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HAMAP rule MF_02023

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General rule information [?]

Accession MF_02023
Dates 1-APR-2015 (Created)
26-JAN-2023 (Last updated, Version 10)
Name Sulfite_red
Scope(s) Bacteria
Pseudomonadota
Template(s) Q7MSJ8 (MCCA_WOLSU); Q8EJI6 (MCCA_SHEON); [ Recover all ]
Triggered by HAMAP; MF_02023 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MCCA
Protein name RecName: Full=Dissimilatory sulfite reductase;
                 EC=1.8.99.-;
                 Flags: Precursor;

Comments [?]

FUNCTIONRespiratory sulfite reductase that catalyzes the reduction of sulfite to sulfide in a single step, consuming six electrons in the process.
CATALYTIC ACTIVITY Reaction=[protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide = [protein]-dithiol + 2 AH2 + H(+) + sulfite; Xref=Rhea:RHEA:51676, Rhea:RHEA-COMP:10593, Rhea:RHEA-COMP:10594, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17359, ChEBI:CHEBI:17499, ChEBI:CHEBI:29919, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058;
COFACTOR Name=Cu(+); Xref=ChEBI:CHEBI:49552; Note=Exposure to oxygen reduces copper binding and leads to the formation of a disulfide bond between the two Cys residues that bind the copper ion.;
COFACTOR Name=heme c; Xref=ChEBI:CHEBI:61717; Note=Binds 8 heme c groups covalently per monomer.;
PATHWAYSulfur metabolism; sulfite reduction.
SUBCELLULAR LOCATIONPeriplasm.
SIMILARITYBelongs to the multiheme cytochrome c family.

Keywords [?]

Copper
Electron transport
Heme
Iron
Metal-binding
Oxidoreductase
Periplasm
Signal
Sulfate respiration
Transport

Gene Ontology [?]

GO:0005507; Molecular function:copper ion binding
GO:0020037; Molecular function:heme binding
GO:0005506; Molecular function:iron ion binding
GO:0016002; Molecular function:sulfite reductase activity
GO:0070814; Biological process:hydrogen sulfide biosynthetic process
GO:0042597; Cellular component:periplasmic space

Cross-references [?]

PROSITE PS51008; MULTIHEME_CYTC; 2;
Pfam PF14522; Cytochrome_C7; 1;
Pfam PF09699; Paired_CXXCH_1; 1;
General Signal; -; 1;

Features [?]

From: MCCA_WOLSU (Q7MSJ8)
Key From To Description Tag Condition FTGroup
BINDING 159 159 /ligand="heme c"
/ligand_id="ChEBI:CHEBI:61717"
/ligand_label="1"
/ligand_part="Fe"
/ligand_part_id="ChEBI:CHEBI:18248"
/note="axial binding residue"		 H
BINDING 171 171 /ligand="heme c"
/ligand_id="ChEBI:CHEBI:61717"
/ligand_label="4"
/ligand_part="Fe"
/ligand_part_id="ChEBI:CHEBI:18248"
/note="axial binding residue"		 H
BINDING 318 318 /ligand="heme c"
/ligand_id="ChEBI:CHEBI:61717"
/ligand_label="2"
/ligand_part="Fe"
/ligand_part_id="ChEBI:CHEBI:18248"
/note="axial binding residue"		 H
BINDING 355 355 /ligand="heme c"
/ligand_id="ChEBI:CHEBI:61717"
/ligand_label="3"
/ligand_part="Fe"
/ligand_part_id="ChEBI:CHEBI:18248"
/note="axial binding residue"		 H
BINDING 360 360 /ligand="heme c"
/ligand_id="ChEBI:CHEBI:61717"
/ligand_label="1"
/ligand_part="Fe"
/ligand_part_id="ChEBI:CHEBI:18248"
/note="axial binding residue"		 H
BINDING 376 376 /ligand="heme c"
/ligand_id="ChEBI:CHEBI:61717"
/ligand_label="4"
/ligand_part="Fe"
/ligand_part_id="ChEBI:CHEBI:18248"
/note="axial binding residue"		 H
BINDING 411 411 /ligand="Cu(+)"
/ligand_id="ChEBI:CHEBI:49552"		 C
BINDING 423 423 /ligand="heme c"
/ligand_id="ChEBI:CHEBI:61717"
/ligand_label="6"
/ligand_part="Fe"
/ligand_part_id="ChEBI:CHEBI:18248"
/note="axial binding residue"		 H
BINDING 434 434 /ligand="heme c"
/ligand_id="ChEBI:CHEBI:61717"
/ligand_label="5"
/ligand_part="Fe"
/ligand_part_id="ChEBI:CHEBI:18248"
/note="axial binding residue"		 H
BINDING 437 437 /ligand="heme c"
/ligand_id="ChEBI:CHEBI:61717"
/ligand_label="3"
/ligand_part="Fe"
/ligand_part_id="ChEBI:CHEBI:18248"
/note="axial binding residue"		 H
BINDING 478 478 /ligand="heme c"
/ligand_id="ChEBI:CHEBI:61717"
/ligand_label="6"
/ligand_part="Fe"
/ligand_part_id="ChEBI:CHEBI:18248"
/note="axial binding residue"		 H
BINDING 491 491 /ligand="heme c"
/ligand_id="ChEBI:CHEBI:61717"
/ligand_label="8"
/ligand_part="Fe"
/ligand_part_id="ChEBI:CHEBI:18248"
/note="axial binding residue"		 H
BINDING 500 500 /ligand="heme c"
/ligand_id="ChEBI:CHEBI:61717"
/ligand_label="7"
/ligand_part="Fe"
/ligand_part_id="ChEBI:CHEBI:18248"
/note="axial binding residue"		 H
BINDING 507 507 /ligand="Cu(+)"
/ligand_id="ChEBI:CHEBI:49552"		 C
BINDING 528 528 /ligand="heme c"
/ligand_id="ChEBI:CHEBI:61717"
/ligand_label="5"
/ligand_part="Fe"
/ligand_part_id="ChEBI:CHEBI:18248"
/note="axial binding residue"		 H
BINDING 591 591 /ligand="heme c"
/ligand_id="ChEBI:CHEBI:61717"
/ligand_label="8"
/ligand_part="Fe"
/ligand_part_id="ChEBI:CHEBI:18248"
/note="axial binding residue"		 H
BINDING 675 675 /ligand="heme c"
/ligand_id="ChEBI:CHEBI:61717"
/ligand_label="7"
/ligand_part="Fe"
/ligand_part_id="ChEBI:CHEBI:18248"
/note="axial binding residue"		 H
BINDING 155 155 /ligand="heme c"
/ligand_id="ChEBI:CHEBI:61717"
/ligand_label="1"
/note="covalent"		 C
BINDING 158 158 /ligand="heme c"
/ligand_id="ChEBI:CHEBI:61717"
/ligand_label="1"
/note="covalent"		 C
BINDING 220 220 /ligand="substrate" K
BINDING 297 297 /ligand="substrate" Y
BINDING 314 314 /ligand="heme c"
/ligand_id="ChEBI:CHEBI:61717"
/ligand_label="2"
/note="covalent"		 C
BINDING 317 317 /ligand="heme c"
/ligand_id="ChEBI:CHEBI:61717"
/ligand_label="2"
/note="covalent"		 C
BINDING 351 351 /ligand="heme c"
/ligand_id="ChEBI:CHEBI:61717"
/ligand_label="3"
/note="covalent"		 C
BINDING 354 354 /ligand="heme c"
/ligand_id="ChEBI:CHEBI:61717"
/ligand_label="3"
/note="covalent"		 C
BINDING 372 372 /ligand="heme c"
/ligand_id="ChEBI:CHEBI:61717"
/ligand_label="4"
/note="covalent"		 C
BINDING 375 375 /ligand="heme c"
/ligand_id="ChEBI:CHEBI:61717"
/ligand_label="4"
/note="covalent"		 C
BINDING 378 378 /ligand="substrate" R
BINDING 430 430 /ligand="heme c"
/ligand_id="ChEBI:CHEBI:61717"
/ligand_label="5"
/note="covalent"		 C
BINDING 433 433 /ligand="heme c"
/ligand_id="ChEBI:CHEBI:61717"
/ligand_label="5"
/note="covalent"		 C
BINDING 474 474 /ligand="heme c"
/ligand_id="ChEBI:CHEBI:61717"
/ligand_label="6"
/note="covalent"		 C
BINDING 477 477 /ligand="heme c"
/ligand_id="ChEBI:CHEBI:61717"
/ligand_label="6"
/note="covalent"		 C
BINDING 496 496 /ligand="heme c"
/ligand_id="ChEBI:CHEBI:61717"
/ligand_label="7"
/note="covalent"		 C
BINDING 499 499 /ligand="heme c"
/ligand_id="ChEBI:CHEBI:61717"
/ligand_label="7"
/note="covalent"		 C
BINDING 574 574 /ligand="heme c"
/ligand_id="ChEBI:CHEBI:61717"
/ligand_label="8"
/note="covalent"		 C
BINDING 590 590 /ligand="heme c"
/ligand_id="ChEBI:CHEBI:61717"
/ligand_label="8"
/note="covalent"		 C

Additional information [?]

Size range 640-710 amino acids
Related rules None
Fusion Nter: None Cter: None



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