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Annotation rule MF_02102
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General rule information [?]

Accession MF_02102
Dates 7-JUL-2009 (Created)
13-JAN-2023 (Last updated, Version 13)
Name PTCase
Scope
Bacteria; Bacillota
Bacteria; Tenericutes
Templates Q837U7 (PTC_ENTFA); Q8DW19 (PTC_STRMU): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PTC
Protein name
RecName: Full=Putrescine carbamoyltransferase;
Short=PTC;
Short=PTCase;
EC 2.1.3.6;
AltName: Full=Putrescine transcarbamoylase;
AltName: Full=Putrescine transcarbamylase;
Gene name
ptcA

Comments [?]

Function Catalyzes the phosphorolysis of N-carbamoylputrescine to form carbamoyl phosphate and putrescine. Is involved in the degradation pathway of the polyamine agmatine.
Catalytic activity RHEA:21936: carbamoyl phosphate + putrescine = H(+) + N-carbamoylputrescine + phosphate
EC 2.1.3.6
Pathway Amine and polyamine biosynthesis; putrescine biosynthesis via agmatine pathway; putrescine from N-carbamoylputrescine (transferase route): step 1/1.
Subunit Homotrimer.
Subcellular location Cytoplasm.
Similarity Belongs to the aspartate/ornithine carbamoyltransferase superfamily. PTCase family.

Keywords [?]

Cytoplasm
Polyamine biosynthesis
Transferase

Gene Ontology [?]

GO:0050231; Molecular function: putrescine carbamoyltransferase activity.
GO:0033390; Biological process: putrescine biosynthetic process from arginine via N-carbamoylputrescine.

Cross-references [?]

PROSITE PS00097; CARBAMOYLTRANSFERASE; 1;
Pfam PF00185; OTCace; 1;
PF02729; OTCace_N; 1;
PRINTS PR00100; AOTCASE; 1;
PR00102; OTCASE; 1;
TIGRFAMs TIGR00658; Orni_carb_tr; 1;

Features [?]

From: PTC_ENTFA (Q837U7)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     52     56       /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228     S-T-R-T-R  
BINDING     268     271       /ligand="putrescine" /ligand_id="ChEBI:CHEBI:326268     H-C-L-P  
BINDING     103     103       /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228     R  
BINDING     130     130       /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228     H  
SITE     27     27       Important for structural integrity     K  
SITE     143     143       Important for structural integrity     E  

Additional information [?]

Size range 339-365 amino acids
Related rules MF_01109 (OTCC)
Fusion None


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