HAMAP rule MF_02084
General rule information
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Accession | MF_02084 |
Dates | 5-JAN-2017 (Created) 1-JUN-2023 (Last updated, Version 12) |
Name | LysJ_aminotrans_3 |
Scope | Archaea
Bacteria; Chloroflexota
Bacteria; Deinococcota |
Templates | Q4JAP8 (LYSJ_SULAC); Q93R93 (LYSJ_THET2); Q5SHH5 (LYSJ_THET8): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
|
case <OC:Sulfolobales>
Protein name |
|
else case <OC:Archaea> and not <OC:Sulfolobales>
Protein name |
|
else case <OC:Deinococcota>
Protein name |
|
else case <OC:Chloroflexota>
Protein name |
|
end case
Gene name |
|
Comments
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case <OC:Archaea>
Function | Involved in both the arginine and lysine biosynthetic pathways. |
else case <OC:Bacteria>
Function | Catalyzes the transfer of the amino group of L-glutamate to [LysW]-aminoadipate 6-semialdehyde, generating [LysW]-gamma-L-lysine. |
end case
Catalytic activity | RHEA:41952: 2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + L-glutamate
EC 2.6.1.118 |
case <OC:Archaea>
Catalytic activity | RHEA:52672: 2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate = [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + L-glutamate
EC 2.6.1.124 |
end case
Cofactor | pyridoxal 5'-phosphate Note: Binds 1 pyridoxal phosphate per subunit |
Pathway | Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 4/5. |
case <OC:Archaea>
Pathway | Amino-acid biosynthesis; L-arginine biosynthesis. |
end case
Subunit | Homodimer. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily. |
Keywords
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case <OC:Archaea>
end case
Gene Ontology
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GO:0008483; Molecular function: transaminase activity.
case <OC:Archaea>
GO:0042450; Biological process: arginine biosynthetic process via ornithine.
end case
GO:0019878; Biological process: lysine biosynthetic process via aminoadipic acid.
GO:0005737; Cellular component: cytoplasm.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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Features
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From: LYSJ_THET8 (Q5SHH5) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING (Optional) | 113 | 114 | /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326 | G-[TA] | ||||||||
BINDING (Optional) | 225 | 228 | /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326 | D-E-[IV]-Q | ||||||||
BINDING (Optional) | 140 | 140 | /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326 | F | ||||||||
BINDING (Optional) | 143 | 143 | /ligand="substrate | R | ||||||||
BINDING (Optional) | 282 | 282 | /ligand="substrate | [ST] | ||||||||
BINDING (Optional) | 283 | 283 | /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326 | T | ||||||||
MOD_RES | 254 | 254 | N6-(pyridoxal phosphate)lysine | K |
Additional information
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Size range | 360-450 amino acids |
Related rules | None |
Fusion | None |