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Annotation rule MF_02084 |
General rule information
[?]
Accession |
MF_02084 |
Dates |
5-JAN-2017 (Created) 27-APR-2020 (Last updated, Version 6) |
Scope |
Archaea
Bacteria; Chloroflexi
Bacteria; Deinococcus-Thermus |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
case <OC:Sulfolobales>
else case <OC:Archaea> and not <OC:Sulfolobales>
Protein name |
RecName:
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Full=Putative [LysW]-aminoadipate semialdehyde/glutamate semialdehyde transaminase;
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EC 2.6.1.-;
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EC 2.6.1.118;
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else case <OC:Deinococcus-Thermus>
Protein name |
RecName:
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Full=[LysW]-aminoadipate semialdehyde transaminase;
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EC 2.6.1.118;
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else case <OC:Chloroflexi>
Protein name |
RecName:
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Full=Putative [LysW]-aminoadipate semialdehyde transaminase;
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EC 2.6.1.118;
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end case
case <OC:Archaea>
Function |
Involved in both the arginine and lysine biosynthetic pathways. |
else case <OC:Bacteria>
Function |
Catalyzes the transfer of the amino group of L-glutamate to [LysW]-aminoadipate 6-semialdehyde, generating [LysW]-gamma-L-lysine. |
end case
Catalytic activity |
RHEA:41952: 2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + L-glutamate
EC 2.6.1.118
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case <OC:Archaea>
Catalytic activity |
RHEA:52672: 2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate = [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + L-glutamate
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end case
Cofactor |
pyridoxal 5'-phosphate Note: Binds 1 pyridoxal phosphate per subunit |
Pathway |
Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 4/5. |
case <OC:Archaea>
Pathway |
Amino-acid biosynthesis; L-arginine biosynthesis. |
end case
Subunit |
Homodimer. |
Subcellular location |
Cytoplasm. |
Similarity |
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily. |
case <OC:Archaea>
end case
GO:0008483; Molecular function: transaminase activity.
case <OC:Archaea>
GO:0042450; Biological process: arginine biosynthetic process via ornithine.
end case
GO:0019878; Biological process: lysine biosynthetic process via aminoadipic acid.
GO:0005737; Cellular component: cytoplasm.
From: LYSJ_THET8 (Q5SHH5) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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REGION (Optional)
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113
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114
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Pyridoxal phosphate binding
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G-[TA]
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REGION (Optional)
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225
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228
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Pyridoxal phosphate binding
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D-E-[IV]-Q
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BINDING (Optional)
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140
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140
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Pyridoxal phosphate; via carbonyl oxygen
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F
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BINDING (Optional)
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143
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143
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Substrate
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R
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BINDING (Optional)
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282
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282
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Substrate
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[ST]
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BINDING (Optional)
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283
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283
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Pyridoxal phosphate
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T
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MOD_RES
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254
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254
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N6-(pyridoxal phosphate)lysine
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K
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Additional information
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Size range |
360-450 amino acids |
Related rules |
None |
Fusion |
None |