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Annotation rule MF_02023
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General rule information [?]

Accession MF_02023
Dates 1-APR-2015 (Created)
19-JAN-2021 (Last updated, Version 5)
Name Sulfite_red
Scope
Bacteria; Proteobacteria
Templates Q7MSJ8 (MCCA_WOLSU); Q8EJI6 (MCCA_SHEON): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MCCA
Protein name
RecName: Full=Dissimilatory sulfite reductase;
EC 1.8.99.-;
Flags: Precursor;

Comments [?]

Function Respiratory sulfite reductase that catalyzes the reduction of sulfite to sulfide in a single step, consuming six electrons in the process.
Catalytic activity RHEA:51676: [protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide = [protein]-dithiol + 2 AH2 + H(+) + sulfite
Cofactor Cu(+)
Note: Exposure to oxygen reduces copper binding and leads to the formation of a disulfide bond between the two Cys residues that bind the copper ion.
heme
Note: Binds 8 heme groups covalently per monomer.
Pathway Sulfur metabolism; sulfite reduction.
Subcellular location Periplasm.
Similarity Belongs to the multiheme cytochrome c family.

Keywords [?]


Gene Ontology [?]

GO:0005507; Molecular function: copper ion binding.
GO:0020037; Molecular function: heme binding.
GO:0005506; Molecular function: iron ion binding.
GO:0016002; Molecular function: sulfite reductase activity.
GO:0070814; Biological process: hydrogen sulfide biosynthetic process.
GO:0042597; Cellular component: periplasmic space.

Cross-references [?]

PROSITE PS51008; MULTIHEME_CYTC; 2;
Pfam PF14522; Cytochrome_C7; 1;
PF09699; Paired_CXXCH_1; 1;

Computed features [?]

General Signal; -; 1; trigger=yes;

Features [?]

From: MCCA_WOLSU (Q7MSJ8)
Key     From     To       Description   Tag   Condition   FTGroup
METAL     159     159       Iron (heme 1 axial ligand); via tele nitrogen     H  
METAL     171     171       Iron (heme 4 axial ligand); via tele nitrogen     H  
METAL     318     318       Iron (heme 2 axial ligand); via tele nitrogen     H  
METAL     355     355       Iron (heme 3 axial ligand); via tele nitrogen     H  
METAL     360     360       Iron (heme 1 axial ligand); via tele nitrogen     H  
METAL     376     376       Iron (heme 4 axial ligand); via tele nitrogen     H  
METAL     411     411       Copper     C  
METAL     423     423       Iron (heme 6 axial ligand); via tele nitrogen     H  
METAL     434     434       Iron (heme 5 axial ligand); via tele nitrogen     H  
METAL     437     437       Iron (heme 3 axial ligand); via tele nitrogen     H  
METAL     478     478       Iron (heme 6 axial ligand); via tele nitrogen     H  
METAL     491     491       Iron (heme 8 axial ligand); via tele nitrogen     H  
METAL     500     500       Iron (heme 7 axial ligand); via tele nitrogen     H  
METAL     507     507       Copper     C  
METAL     528     528       Iron (heme 5 axial ligand); via tele nitrogen     H  
METAL     591     591       Iron (heme 8 axial ligand); via tele nitrogen     H  
METAL     675     675       Iron (heme 7 axial ligand); via tele nitrogen     H  
BINDING     155     155       Heme 1; covalent     C  
BINDING     158     158       Heme 1; covalent     C  
BINDING     220     220       Substrate     K  
BINDING     297     297       Substrate     Y  
BINDING     314     314       Heme 2; covalent     C  
BINDING     317     317       Heme 2; covalent     C  
BINDING     351     351       Heme 3; covalent     C  
BINDING     354     354       Heme 3; covalent     C  
BINDING     372     372       Heme 4; covalent     C  
BINDING     375     375       Heme 4; covalent     C  
BINDING     378     378       Substrate     R  
BINDING     430     430       Heme 5; covalent     C  
BINDING     433     433       Heme 5; covalent     C  
BINDING     474     474       Heme 6; covalent     C  
BINDING     477     477       Heme 6; covalent     C  
BINDING     496     496       Heme 7; covalent     C  
BINDING     499     499       Heme 7; covalent     C  
BINDING     574     574       Heme 8; covalent     C  
BINDING     590     590       Heme 8; covalent     C  

Additional information [?]

Size range 640-710 amino acids
Related rules None
Fusion None