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Annotation rule MF_01968
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General rule information [?]

Accession MF_01968
Dates 2-APR-2012 (Created)
19-NOV-2019 (Last updated, Version 8)
Name Sirtuin_ClassU
Scope
Bacteria
Archaea
Template Q9WYW0 (NPD_THEMA)
case <OC:Bacteria> or <OC:Archaea>
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
NPD
Protein name
RecName: Full=NAD-dependent protein deacetylase;
EC 2.3.1.286;
AltName: Full=Regulatory protein SIR2 homolog;
Gene name
cobB

Comments [?]

case <OC:Archaea>
Function NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription.
else
Function NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.
end case
Catalytic activity RHEA:43636: H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
EC 2.3.1.286
case <FTGroup:1>
Cofactor Zn(2+)
Note: Binds 1 zinc ion per subunit.
end case
Subcellular location Cytoplasm.
Similarity Belongs to the sirtuin family. Class U subfamily.

Keywords [?]

case <FTGroup:1>
end case
case <OC:Archaea>
end case

Gene Ontology [?]

GO:0005737; Cellular component: cytoplasm.
GO:0034979; Molecular function: NAD-dependent protein deacetylase activity.
GO:0070403; Molecular function: NAD+ binding.
GO:0006476; Biological process: protein deacetylation.
case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
end case

Cross-references [?]

PROSITE PS50305; SIRTUIN; 1; trigger=PRU00236;
Pfam PF02146; SIR2; 1;

Features [?]

From: NPD_THEMA (Q9WYW0)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     21     40       NAD     G-A-G-x-S-[TV]-x-x-[GN]-[ILV]-[PK]-D-[FY]-R-x(6,7)  
NP_BIND     98     101       NAD     Q-N-[IV]-D  
NP_BIND     188     190       NAD     G-[ST]-S  
NP_BIND     214     216       NAD     N-x(2)  
ACT_SITE     116     116       Proton acceptor     H  
METAL     124     124       Zinc     C   1
METAL     127     127       Zinc     C   1
METAL     148     148       Zinc     C   1
METAL     151     151       Zinc     C   1

Additional information [?]

Size range 229-260 amino acids
Related rules MF_01121 (NPD supersedes the current rule); MF_01967 (NPD)
Fusion None