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HAMAP rule MF_02212
General rule information
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| Accession | MF_02212 |
| Dates | 4-MAR-2019 (Created)
1-JUN-2023 (Last updated, Version 5) |
| Name | Bsr_racemase |
| Scope(s) |
Bacteria |
| Template(s) | I6LNY0 (BSR_PSEPU); A0KLG5 (BSR_AERHH); Q88GJ9 (BSR_PSEPK); I0J1I6 (BSR_PSETA); Q9KSE5 (BSR_VIBCH); [ Recover all ] |
| Triggered by |
HAMAP; MF_02212 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | BSR |
| Protein name | RecName: Full=Broad specificity amino-acid racemase; EC=5.1.1.10; Flags: Precursor; |
Comments
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| FUNCTION | Amino-acid racemase able to utilize a broad range of substrates. |
| CATALYTIC ACTIVITY | Reaction=an L-alpha-amino acid = a D-alpha-amino acid; Xref=Rhea:RHEA:18317, ChEBI:CHEBI:59869, ChEBI:CHEBI:59871; EC=5.1.1.10; |
| CATALYTIC ACTIVITY | Reaction=L-lysine = D-lysine; Xref=Rhea:RHEA:22864, ChEBI:CHEBI:32551, ChEBI:CHEBI:32557; |
| CATALYTIC ACTIVITY | Reaction=L-arginine = D-arginine; Xref=Rhea:RHEA:18069, ChEBI:CHEBI:32682, ChEBI:CHEBI:32689; |
| COFACTOR | Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; |
| SUBCELLULAR LOCATION | Periplasm. |
| SIMILARITY | Belongs to the alanine racemase family. Bsr subfamily. |
Keywords
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| Isomerase | |
| Periplasm | |
| Pyridoxal phosphate | |
| Signal | |
| case <FTTag:Disulfide> | |
| Disulfide bond | |
| end case | |
Gene Ontology
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| GO:0047661; Molecular function:amino-acid racemase activity |
| GO:0030170; Molecular function:pyridoxal phosphate binding |
| GO:0042597; Cellular component:periplasmic space |
Cross-references
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| Pfam | PF00842; Ala_racemase_C; 1; |
| Pfam | PF01168; Ala_racemase_N; 1; |
| PRINTS | PR00992; ALARACEMASE; 1; |
| NCBIfam | TIGR00492; alr; 1; |
| PROSITE | PS00395; ALANINE_RACEMASE; 1; |
| General | Signal; -; 1; |
Features
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| From: BSR_PSEPU (I6LNY0) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 75 | 75 | /note="Proton acceptor" | K | ||||||||
| ACT_SITE | 301 | 301 | /note="Proton acceptor" | Y | ||||||||
| BINDING | 174 | 174 | /ligand="substrate" | R | ||||||||
| BINDING | 349 | 349 | /ligand="substrate" | M | ||||||||
| MOD_RES | 75 | 75 | /note="N6-(pyridoxal phosphate)lysine" | K | ||||||||
| DISULFID | 71 | 97 | Disulfide | C-x*-C | ||||||||
Additional information
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| Size range | 380-445 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |