HAMAP rule MF_01920

General rule information [?]

Accession	MF_01920
Dates	12-MAY-2014 (Created) 1-JUN-2023 (Last updated, Version 10)
Name	Helicase_Rep
Scope(s)	Bacteria Pseudomonadota
Template(s)	P09980 (REP_ECOLI); [ Recover all ]
Triggered by	HAMAP; MF_01920 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	REP
RecName: Full=ATP-dependent DNA helicase Rep;<br />                  EC=<a href="https://enzyme.expasy.org/EC/5.6.2.4">5.6.2.4</a>;<br /> AltName: Full=DNA 3'-5' helicase Rep;
Gene name	Name=rep;

Comments [?]

FUNCTION	Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction.
CATALYTIC ACTIVITY	Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.; EC=5.6.2.4;
CATALYTIC ACTIVITY	Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
SUBUNIT	Homodimer.
SIMILARITY	Belongs to the helicase family. UvrD subfamily.

Keywords [?]

ATP-binding
DNA replication
DNA-binding
<a href="https://www.uniprot.org/keywords/KW-0347">Helicase</a>
Hydrolase
Nucleotide-binding
Isomerase

Gene Ontology [?]

GO:0003678; Molecular function:DNA helicase activity

GO:0005524; Molecular function:ATP binding

GO:0003697; Molecular function:single-stranded DNA binding

GO:0006268; Biological process:DNA unwinding involved in DNA replication

Cross-references [?]

Features [?]

From: REP_ECOLI (P09980)

Key

From

Description

Tag

Condition

FTGroup

BINDING

278

/ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"

Additional information [?]