HAMAP rule MF_02102
General rule information
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| Accession | MF_02102 |
| Dates | 7-JUL-2009 (Created)
2-SEP-2024 (Last updated, Version 16) |
| Name | PTCase |
| Scope(s) |
Bacteria Bacillota Mycoplasmatota |
| Template(s) | Q837U7 (PTC_ENTFA); Q8DW19 (PTC_STRMU); [ Recover all ] |
| Triggered by |
HAMAP; MF_02102 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | PTC |
| Protein name | RecName: Full=Putrescine carbamoyltransferase; Short=PTC; Short=PTCase; EC=2.1.3.6; AltName: Full=Putrescine transcarbamoylase; AltName: Full=Putrescine transcarbamylase; |
| Gene name | Name=ptcA; |
Comments
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| FUNCTION | Catalyzes the phosphorolysis of N-carbamoylputrescine to form carbamoyl phosphate and putrescine. Is involved in the degradation pathway of the polyamine agmatine. |
| CATALYTIC ACTIVITY | Reaction=carbamoyl phosphate + putrescine = N-carbamoylputrescine + phosphate + H(+); Xref=Rhea:RHEA:21936, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58228, ChEBI:CHEBI:58318, ChEBI:CHEBI:326268; EC=2.1.3.6; |
| PATHWAY | Amine and polyamine biosynthesis; putrescine biosynthesis via agmatine pathway; putrescine from N-carbamoylputrescine (transferase route): step 1/1. |
| SUBUNIT | Homotrimer. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the aspartate/ornithine carbamoyltransferase superfamily. PTCase family. |
Keywords
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Gene Ontology
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| GO:0050231; Molecular function:putrescine carbamoyltransferase activity |
| GO:0033390; Biological process:putrescine biosynthetic process from arginine via N-carbamoylputrescine |
Cross-references
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| PROSITE | PS00097; CARBAMOYLTRANSFERASE; 1; |
| Pfam | PF00185; OTCace; 1; |
| Pfam | PF02729; OTCace_N; 1; |
| PRINTS | PR00100; AOTCASE; 1; |
| PRINTS | PR00102; OTCASE; 1; |
| NCBIfam | TIGR00658; Orni_carb_tr; 1; |
Features
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| From: PTC_ENTFA (Q837U7) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 52 | 56 | /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228" |
S-T-R-T-R | ||||||||
| BINDING | 268 | 271 | /ligand="putrescine" /ligand_id="ChEBI:CHEBI:326268" |
H-C-L-P | ||||||||
| BINDING | 103 | 103 | /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228" |
R | ||||||||
| BINDING | 130 | 130 | /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228" |
H | ||||||||
| SITE | 27 | 27 | /note="Important for structural integrity" | K | ||||||||
| SITE | 143 | 143 | /note="Important for structural integrity" | E | ||||||||
Additional information
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| Size range | 339-365 amino acids |
| Related rules |
MF_01109 |
| Fusion | Nter: None Cter: None |