HAMAP rule MF_01913
General rule information
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| Accession | MF_01913 |
| Dates | 31-MAR-2014 (Created)
19-NOV-2022 (Last updated, Version 12) |
| Name | SLA_reductase |
| Scope(s) |
Bacteria Enterobacterales |
| Template(s) | P0A9V8 (SQUU_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01913 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | SQUU |
| Protein name | RecName: Full=3-sulfolactaldehyde reductase; Short=SLA reductase; EC=1.1.1.373; |
Comments
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| FUNCTION | Reduces 3-sulfolactaldehyde (SLA) to 2,3-dihydroxypropane 1- sulfonate (DHPS). |
| CATALYTIC ACTIVITY | Reaction=(2S)-3-sulfopropanediol + NAD(+) = (2S)-3-sulfolactaldehyde + H(+) + NADH; Xref=Rhea:RHEA:40511, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90109, ChEBI:CHEBI:176527; EC=1.1.1.373; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:40513; |
| SIMILARITY | Belongs to the HIBADH-related family. 3-sulfolactaldehyde reductase subfamily. |
Keywords
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Gene Ontology
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| GO:0061596; Molecular function:3-sulfolactaldehyde reductase activity |
| GO:1902777; Biological process:6-sulfoquinovose(1-) catabolic process |
Cross-references
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| PROSITE | PS00895; 3_HYDROXYISOBUT_DH; 1; |
| Pfam | PF03446; NAD_binding_2; 1; |
| PIRSF | PIRSF000103; HIBADH; 1; |
Features
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| From: SQUU_ECOLI (P0A9V8) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 11 | 12 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
Q-M | ||||||||
| BINDING | 174 | 178 | /ligand="2,3-dihydroxypropane-1-sulfonate" /ligand_id="ChEBI:CHEBI:77138" |
N-N-Y-M-S | ||||||||
| ACT_SITE | 171 | 171 | K | |||||||||
| BINDING | 31 | 31 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
D | ||||||||
| BINDING | 65 | 65 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
L | ||||||||
| BINDING | 96 | 96 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
T | ||||||||
| BINDING | 123 | 123 | /ligand="2,3-dihydroxypropane-1-sulfonate" /ligand_id="ChEBI:CHEBI:77138" |
R | ||||||||
| BINDING | 240 | 240 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
K | ||||||||
Additional information
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| Size range | 280-320 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |