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HAMAP rule MF_02102

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General rule information [?]

Accession MF_02102
Dates 7-JUL-2009 (Created)
1-JUN-2023 (Last updated, Version 15)
Name PTCase
Scope(s) Bacteria
Bacillota
Mycoplasmatota
Template(s) Q837U7 (PTC_ENTFA); Q8DW19 (PTC_STRMU); [ Recover all ]
Triggered by HAMAP; MF_02102 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PTC
Protein name RecName: Full=Putrescine carbamoyltransferase;
                 Short=PTC;
                 Short=PTCase;
                 EC=2.1.3.6;
AltName: Full=Putrescine transcarbamoylase;
AltName: Full=Putrescine transcarbamylase;
Gene name Name=ptcA;

Comments [?]

FUNCTIONCatalyzes the phosphorolysis of N-carbamoylputrescine to form carbamoyl phosphate and putrescine. Is involved in the degradation pathway of the polyamine agmatine.
CATALYTIC ACTIVITY Reaction=carbamoyl phosphate + putrescine = H(+) + N- carbamoylputrescine + phosphate; Xref=Rhea:RHEA:21936, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58228, ChEBI:CHEBI:58318, ChEBI:CHEBI:326268; EC=2.1.3.6;
PATHWAYAmine and polyamine biosynthesis; putrescine biosynthesis via agmatine pathway; putrescine from N-carbamoylputrescine (transferase route): step 1/1.
SUBUNITHomotrimer.
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the aspartate/ornithine carbamoyltransferase superfamily. PTCase family.

Keywords [?]


Gene Ontology [?]

GO:0050231; Molecular function:putrescine carbamoyltransferase activity
GO:0033390; Biological process:putrescine biosynthetic process from arginine via N-carbamoylputrescine

Cross-references [?]

PROSITE PS00097; CARBAMOYLTRANSFERASE; 1;
Pfam PF00185; OTCace; 1;
Pfam PF02729; OTCace_N; 1;
PRINTS PR00100; AOTCASE; 1;
PRINTS PR00102; OTCASE; 1;
NCBIfam TIGR00658; Orni_carb_tr; 1;

Features [?]

From: PTC_ENTFA (Q837U7)
Key From To Description Tag Condition FTGroup
BINDING 52 56 /ligand="carbamoyl phosphate"
/ligand_id="ChEBI:CHEBI:58228"
S-T-R-T-R
BINDING 268 271 /ligand="putrescine"
/ligand_id="ChEBI:CHEBI:326268"
H-C-L-P
BINDING 103 103 /ligand="carbamoyl phosphate"
/ligand_id="ChEBI:CHEBI:58228"
R
BINDING 130 130 /ligand="carbamoyl phosphate"
/ligand_id="ChEBI:CHEBI:58228"
H
SITE 27 27 /note="Important for structural integrity" K
SITE 143 143 /note="Important for structural integrity" E

Additional information [?]

Size range 339-365 amino acids
Related rules MF_01109
Fusion Nter: None Cter: None



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