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| Annotation rule MF_02222 |
General rule information
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| Accession | MF_02222 |
| Dates | 6-AUG-2019 (Created) 20-NOV-2019 (Last updated, Version 2) |
| Name | Homocitr_synth_fung_arch |
| Scope | Bacteria
Archaea |
| Templates | O87198 (HOSA_THET2); Q4J989 (HOSA_SULAC); Q971S5 (HOSA_SULTO): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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Comments
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| Function | Catalyzes the aldol-type condensation of 2-oxoglutarate with acetyl-CoA to yield homocitrate. Carries out the first step of the alpha-aminoadipate (AAA) lysine biosynthesis pathway. |
| Catalytic activity | RHEA:12929: 2-oxoglutarate + acetyl-CoA + H2O = (2R)-homocitrate + CoA + H(+)
EC 2.3.3.14 PhysiologicalDirection=left-to-right (RHEA:12930) |
| Cofactor | Mg(2+) Mn(2+) |
| Pathway | Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 1/5. |
| Similarity | Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily. |
Keywords
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Gene Ontology
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GO:0004410; Molecular function: homocitrate synthase activity.
GO:0019878; Biological process: lysine biosynthetic process via aminoadipic acid.
GO:0019878; Biological process: lysine biosynthetic process via aminoadipic acid.
Cross-references
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| PROSITE | PS00815; AIPM_HOMOCIT_SYNTH_1; 1; |
| PS00816; AIPM_HOMOCIT_SYNTH_2; 1; | |
| PS50991; PYR_CT; 1; trigger=PRU01151; | |
| Pfam | PF00682; HMGL-like; 1; |
| TIGRFAMs | TIGR02146; LysS_fung_arch; 1; |
Features
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| From: HOSA_THET2 (O87198) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 292 | 292 | Proton acceptor | H | ||||||||
| METAL | 13 | 13 | Magnesium | E | ||||||||
| METAL | 195 | 195 | Magnesium; via tele nitrogen | H | ||||||||
| METAL | 197 | 197 | Magnesium; via tele nitrogen | H | ||||||||
| BINDING | 12 | 12 | 2-oxoglutarate | R | ||||||||
| BINDING | 72 | 72 | 2-oxoglutarate | H | ||||||||
| BINDING | 133 | 133 | 2-oxoglutarate | R | ||||||||
| BINDING | 166 | 166 | 2-oxoglutarate | T | ||||||||
Additional information
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| Size range | 340-500 amino acids |
| Related rules | None |
| Fusion | None |