HAMAP rule MF_02228
General rule information
[?]
| Accession | MF_02228 |
| Dates | 19-SEP-2019 (Created)
1-JUN-2023 (Last updated, Version 7) |
| Name | Sulfopropanediol_dehydrog |
| Scope(s) |
Bacteria Pseudomonadota |
| Template(s) | Q46N53 (HPSN_CUPPJ); [ Recover all ] |
| Triggered by |
HAMAP; MF_02228 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | HPSN |
| Protein name | RecName: Full=Sulfopropanediol 3-dehydrogenase; EC=1.1.1.308; AltName: Full=2,3-dihydroxypropane-1-sulfonate 3-dehydrogenase (sulfolactate forming); Short=DHPS 3-dehydrogenase (sulfolactate forming); |
| Gene name | Name=hpsN; |
Comments
[?]
| FUNCTION | Catalyzes the NAD-dependent oxidation of (R)-2,3- dihydroxypropane-1-sulfonate to (R)-3-sulfolactate. |
| CATALYTIC ACTIVITY | Reaction=(2R)-3-sulfopropanediol + H2O + 2 NAD(+) = (2R)-3-sulfolactate + 3 H(+) + 2 NADH; Xref=Rhea:RHEA:28074, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:58738, ChEBI:CHEBI:60997; EC=1.1.1.308; |
| case <FTGroup:1> | |
| COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.; |
| end case | |
| SIMILARITY | Belongs to the histidinol dehydrogenase family. HpsN subfamily. |
Keywords
[?]
| NAD | |
| Oxidoreductase | |
| case <FTGroup:1> | |
| Metal-binding | |
| Zinc | |
| end case | |
Gene Ontology
[?]
| GO:0016616; Molecular function:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | |
| case <FTGroup:1> | |
| GO:0008270; Molecular function:zinc ion binding | |
| end case | |
Cross-references
[?]
| PROSITE | PS00611; HISOL_DEHYDROGENASE; 1; |
| Pfam | PF00815; Histidinol_dh; 1; |
| PRINTS | PR00083; HOLDHDRGNASE; 1; |
| NCBIfam | TIGR00069; hisD; 1; |
| PIRSF | PIRSF000099; Histidinol_dh; 1; |
Features
[?]
| From: HPSN_CUPPJ (Q46N53) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 318 | 318 | /note="Proton acceptor" | E | ||||||||
| ACT_SITE | 319 | 319 | /note="Proton acceptor" | H | ||||||||
| BINDING | 248 | 248 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
[EQ] | 1 | |||||||
| BINDING | 251 | 251 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
H | 1 | |||||||
| BINDING | 352 | 352 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
D | 1 | |||||||
| BINDING | 411 | 411 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
H | 1 | |||||||
| BINDING | 118 | 118 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
Y | ||||||||
| BINDING | 180 | 180 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
Q | ||||||||
| BINDING | 203 | 203 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
N | ||||||||
Additional information
[?]
| Size range | 420-450 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |