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HAMAP rule MF_02023

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General rule information [?]

Accession MF_02023
Dates 1-APR-2015 (Created)
26-JAN-2023 (Last updated, Version 10)
Name Sulfite_red
Scope
Bacteria; Pseudomonadota
Templates Q7MSJ8 (MCCA_WOLSU); Q8EJI6 (MCCA_SHEON): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MCCA
Protein name
RecName: Full=Dissimilatory sulfite reductase;
EC 1.8.99.-;
Flags: Precursor;

Comments [?]

Function Respiratory sulfite reductase that catalyzes the reduction of sulfite to sulfide in a single step, consuming six electrons in the process.
Catalytic activity RHEA:51676: [protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide = [protein]-dithiol + 2 AH2 + H(+) + sulfite
Cofactor Cu(+)
Note: Exposure to oxygen reduces copper binding and leads to the formation of a disulfide bond between the two Cys residues that bind the copper ion.
heme c
Note: Binds 8 heme c groups covalently per monomer.
Pathway Sulfur metabolism; sulfite reduction.
Subcellular location Periplasm.
Similarity Belongs to the multiheme cytochrome c family.

Keywords [?]

Copper
Electron transport
Heme
Iron
Metal-binding
Oxidoreductase
Periplasm
Signal
Sulfate respiration
Transport

Gene Ontology [?]

GO:0005507; Molecular function: copper ion binding.
GO:0020037; Molecular function: heme binding.
GO:0005506; Molecular function: iron ion binding.
GO:0016002; Molecular function: sulfite reductase activity.
GO:0070814; Biological process: hydrogen sulfide biosynthetic process.
GO:0042597; Cellular component: periplasmic space.

Cross-references [?]

PROSITE PS51008; MULTIHEME_CYTC; 2;
Pfam PF14522; Cytochrome_C7; 1;
PF09699; Paired_CXXCH_1; 1;

Computed features [?]

General Signal; -; 1; trigger=yes;

Features [?]

From: MCCA_WOLSU (Q7MSJ8)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     159     159       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="1" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue     H  
BINDING     171     171       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="4" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue     H  
BINDING     318     318       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="2" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue     H  
BINDING     355     355       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="3" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue     H  
BINDING     360     360       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="1" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue     H  
BINDING     376     376       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="4" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue     H  
BINDING     411     411       /ligand="Cu(+)" /ligand_id="ChEBI:CHEBI:49552     C  
BINDING     423     423       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="6" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue     H  
BINDING     434     434       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="5" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue     H  
BINDING     437     437       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="3" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue     H  
BINDING     478     478       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="6" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue     H  
BINDING     491     491       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="8" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue     H  
BINDING     500     500       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="7" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue     H  
BINDING     507     507       /ligand="Cu(+)" /ligand_id="ChEBI:CHEBI:49552     C  
BINDING     528     528       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="5" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue     H  
BINDING     591     591       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="8" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue     H  
BINDING     675     675       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="7" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue     H  
BINDING     155     155       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="1" /note="covalent     C  
BINDING     158     158       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="1" /note="covalent     C  
BINDING     220     220       /ligand="substrate     K  
BINDING     297     297       /ligand="substrate     Y  
BINDING     314     314       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="2" /note="covalent     C  
BINDING     317     317       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="2" /note="covalent     C  
BINDING     351     351       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="3" /note="covalent     C  
BINDING     354     354       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="3" /note="covalent     C  
BINDING     372     372       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="4" /note="covalent     C  
BINDING     375     375       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="4" /note="covalent     C  
BINDING     378     378       /ligand="substrate     R  
BINDING     430     430       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="5" /note="covalent     C  
BINDING     433     433       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="5" /note="covalent     C  
BINDING     474     474       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="6" /note="covalent     C  
BINDING     477     477       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="6" /note="covalent     C  
BINDING     496     496       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="7" /note="covalent     C  
BINDING     499     499       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="7" /note="covalent     C  
BINDING     574     574       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="8" /note="covalent     C  
BINDING     590     590       /ligand="heme c" /ligand_id="ChEBI:CHEBI:61717" /ligand_label="8" /note="covalent     C  

Additional information [?]

Size range 640-710 amino acids
Related rules None
Fusion None


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