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HAMAP rule MF_02228

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General rule information [?]

Accession MF_02228
Dates 19-SEP-2019 (Created)
26-JAN-2023 (Last updated, Version 6)
Name Sulfopropanediol_dehydrog
Scope
Bacteria; Pseudomonadota
Template Q46N53 (HPSN_CUPPJ)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
HPSN
Protein name
RecName: Full=Sulfopropanediol 3-dehydrogenase;
EC 1.1.1.308;
AltName: Full=2,3-dihydroxypropane-1-sulfonate 3-dehydrogenase (sulfolactate forming);
Short=DHPS 3-dehydrogenase (sulfolactate forming);
Gene name
hpsN

Comments [?]

Function Catalyzes the NAD-dependent oxidation of (R)-2,3-dihydroxypropane-1-sulfonate to (R)-3-sulfolactate.
Catalytic activity RHEA:28074: (2R)-3-sulfopropanediol + H2O + 2 NAD(+) = (2R)-3-sulfolactate + 3 H(+) + 2 NADH
EC 1.1.1.308
case <FTGroup:1>
Cofactor Zn(2+)
Note: Binds 1 zinc ion per subunit.
end case
Similarity Belongs to the histidinol dehydrogenase family. HpsN subfamily.

Keywords [?]

NAD
Oxidoreductase
case <FTGroup:1>
Metal-binding
Zinc
end case

Gene Ontology [?]

GO:0016616; Molecular function: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor.
case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
end case

Cross-references [?]

PROSITE PS00611; HISOL_DEHYDROGENASE; 1;
Pfam PF00815; Histidinol_dh; 1;
PRINTS PR00083; HOLDHDRGNASE; 1;
TIGRFAMs TIGR00069; hisD; 1;
PIRSF PIRSF000099; Histidinol_dh; 1;

Features [?]

From: HPSN_CUPPJ (Q46N53)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     318     318       Proton acceptor     E  
ACT_SITE     319     319       Proton acceptor     H  
BINDING     248     248       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     [EQ]   1
BINDING     251     251       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     H   1
BINDING     352     352       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     D   1
BINDING     411     411       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     H   1
BINDING     118     118       /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540     Y  
BINDING     180     180       /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540     Q  
BINDING     203     203       /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540     N  

Additional information [?]

Size range 420-450 amino acids
Related rules None
Fusion None


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