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Annotation rule MF_02058
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General rule information [?]

Accession MF_02058
Dates 11-MAR-2016 (Created)
20-NOV-2019 (Last updated, Version 4)
Name Choline_CutC
Scope
Bacteria; Coriobacteriales
Bacteria; Firmicutes
Bacteria; Proteobacteria
Template Q30W70 (CUTC_DESAG)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
CUTC
Protein name
RecName: Full=Choline trimethylamine-lyase;
Short=Choline TMA-lyase;
EC 4.3.99.4;
AltName: Full=Choline utilization protein C;
Gene name
cutC

Comments [?]

Function Glycine radical enzyme that catalyzes the cleavage of a C-N bond in choline, producing trimethylamine (TMA) and acetaldehyde.
Catalytic activity RHEA:35095: choline = acetaldehyde + trimethylamine
EC 4.3.99.4
Pathway Amine and polyamine metabolism; choline degradation.
Ptm Requires the activating protein CutD to generate the key active site glycyl radical on #{Gly-821} that is involved in catalysis.
Similarity Belongs to the glycyl radical enzyme (GRE) family. CutC subfamily.

Keywords [?]


Gene Ontology [?]

GO:0016840; Molecular function: carbon-nitrogen lyase activity.
GO:0042426; Biological process: choline catabolic process.

Cross-references [?]

PROSITE PS00850; GLY_RADICAL_1; 1;
PS51149; GLY_RADICAL_2; 1; trigger=PRU00493;
PS51554; PFL; 1; trigger=PRU00887;
Pfam PF01228; Gly_radical; 1;
PF02901; PFL-like; 1;
TIGRFAMs TIGR04394; choline_CutC; 1;

Features [?]

From: CUTC_DESAG (Q30W70)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     489     489       Cysteine radical intermediate     C  
ACT_SITE     491     491       Proton acceptor     E  
MOD_RES     821     821       Glycine radical     G  

Additional information [?]

Size range 785-1200 amino acids
Related rules None
Fusion None