HAMAP logo

HAMAP rule MF_02084

Send feedback

General rule information [?]

Accession MF_02084
Dates 5-JAN-2017 (Created)
1-JUN-2023 (Last updated, Version 12)
Name LysJ_aminotrans_3
Scope
Archaea
Bacteria; Chloroflexota
Bacteria; Deinococcota
Templates Q4JAP8 (LYSJ_SULAC); Q93R93 (LYSJ_THET2); Q5SHH5 (LYSJ_THET8): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
LYSJ
case <OC:Sulfolobales>
Protein name
RecName: Full=[LysW]-aminoadipate semialdehyde/glutamate semialdehyde transaminase;
EC 2.6.1.118;
EC 2.6.1.124;
else case <OC:Archaea> and not <OC:Sulfolobales>
Protein name
RecName: Full=Putative [LysW]-aminoadipate semialdehyde/glutamate semialdehyde transaminase;
EC 2.6.1.118;
EC 2.6.1.124;
else case <OC:Deinococcota>
Protein name
RecName: Full=[LysW]-aminoadipate semialdehyde transaminase;
EC 2.6.1.118;
else case <OC:Chloroflexota>
Protein name
RecName: Full=Putative [LysW]-aminoadipate semialdehyde transaminase;
EC 2.6.1.118;
end case
Gene name
lysJ

Comments [?]

case <OC:Archaea>
Function Involved in both the arginine and lysine biosynthetic pathways.
else case <OC:Bacteria>
Function Catalyzes the transfer of the amino group of L-glutamate to [LysW]-aminoadipate 6-semialdehyde, generating [LysW]-gamma-L-lysine.
end case
Catalytic activity RHEA:41952: 2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + L-glutamate
EC 2.6.1.118
case <OC:Archaea>
Catalytic activity RHEA:52672: 2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate = [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + L-glutamate
EC 2.6.1.124
end case
Cofactor pyridoxal 5'-phosphate
Note: Binds 1 pyridoxal phosphate per subunit
Pathway Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 4/5.
case <OC:Archaea>
Pathway Amino-acid biosynthesis; L-arginine biosynthesis.
end case
Subunit Homodimer.
Subcellular location Cytoplasm.
Similarity Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily.

Keywords [?]

Amino-acid biosynthesis
Aminotransferase
case <OC:Archaea>
Arginine biosynthesis
end case
Cytoplasm
Lysine biosynthesis
Pyridoxal phosphate
Transferase

Gene Ontology [?]

GO:0008483; Molecular function: transaminase activity.
case <OC:Archaea>
GO:0042450; Biological process: arginine biosynthetic process via ornithine.
end case
GO:0019878; Biological process: lysine biosynthetic process via aminoadipic acid.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

PROSITE PS00600; AA_TRANSFER_CLASS_3; 1;
Pfam PF00202; Aminotran_3; 1;
NCBIfam TIGR00707; argD; 1;

Features [?]

From: LYSJ_THET8 (Q5SHH5)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING (Optional)     113     114       /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326     G-[TA]  
BINDING (Optional)     225     228       /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326     D-E-[IV]-Q  
BINDING (Optional)     140     140       /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326     F  
BINDING (Optional)     143     143       /ligand="substrate     R  
BINDING (Optional)     282     282       /ligand="substrate     [ST]  
BINDING (Optional)     283     283       /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326     T  
MOD_RES     254     254       N6-(pyridoxal phosphate)lysine     K  

Additional information [?]

Size range 360-450 amino acids
Related rules None
Fusion None


View rule in raw text format (no links)