HAMAP rule MF_02102

General rule information [?]

Accession	MF_02102
Dates	7-JUL-2009 (Created) 1-JUN-2023 (Last updated, Version 15)

Name

PTCase

Scope

Bacteria; Bacillota

Bacteria; Mycoplasmatota

Templates

Q837U7 (PTC_ENTFA); Q8DW19 (PTC_STRMU): [Recover all]

Triggered by

HAMAP; MF_02102 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

PTC

Protein name

RecName:		Full=Putrescine carbamoyltransferase;
		Short=PTC;
		Short=PTCase;
		EC 2.1.3.6;
AltName:		Full=Putrescine transcarbamoylase;
AltName:		Full=Putrescine transcarbamylase;

Gene name

ptcA

Comments [?]

Function	Catalyzes the phosphorolysis of N-carbamoylputrescine to form carbamoyl phosphate and putrescine. Is involved in the degradation pathway of the polyamine agmatine.
Catalytic activity	RHEA:21936: carbamoyl phosphate + putrescine = H(+) + N-carbamoylputrescine + phosphate EC 2.1.3.6
Pathway	Amine and polyamine biosynthesis; putrescine biosynthesis via agmatine pathway; putrescine from N-carbamoylputrescine (transferase route): step 1/1.
Subunit	Homotrimer.
Subcellular location	Cytoplasm.
Similarity	Belongs to the aspartate/ornithine carbamoyltransferase superfamily. PTCase family.

Keywords [?]

Cytoplasm
Polyamine biosynthesis
Transferase

Gene Ontology [?]

GO:0050231; Molecular function: putrescine carbamoyltransferase activity.
GO:0033390; Biological process: putrescine biosynthetic process from arginine via N-carbamoylputrescine.

Cross-references [?]

PROSITE	PS00097; CARBAMOYLTRANSFERASE; 1;
Pfam	PF00185; OTCace; 1;
	PF02729; OTCace_N; 1;
PRINTS	PR00100; AOTCASE; 1;
	PR00102; OTCASE; 1;
NCBIfam	TIGR00658; Orni_carb_tr; 1;

Features [?]

From: PTC_ENTFA (Q837U7)

Key From To Description Tag Condition FTGroup

BINDING 52 56 /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228 S-T-R-T-R

BINDING 268 271 /ligand="putrescine" /ligand_id="ChEBI:CHEBI:326268 H-C-L-P

BINDING 103 103 /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228 R

BINDING 130 130 /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228 H

SITE 27 27 Important for structural integrity K

SITE 143 143 Important for structural integrity E

Additional information [?]

Size range	339-365 amino acids
Related rules	MF_01109 (OTCC)
Fusion	None

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