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Annotation rule MF_01988
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General rule information [?]

Accession MF_01988
Dates 20-OCT-2016 (Created)
19-NOV-2019 (Last updated, Version 4)
Name Succ_CoA_alpha
Scope
Bacteria
Archaea
Templates P0AGE9 (SUCD_ECOLI); P09143 (SUCD_THETH); O19069 (SUCA_PIG): [Recover all]
case <OC:Bacteria> or <OC:Archaea>
Triggered by
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
SUCD
Protein name
RecName: Full=Succinate--CoA ligase [ADP-forming] subunit alpha;
EC 6.2.1.5;
AltName: Full=Succinyl-CoA synthetase subunit alpha;
Short=SCS-alpha;
Gene name
sucD

Comments [?]

Function Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
Catalytic activity RHEA:17661: ATP + CoA + succinate = ADP + phosphate + succinyl-CoA
EC 6.2.1.5
Pathway Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.
Subunit Heterotetramer of two alpha and two beta subunits.
Similarity Belongs to the succinate/malate CoA ligase alpha subunit family.

Keywords [?]

Ligase
Nucleotide-binding
Tricarboxylic acid cycle

Gene Ontology [?]

GO:0004775; Molecular function: succinate-CoA ligase (ADP-forming) activity.
GO:0006099; Biological process: tricarboxylic acid cycle.

Cross-references [?]

PROSITE PS01216; SUCCINYL_COA_LIG_1; 1;
PS00399; SUCCINYL_COA_LIG_2; 1;
Pfam PF02629; CoA_binding; 1;
PF00549; Ligase_CoA; 1;
PF13607; Succ_CoA_lig; 1;
PRINTS PR01798; SCOASYNTHASE; 1;
TIGRFAMs TIGR01019; sucCoAalpha; 1;
PIRSF PIRSF001553; SucCS_alpha; 1;

Features [?]

From: SUCD_ECOLI (P0AGE9)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     17     20       Coenzyme A binding     T-G-x(2)  
REGION     96     98       Coenzyme A binding     [IVL]-T-[ED]  
ACT_SITE     247     247       Tele-phosphohistidine intermediate     H  
BINDING     43     43       Coenzyme A     K  
BINDING     159     159       Substrate; shared with subunit beta     Y  

Additional information [?]

Size range 259-308 amino acids
Related rules None
Fusion None


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