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HAMAP rule MF_02234

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General rule information [?]

Accession MF_02234
Dates 15-OCT-2019 (Created)
19-NOV-2022 (Last updated, Version 7)
Name AOTCase
Scope
Bacteria
Template Q8P8J2 (AOTC_XANCP)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
AOTC
Protein name
RecName: Full=N-acetylornithine carbamoyltransferase;
EC 2.1.3.9;
AltName: Full=N-acetyl-L-ornithine transcarbamylase;
Short=AOTCase;
Short=Acetylornithine transcarbamylase;
Gene name
argF'

Comments [?]

Function Catalyzes the transfer of the carbamoyl group from carbamoyl phosphate to the delta-amino group of N(2)-acetyl-L-ornithine to produce N(2)-acetyl-L-citrulline. This is a step in an alternative arginine biosynthesis pathway.
Catalytic activity RHEA:18609: carbamoyl phosphate + N(2)-acetyl-L-ornithine = H(+) + N(2)-acetyl-L-citrulline + phosphate
EC 2.1.3.9
PhysiologicalDirection=left-to-right (RHEA:18610)
Pathway Amino-acid biosynthesis; L-arginine biosynthesis.
Subunit Homotrimer.
Subcellular location Cytoplasm.
Similarity Belongs to the aspartate/ornithine carbamoyltransferase superfamily. AOTCase family.

Keywords [?]


Gene Ontology [?]

GO:0043857; Molecular function: N-acetylornithine carbamoyltransferase activity.
GO:0006526; Biological process: arginine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00185; OTCace; 1;
PF02729; OTCace_N; 1;
PRINTS PR00100; AOTCASE; 1;

Features [?]

From: AOTC_XANCP (Q8P8J2)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     49     52       /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain     S-x-R-T  
BINDING     148     151       /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain     H-P-C-Q  
BINDING     294     295       /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain     C-L  
BINDING     77     77       /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228" /ligand_note="ligand shared between two neighboring subunits     W  
BINDING     112     112       /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain     R  
BINDING     144     144       /ligand="N(2)-acetyl-L-ornithine" /ligand_id="ChEBI:CHEBI:57805     E  
BINDING     252     252       /ligand="N(2)-acetyl-L-ornithine" /ligand_id="ChEBI:CHEBI:57805     K  
BINDING     295     295       /ligand="N(2)-acetyl-L-ornithine" /ligand_id="ChEBI:CHEBI:57805     L  
BINDING     322     322       /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain     R  
SITE     92     92       Key residue in conferring substrate specificity for N-acetyl-L-ornithine versus N-succinyl-L-ornithine     E  
MOD_RES     302     302       N6-carboxylysine     K  

Additional information [?]

Size range 310-370 amino acids
Related rules None
Fusion None