HAMAP rule MF_02222
General rule information
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| Accession | MF_02222 |
| Dates | 6-AUG-2019 (Created)
1-JUN-2023 (Last updated, Version 5) |
| Name | Homocitr_synth_fung_arch |
| Scope(s) |
Bacteria Archaea |
| Template(s) | O87198 (HOSA_THET2); Q4J989 (HOSA_SULAC); Q971S5 (HOSA_SULTO); [ Recover all ] |
| Triggered by |
HAMAP; MF_02222 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | HOSA |
| Protein name | RecName: Full=Homocitrate synthase; Short=HCS; EC=2.3.3.14; |
Comments
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| FUNCTION | Catalyzes the aldol-type condensation of 2-oxoglutarate with acetyl-CoA to yield homocitrate. Carries out the first step of the alpha-aminoadipate (AAA) lysine biosynthesis pathway. |
| CATALYTIC ACTIVITY | Reaction=2-oxoglutarate + acetyl-CoA + H2O = (2R)-homocitrate + CoA + H(+); Xref=Rhea:RHEA:12929, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16810, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:58884; EC=2.3.3.14; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12930; |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; |
| PATHWAY | Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 1/5. |
| SIMILARITY | Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily. |
Keywords
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Gene Ontology
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| GO:0004410; Molecular function:homocitrate synthase activity |
| GO:0019878; Biological process:lysine biosynthetic process via aminoadipic acid |
Cross-references
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| PROSITE | PS00815; AIPM_HOMOCIT_SYNTH_1; 1; |
| PROSITE | PS00816; AIPM_HOMOCIT_SYNTH_2; 1; |
| PROSITE | PS50991; PYR_CT; 1; |
| Pfam | PF00682; HMGL-like; 1; |
| NCBIfam | TIGR02146; LysS_fung_arch; 1; |
Features
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| From: HOSA_THET2 (O87198) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 292 | 292 | /note="Proton acceptor" | H | ||||||||
| BINDING | 13 | 13 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
E | ||||||||
| BINDING | 195 | 195 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
H | ||||||||
| BINDING | 197 | 197 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
H | ||||||||
| BINDING | 12 | 12 | /ligand="2-oxoglutarate" /ligand_id="ChEBI:CHEBI:16810" |
R | ||||||||
| BINDING | 72 | 72 | /ligand="2-oxoglutarate" /ligand_id="ChEBI:CHEBI:16810" |
H | ||||||||
| BINDING | 133 | 133 | /ligand="2-oxoglutarate" /ligand_id="ChEBI:CHEBI:16810" |
R | ||||||||
| BINDING | 166 | 166 | /ligand="2-oxoglutarate" /ligand_id="ChEBI:CHEBI:16810" |
T | ||||||||
Additional information
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| Size range | 340-500 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |