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HAMAP rule MF_01988

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General rule information [?]

Accession MF_01988
Dates 20-OCT-2016 (Created)
1-JUN-2023 (Last updated, Version 9)
Name Succ_CoA_alpha
Scope(s) Bacteria
Archaea
Template(s) P0AGE9 (SUCD_ECOLI); P09143 (SUCD_THETH); O19069 (SUCA_PIG); [ Recover all ]
Triggered by
case c? <OC:Bacteria> or <OC:Archaea>
HAMAP; MF_01988 (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier SUCD
Protein name RecName: Full=Succinate--CoA ligase [ADP-forming] subunit alpha;
                 EC=6.2.1.5;
AltName: Full=Succinyl-CoA synthetase subunit alpha;
                 Short=SCS-alpha;
Gene name Name=sucD;

Comments [?]

FUNCTIONSuccinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
CATALYTIC ACTIVITY Reaction=ATP + CoA + succinate = ADP + phosphate + succinyl-CoA; Xref=Rhea:RHEA:17661, ChEBI:CHEBI:30031, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57287, ChEBI:CHEBI:57292, ChEBI:CHEBI:456216; EC=6.2.1.5; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:17663;
CATALYTIC ACTIVITY Reaction=CoA + GTP + succinate = GDP + phosphate + succinyl-CoA; Xref=Rhea:RHEA:22120, ChEBI:CHEBI:30031, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:57287, ChEBI:CHEBI:57292, ChEBI:CHEBI:58189; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:22122;
PATHWAYCarbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.
SUBUNITHeterotetramer of two alpha and two beta subunits.
SIMILARITYBelongs to the succinate/malate CoA ligase alpha subunit family.

Keywords [?]


Gene Ontology [?]

GO:0004775; Molecular function:succinate-CoA ligase (ADP-forming) activity
GO:0006099; Biological process:tricarboxylic acid cycle

Cross-references [?]

PROSITE PS01216; SUCCINYL_COA_LIG_1; 1;
PROSITE PS00399; SUCCINYL_COA_LIG_2; 1;
Pfam PF02629; CoA_binding; 1;
Pfam PF00549; Ligase_CoA; 1;
Pfam PF13607; Succ_CoA_lig; 1;
PRINTS PR01798; SCOASYNTHASE; 1;
NCBIfam TIGR01019; sucCoAalpha; 1;
PIRSF PIRSF001553; SucCS_alpha; 1;

Features [?]

From: SUCD_ECOLI (P0AGE9)
Key From To Description Tag Condition FTGroup
BINDING 17 20 /ligand="CoA"
/ligand_id="ChEBI:CHEBI:57287"
T-G-x(2)
BINDING 96 98 /ligand="CoA"
/ligand_id="ChEBI:CHEBI:57287"
[IVL]-T-[ED]
ACT_SITE 247 247 /note="Tele-phosphohistidine intermediate" H
BINDING 43 43 /ligand="CoA"
/ligand_id="ChEBI:CHEBI:57287"
K
BINDING 159 159 /ligand="substrate"
/ligand_note="ligand shared with subunit beta"
Y

Additional information [?]

Size range 259-308 amino acids
Related rules None
Fusion Nter: None Cter: None



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