HAMAP rule MF_01913
General rule information
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Accession | MF_01913 |
Dates | 31-MAR-2014 (Created) 19-NOV-2022 (Last updated, Version 12) |
Name | SLA_reductase |
Scope | Bacteria; Enterobacterales |
Template | P0A9V8 (SQUU_ECOLI) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Comments
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Function | Reduces 3-sulfolactaldehyde (SLA) to 2,3-dihydroxypropane 1-sulfonate (DHPS). |
Catalytic activity | RHEA:40511: (2S)-3-sulfopropanediol + NAD(+) = (2S)-3-sulfolactaldehyde + H(+) + NADH
EC 1.1.1.373 PhysiologicalDirection=right-to-left (RHEA:40513) |
Similarity | Belongs to the HIBADH-related family. 3-sulfolactaldehyde reductase subfamily. |
Keywords
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Gene Ontology
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GO:0061596; Molecular function: 3-sulfolactaldehyde reductase activity.
GO:1902777; Biological process: 6-sulfoquinovose(1-) catabolic process.
GO:1902777; Biological process: 6-sulfoquinovose(1-) catabolic process.
Cross-references
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PROSITE | PS00895; 3_HYDROXYISOBUT_DH; 1; |
Pfam | PF03446; NAD_binding_2; 1; |
PIRSF | PIRSF000103; HIBADH; 1; |
Features
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From: SQUU_ECOLI (P0A9V8) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 11 | 12 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | Q-M | ||||||||
BINDING | 174 | 178 | /ligand="2,3-dihydroxypropane-1-sulfonate" /ligand_id="ChEBI:CHEBI:77138 | N-N-Y-M-S | ||||||||
ACT_SITE | 171 | 171 | K | |||||||||
BINDING | 31 | 31 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | D | ||||||||
BINDING | 65 | 65 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | L | ||||||||
BINDING | 96 | 96 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | T | ||||||||
BINDING | 123 | 123 | /ligand="2,3-dihydroxypropane-1-sulfonate" /ligand_id="ChEBI:CHEBI:77138 | R | ||||||||
BINDING | 240 | 240 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | K |
Additional information
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Size range | 280-320 amino acids |
Related rules | None |
Fusion | None |