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Annotation rule MF_02222
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General rule information [?]

Accession MF_02222
Dates 6-AUG-2019 (Created)
20-NOV-2019 (Last updated, Version 2)
Name Homocitr_synth_fung_arch
Scope
Bacteria
Archaea
Templates O87198 (HOSA_THET2); Q4J989 (HOSA_SULAC); Q971S5 (HOSA_SULTO): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
HOSA
Protein name
RecName: Full=Homocitrate synthase;
Short=HCS;
EC 2.3.3.14;

Comments [?]

Function Catalyzes the aldol-type condensation of 2-oxoglutarate with acetyl-CoA to yield homocitrate. Carries out the first step of the alpha-aminoadipate (AAA) lysine biosynthesis pathway.
Catalytic activity RHEA:12929: 2-oxoglutarate + acetyl-CoA + H2O = (2R)-homocitrate + CoA + H(+)
EC 2.3.3.14
PhysiologicalDirection=left-to-right (RHEA:12930)
Cofactor Mg(2+)
Mn(2+)
Pathway Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 1/5.
Similarity Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.

Keywords [?]


Gene Ontology [?]

GO:0004410; Molecular function: homocitrate synthase activity.
GO:0019878; Biological process: lysine biosynthetic process via aminoadipic acid.

Cross-references [?]

PROSITE PS00815; AIPM_HOMOCIT_SYNTH_1; 1;
PS00816; AIPM_HOMOCIT_SYNTH_2; 1;
PS50991; PYR_CT; 1; trigger=PRU01151;
Pfam PF00682; HMGL-like; 1;
TIGRFAMs TIGR02146; LysS_fung_arch; 1;

Features [?]

From: HOSA_THET2 (O87198)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     292     292       Proton acceptor     H  
METAL     13     13       Magnesium     E  
METAL     195     195       Magnesium; via tele nitrogen     H  
METAL     197     197       Magnesium; via tele nitrogen     H  
BINDING     12     12       2-oxoglutarate     R  
BINDING     72     72       2-oxoglutarate     H  
BINDING     133     133       2-oxoglutarate     R  
BINDING     166     166       2-oxoglutarate     T  

Additional information [?]

Size range 340-500 amino acids
Related rules None
Fusion None