HAMAP rule MF_02094
General rule information
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| Accession | MF_02094 |
| Dates | 10-OCT-2017 (Created)
1-JUN-2023 (Last updated, Version 6) |
| Name | Edd |
| Scope(s) |
Bacteria |
| Template(s) | P0ADF6 (EDD_ECOLI); P21909 (EDD_ZYMMO); [ Recover all ] |
| Triggered by |
HAMAP; MF_02094 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | EDD |
| Protein name | RecName: Full=Phosphogluconate dehydratase; EC=4.2.1.12; |
| Gene name | Name=edd; |
Comments
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| FUNCTION | Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate. |
| CATALYTIC ACTIVITY | Reaction=6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D- gluconate + H2O; Xref=Rhea:RHEA:17277, ChEBI:CHEBI:15377, ChEBI:CHEBI:57569, ChEBI:CHEBI:58759; EC=4.2.1.12; |
| COFACTOR | Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 1 [4Fe-4S] cluster |
| PATHWAY | Carbohydrate metabolism; Entner-Doudoroff pathway. |
| SIMILARITY | Belongs to the IlvD/Edd family. |
Keywords
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Gene Ontology
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| GO:0004456; Molecular function:phosphogluconate dehydratase activity |
| GO:0051539; Molecular function:4 iron, 4 sulfur cluster binding |
| GO:0046177; Biological process:D-gluconate catabolic process |
| GO:0009255; Biological process:Entner-Doudoroff pathway through 6-phosphogluconate |
Cross-references
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| PROSITE | PS00886; ILVD_EDD_1; 1; |
| PROSITE | PS00887; ILVD_EDD_2; 1; |
| Pfam | PF00920; ILVD_EDD; 1; |
| NCBIfam | TIGR01196; edd; 1; |
Features
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| From: EDD_ECOLI (P0ADF6) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 154 | 154 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" |
C | ||||||||
| BINDING | 221 | 221 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" |
C | ||||||||
Additional information
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| Size range | 570-660 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |