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HAMAP rule MF_01968

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General rule information [?]

Accession MF_01968
Dates 2-APR-2012 (Created)
19-NOV-2022 (Last updated, Version 11)
Name Sirtuin_ClassU
Scope(s) Bacteria
Archaea
Template(s) Q9WYW0 (NPD_THEMA); [ Recover all ]
Triggered by
case c? <OC:Bacteria> or <OC:Archaea>
HAMAP; MF_01968 (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier NPD
Protein name RecName: Full=NAD-dependent protein deacetylase;
                 EC=2.3.1.286;
AltName: Full=Regulatory protein SIR2 homolog;
Gene name Name=cobB;

Comments [?]

case <OC:Archaea>
FUNCTIONNAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription.
else
FUNCTIONNAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.
end case
CATALYTIC ACTIVITY Reaction=H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl- ADP-D-ribose + L-lysyl-[protein] + nicotinamide; Xref=Rhea:RHEA:43636, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15377, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:61930, ChEBI:CHEBI:83767; EC=2.3.1.286;
case <FTGroup:1>
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
end case
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the sirtuin family. Class U subfamily.

Keywords [?]

Cytoplasm
NAD
case <FTGroup:1>
Metal-binding
Zinc
end case
case <OC:Archaea>
Transcription
Transcription regulation
end case
Transferase

Gene Ontology [?]

GO:0005737; Cellular component:cytoplasm
GO:0034979; Molecular function:NAD-dependent protein deacetylase activity
GO:0070403; Molecular function:NAD+ binding
GO:0006476; Biological process:protein deacetylation
case <FTGroup:1>
GO:0008270; Molecular function:zinc ion binding
end case

Cross-references [?]

PROSITE PS50305; SIRTUIN; 1;
Pfam PF02146; SIR2; 1;

Features [?]

From: NPD_THEMA (Q9WYW0)
Key From To Description Tag Condition FTGroup
ACT_SITE 116 116 /note="Proton acceptor" H
BINDING 22 22 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"		 A
BINDING 26 26 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"		 T
BINDING 33 33 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"		 [FY]
BINDING 33 33 /ligand="nicotinamide"
/ligand_id="ChEBI:CHEBI:17154"		 [FY]
BINDING 34 34 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"		 R
BINDING 98 98 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"		 Q
BINDING 100 100 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"		 [IVT]
BINDING 100 100 /ligand="nicotinamide"
/ligand_id="ChEBI:CHEBI:17154"		 [IVT]
BINDING 101 101 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"		 D
BINDING 101 101 /ligand="nicotinamide"
/ligand_id="ChEBI:CHEBI:17154"		 D
BINDING 116 116 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"		 H
BINDING 124 124 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1
BINDING 127 127 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1
BINDING 148 148 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1
BINDING 151 151 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1
BINDING 189 189 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"		 [ST]
BINDING 190 190 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"		 S
BINDING 214 214 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"		 N
BINDING 215 215 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"		 [LAV]
BINDING 216 216 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"		 G
BINDING 231 231 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"		 [DE]
BINDING 232 232 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"		 [VGIA]

Additional information [?]

Size range 229-260 amino acids
Related rules MF_01121
MF_01967
Fusion Nter: None Cter: None



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