HAMAP rule MF_02222

General rule information [?]

Accession	MF_02222
Dates	6-AUG-2019 (Created) 1-JUN-2023 (Last updated, Version 5)

Name	Homocitr_synth_fung_arch

Scope

Bacteria

Archaea

Templates

O87198 (HOSA_THET2); Q4J989 (HOSA_SULAC); Q971S5 (HOSA_SULTO): [Recover all]

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

HOSA

Protein name

Comments [?]

Function	Catalyzes the aldol-type condensation of 2-oxoglutarate with acetyl-CoA to yield homocitrate. Carries out the first step of the alpha-aminoadipate (AAA) lysine biosynthesis pathway.
Catalytic activity	RHEA:12929: 2-oxoglutarate + acetyl-CoA + H2O = (2R)-homocitrate + CoA + H(+) EC 2.3.3.14 PhysiologicalDirection=left-to-right (RHEA:12930)
Cofactor	Mg(2+) Mn(2+)
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 1/5.
Similarity	Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0004410; Molecular function: homocitrate synthase activity.
GO:0019878; Biological process: lysine biosynthetic process via aminoadipic acid.

Cross-references [?]

Features [?]

From: HOSA_THET2 (O87198)

Key From To Description Tag Condition FTGroup

ACT_SITE 292 292 Proton acceptor H

BINDING 13 13 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 E

BINDING 195 195 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 H

BINDING 197 197 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 H

BINDING 12 12 /ligand="2-oxoglutarate" /ligand_id="ChEBI:CHEBI:16810 R

BINDING 72 72 /ligand="2-oxoglutarate" /ligand_id="ChEBI:CHEBI:16810 H

BINDING 133 133 /ligand="2-oxoglutarate" /ligand_id="ChEBI:CHEBI:16810 R

BINDING 166 166 /ligand="2-oxoglutarate" /ligand_id="ChEBI:CHEBI:16810 T

Additional information [?]