HAMAP rule MF_02228
General rule information
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Accession | MF_02228 |
Dates | 19-SEP-2019 (Created) 26-JAN-2023 (Last updated, Version 6) |
Name | Sulfopropanediol_dehydrog |
Scope | Bacteria; Pseudomonadota |
Template | Q46N53 (HPSN_CUPPJ) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the NAD-dependent oxidation of (R)-2,3-dihydroxypropane-1-sulfonate to (R)-3-sulfolactate. |
Catalytic activity | RHEA:28074: (2R)-3-sulfopropanediol + H2O + 2 NAD(+) = (2R)-3-sulfolactate + 3 H(+) + 2 NADH
EC 1.1.1.308 |
case <FTGroup:1>
Cofactor | Zn(2+) Note: Binds 1 zinc ion per subunit. |
end case
Similarity | Belongs to the histidinol dehydrogenase family. HpsN subfamily. |
Keywords
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case <FTGroup:1>
end case
Gene Ontology
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GO:0016616; Molecular function: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor.
case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
end case
Cross-references
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PROSITE | PS00611; HISOL_DEHYDROGENASE; 1; |
Pfam | PF00815; Histidinol_dh; 1; |
PRINTS | PR00083; HOLDHDRGNASE; 1; |
TIGRFAMs | TIGR00069; hisD; 1; |
PIRSF | PIRSF000099; Histidinol_dh; 1; |
Features
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From: HPSN_CUPPJ (Q46N53) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 318 | 318 | Proton acceptor | E | ||||||||
ACT_SITE | 319 | 319 | Proton acceptor | H | ||||||||
BINDING | 248 | 248 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | [EQ] | 1 | |||||||
BINDING | 251 | 251 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | H | 1 | |||||||
BINDING | 352 | 352 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | D | 1 | |||||||
BINDING | 411 | 411 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | H | 1 | |||||||
BINDING | 118 | 118 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | Y | ||||||||
BINDING | 180 | 180 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | Q | ||||||||
BINDING | 203 | 203 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | N |
Additional information
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Size range | 420-450 amino acids |
Related rules | None |
Fusion | None |