HAMAP rule MF_02234

General rule information [?]

Accession	MF_02234
Dates	15-OCT-2019 (Created) 19-NOV-2022 (Last updated, Version 7)

Name

AOTCase

Scope

Bacteria

Template

Q8P8J2 (AOTC_XANCP)

Triggered by

HAMAP; MF_02234 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

AOTC

Protein name

RecName:		Full=N-acetylornithine carbamoyltransferase;
		EC 2.1.3.9;
AltName:		Full=N-acetyl-L-ornithine transcarbamylase;
		Short=AOTCase;
		Short=Acetylornithine transcarbamylase;

Gene name

argF'

Comments [?]

Function	Catalyzes the transfer of the carbamoyl group from carbamoyl phosphate to the delta-amino group of N(2)-acetyl-L-ornithine to produce N(2)-acetyl-L-citrulline. This is a step in an alternative arginine biosynthesis pathway.
Catalytic activity	RHEA:18609: carbamoyl phosphate + N(2)-acetyl-L-ornithine = H(+) + N(2)-acetyl-L-citrulline + phosphate EC 2.1.3.9 PhysiologicalDirection=left-to-right (RHEA:18610)
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis.
Subunit	Homotrimer.
Subcellular location	Cytoplasm.
Similarity	Belongs to the aspartate/ornithine carbamoyltransferase superfamily. AOTCase family.

Keywords [?]

Amino-acid biosynthesis
Arginine biosynthesis
Cytoplasm
Transferase

Gene Ontology [?]

GO:0043857; Molecular function: N-acetylornithine carbamoyltransferase activity.
GO:0006526; Biological process: arginine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF00185; OTCace; 1;
	PF02729; OTCace_N; 1;
PRINTS	PR00100; AOTCASE; 1;

Features [?]

From: AOTC_XANCP (Q8P8J2)

Key From To Description Tag Condition FTGroup

BINDING 49 52 /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain S-x-R-T

BINDING 148 151 /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain H-P-C-Q

BINDING 294 295 /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain C-L

BINDING 77 77 /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228" /ligand_note="ligand shared between two neighboring subunits W

BINDING 112 112 /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain R

BINDING 144 144 /ligand="N(2)-acetyl-L-ornithine" /ligand_id="ChEBI:CHEBI:57805 E

BINDING 252 252 /ligand="N(2)-acetyl-L-ornithine" /ligand_id="ChEBI:CHEBI:57805 K

BINDING 295 295 /ligand="N(2)-acetyl-L-ornithine" /ligand_id="ChEBI:CHEBI:57805 L

BINDING 322 322 /ligand="carbamoyl phosphate" /ligand_id="ChEBI:CHEBI:58228" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain R

SITE 92 92 Key residue in conferring substrate specificity for N-acetyl-L-ornithine versus N-succinyl-L-ornithine E

MOD_RES 302 302 N6-carboxylysine K

Additional information [?]

Size range	310-370 amino acids
Related rules	None
Fusion	None

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