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Annotation rule MF_02234
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General rule information [?]

Accession MF_02234
Dates 15-OCT-2019 (Created)
20-NOV-2019 (Last updated, Version 3)
Name AOTCase
Scope
Bacteria
Template Q8P8J2 (AOTC_XANCP)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
AOTC
Protein name
RecName: Full=N-acetylornithine carbamoyltransferase;
EC 2.1.3.9;
AltName: Full=N-acetyl-L-ornithine transcarbamylase;
Short=AOTCase;
Short=Acetylornithine transcarbamylase;
Gene name
argF'

Comments [?]

Function Catalyzes the transfer of the carbamoyl group from carbamoyl phosphate to the delta-amino group of N(2)-acetyl-L-ornithine to produce N(2)-acetyl-L-citrulline. This is a step in an alternative arginine biosynthesis pathway.
Catalytic activity RHEA:18609: carbamoyl phosphate + N(2)-acetyl-L-ornithine = H(+) + N(2)-acetyl-L-citrulline + phosphate
EC 2.1.3.9
PhysiologicalDirection=left-to-right (RHEA:18610)
Pathway Amino-acid biosynthesis; L-arginine biosynthesis.
Subunit Homotrimer.
Subcellular location Cytoplasm.
Similarity Belongs to the aspartate/ornithine carbamoyltransferase superfamily. AOTCase family.

Keywords [?]

Amino-acid biosynthesis
Arginine biosynthesis
Cytoplasm
Transferase

Gene Ontology [?]

GO:0043857; Molecular function: N-acetylornithine carbamoyltransferase activity.
GO:0006526; Biological process: arginine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00185; OTCace; 1;
PF02729; OTCace_N; 1;
PRINTS PR00100; AOTCASE; 1;

Features [?]

From: AOTC_XANCP (Q8P8J2)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     49     52       Carbamoyl phosphate binding     S-x-R-T  
REGION     148     151       Carbamoyl phosphate binding     H-P-C-Q  
REGION     294     295       Carbamoyl phosphate binding     C-L  
BINDING     77     77       Carbamoyl phosphate; shared with neighboring subunit     W  
BINDING     112     112       Carbamoyl phosphate     R  
BINDING     144     144       N(2)-acetyl-L-ornithine     E  
BINDING     252     252       N(2)-acetyl-L-ornithine     K  
BINDING     295     295       N(2)-acetyl-L-ornithine; via carbonyl oxygen     L  
BINDING     322     322       Carbamoyl phosphate     R  
SITE     92     92       Key residue in conferring substrate specificity for N-acetyl-L-ornithine versus N-succinyl-L-ornithine     E  
MOD_RES     302     302       N6-carboxylysine     K  

Additional information [?]

Size range 310-370 amino acids
Related rules None
Fusion None


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