HAMAP rule MF_02102
General rule information
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Accession | MF_02102 |
Dates | 7-JUL-2009 (Created) 1-JUN-2023 (Last updated, Version 15) |
Name | PTCase |
Scope | Bacteria; Bacillota
Bacteria; Mycoplasmatota |
Templates | Q837U7 (PTC_ENTFA); Q8DW19 (PTC_STRMU): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the phosphorolysis of N-carbamoylputrescine to form carbamoyl phosphate and putrescine. Is involved in the degradation pathway of the polyamine agmatine. |
Catalytic activity | RHEA:21936: carbamoyl phosphate + putrescine = H(+) + N-carbamoylputrescine + phosphate
EC 2.1.3.6 |
Pathway | Amine and polyamine biosynthesis; putrescine biosynthesis via agmatine pathway; putrescine from N-carbamoylputrescine (transferase route): step 1/1. |
Subunit | Homotrimer. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the aspartate/ornithine carbamoyltransferase superfamily. PTCase family. |
Keywords
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Gene Ontology
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GO:0050231; Molecular function: putrescine carbamoyltransferase activity.
GO:0033390; Biological process: putrescine biosynthetic process from arginine via N-carbamoylputrescine.
GO:0033390; Biological process: putrescine biosynthetic process from arginine via N-carbamoylputrescine.
Cross-references
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PROSITE | PS00097; CARBAMOYLTRANSFERASE; 1; |
Pfam | PF00185; OTCace; 1; |
PF02729; OTCace_N; 1; | |
PRINTS | PR00100; AOTCASE; 1; |
PR00102; OTCASE; 1; | |
NCBIfam | TIGR00658; Orni_carb_tr; 1; |
Features
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From: PTC_ENTFA (Q837U7) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 52 | 56 | /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228 | S-T-R-T-R | ||||||||
BINDING | 268 | 271 | /ligand="putrescine" /ligand_id="ChEBI:CHEBI:326268 | H-C-L-P | ||||||||
BINDING | 103 | 103 | /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228 | R | ||||||||
BINDING | 130 | 130 | /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228 | H | ||||||||
SITE | 27 | 27 | Important for structural integrity | K | ||||||||
SITE | 143 | 143 | Important for structural integrity | E |
Additional information
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Size range | 339-365 amino acids |
Related rules | MF_01109 (OTCC) |
Fusion | None |