaction=ATP + propanoate = ADP + propanoyl phosphate; Xref=Rhea:RHEA:23148, ChEBI:CHEBI:17272, ChEBI:CHEBI:30616, ChEBI:CHEBI:58933, ChEBI:CHEBI:456216; EC=2.7.2.15;
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
PATHWAYAmino-acid degradation; L-threonine degradation via propanoate pathway; propanoate from L-threonine: step 4/4.
SUBUNITHomodimer.
SIMILARITYBelongs to the acetokinase family. TdcD subfamily.

Keywords [?]


Gene Ontology [?]

GO:0008980; Molecular function:propionate kinase activity
GO:0070689; Biological process:L-threonine catabolic process to propionate
GO:0016310; Biological process:phosphorylation

Cross-references [?]

Pfam PF00871; Acetate_kinase; 1;
PRINTS PR00471; ACETATEKNASE; 1;
NCBIfam TIGR00016; AckA; 1;
PIRSF PIRSF000722; Acetate_prop_kin; 1;
PROSITE PS01075; ACETATE_KINASE_1; 1;
PROSITE PS01076; ACETATE_KINASE_2; 1;

Features [?]

From: TDCD_SALTY (O06961)
Key From To Description Tag Condition FTGroup
BINDING 203 207 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
H-L-G-N-G
BINDING 278 280 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
D-[LM]-R
BINDING 326 330 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
G-I-G-E-N
ACT_SITE 143 143 /note="Proton donor/acceptor" D
BINDING 11 11 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
N
BINDING 381 381 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
D
BINDING 11 11 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
N
BINDING 18 18 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
K
BINDING 86 86 /ligand="substrate" R
BINDING 175 175 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
H
BINDING 326 326 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
G
SITE 175 175 /note="Transition state stabilizer" H
SITE 236 236 /note="Transition state stabilizer" R

Additional information [?]

Size range 372-418 amino acids
Related rules MF_00020
Fusion Nter: None Cter: None



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