HAMAP rule MF_01968

General rule information [?]

Accession	MF_01968
Dates	2-APR-2012 (Created) 19-NOV-2022 (Last updated, Version 11)

Name	Sirtuin_ClassU

Scope

Bacteria

Archaea

Template

Q9WYW0 (NPD_THEMA)

case <OC:Bacteria> or <OC:Archaea>

Triggered by

HAMAP; MF_01968 (Get profile general information and statistics)

end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

NPD

Protein name

RecName:		Full=NAD-dependent protein deacetylase;
		EC 2.3.1.286;
AltName:		Full=Regulatory protein SIR2 homolog;

Gene name

cobB

Comments [?]

case <OC:Archaea>

Function

NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription.

else

Function

NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.

end case

Catalytic activity

RHEA:43636: H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
EC 2.3.1.286

case <FTGroup:1>

Cofactor

Zn(2+)
Note: Binds 1 zinc ion per subunit.

end case

Subcellular location	Cytoplasm.
Similarity	Belongs to the sirtuin family. Class U subfamily.

Keywords [?]

Cytoplasm
NAD

case <FTGroup:1>

Metal-binding
Zinc

end case

case <OC:Archaea>

Transcription
Transcription regulation

end case

Transferase

Gene Ontology [?]

GO:0005737; Cellular component: cytoplasm.
GO:0034979; Molecular function: NAD-dependent protein deacetylase activity.
GO:0070403; Molecular function: NAD+ binding.
GO:0006476; Biological process: protein deacetylation.

case <FTGroup:1>

GO:0008270; Molecular function: zinc ion binding.

end case

Cross-references [?]

PROSITE	PS50305; SIRTUIN; 1; trigger=PRU00236;
Pfam	PF02146; SIR2; 1;

Features [?]

From: NPD_THEMA (Q9WYW0)

Key From To Description Tag Condition FTGroup

ACT_SITE 116 116 Proton acceptor H

BINDING 22 22 /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 A

BINDING 26 26 /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 T

BINDING 33 33 /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 [FY]

BINDING 33 33 /ligand="nicotinamide" /ligand_id="ChEBI:CHEBI:17154 [FY]

BINDING 34 34 /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 R

BINDING 98 98 /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 Q

BINDING 100 100 /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 [IVT]

BINDING 100 100 /ligand="nicotinamide" /ligand_id="ChEBI:CHEBI:17154 [IVT]

BINDING 101 101 /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 D

BINDING 101 101 /ligand="nicotinamide" /ligand_id="ChEBI:CHEBI:17154 D

BINDING 116 116 /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 H

BINDING 124 124 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 C 1

BINDING 127 127 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 C 1

BINDING 148 148 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 C 1

BINDING 151 151 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 C 1

BINDING 189 189 /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 [ST]

BINDING 190 190 /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 S

BINDING 214 214 /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 N

BINDING (Optional) 215 215 /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 [LAV]

BINDING (Optional) 216 216 /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 G

BINDING (Optional) 231 231 /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 [DE]

BINDING (Optional) 232 232 /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 [VGIA]

Additional information [?]

Size range	229-260 amino acids
Related rules	MF_01121 (NPD supersedes the current rule); MF_01967 (NPD)
Fusion	None

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