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Annotation rule MF_01988 |
General rule information
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Accession |
MF_01988 |
Dates |
20-OCT-2016 (Created) 19-NOV-2019 (Last updated, Version 4) |
case <OC:Bacteria> or <OC:Archaea>
end case
Propagated annotation
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Identifier, protein and gene names
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Protein name |
RecName:
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Full=Succinate--CoA ligase [ADP-forming] subunit alpha;
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EC 6.2.1.5;
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AltName:
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Full=Succinyl-CoA synthetase subunit alpha;
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Short=SCS-alpha;
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Function |
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. |
Catalytic activity |
RHEA:17661: ATP + CoA + succinate = ADP + phosphate + succinyl-CoA
EC 6.2.1.5
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Pathway |
Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1. |
Subunit |
Heterotetramer of two alpha and two beta subunits. |
Similarity |
Belongs to the succinate/malate CoA ligase alpha subunit family. |
GO:0004775; Molecular function: succinate-CoA ligase (ADP-forming) activity.
GO:0006099; Biological process: tricarboxylic acid cycle.
From: SUCD_ECOLI (P0AGE9) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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REGION
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17
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20
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Coenzyme A binding
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T-G-x(2)
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REGION
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96
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98
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Coenzyme A binding
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[IVL]-T-[ED]
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ACT_SITE
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247
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247
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Tele-phosphohistidine intermediate
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H
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BINDING
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43
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43
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Coenzyme A
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K
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BINDING
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159
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159
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Substrate; shared with subunit beta
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Y
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Additional information
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Size range |
259-308 amino acids |
Related rules |
None |
Fusion |
None |