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HAMAP rule MF_02234

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General rule information [?]

Accession MF_02234
Dates 15-OCT-2019 (Created)
19-NOV-2022 (Last updated, Version 7)
Name AOTCase
Scope(s) Bacteria
Template(s) Q8P8J2 (AOTC_XANCP); [ Recover all ]
Triggered by HAMAP; MF_02234 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier AOTC
Protein name RecName: Full=N-acetylornithine carbamoyltransferase;
                 EC=2.1.3.9;
AltName: Full=N-acetyl-L-ornithine transcarbamylase;
                 Short=AOTCase;
                 Short=Acetylornithine transcarbamylase;
Gene name Name=argF';

Comments [?]

FUNCTIONCatalyzes the transfer of the carbamoyl group from carbamoyl phosphate to the delta-amino group of N(2)-acetyl-L-ornithine to produce N(2)-acetyl-L-citrulline. This is a step in an alternative arginine biosynthesis pathway.
CATALYTIC ACTIVITY Reaction=carbamoyl phosphate + N(2)-acetyl-L-ornithine = H(+) + N(2)- acetyl-L-citrulline + phosphate; Xref=Rhea:RHEA:18609, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57805, ChEBI:CHEBI:58228, ChEBI:CHEBI:58765; EC=2.1.3.9; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18610;
PATHWAYAmino-acid biosynthesis; L-arginine biosynthesis.
SUBUNITHomotrimer.
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the aspartate/ornithine carbamoyltransferase superfamily. AOTCase family.

Keywords [?]


Gene Ontology [?]

GO:0043857; Molecular function:N-acetylornithine carbamoyltransferase activity
GO:0006526; Biological process:arginine biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF00185; OTCace; 1;
Pfam PF02729; OTCace_N; 1;
PRINTS PR00100; AOTCASE; 1;

Features [?]

From: AOTC_XANCP (Q8P8J2)
Key From To Description Tag Condition FTGroup
BINDING 49 52 /ligand="carbamoyl phosphate"
/ligand_id="ChEBI:CHEBI:58228"
/ligand_note="ligand shared between two neighboring subunits"
/note="in other chain"
S-x-R-T
BINDING 148 151 /ligand="carbamoyl phosphate"
/ligand_id="ChEBI:CHEBI:58228"
/ligand_note="ligand shared between two neighboring subunits"
/note="in other chain"
H-P-C-Q
BINDING 294 295 /ligand="carbamoyl phosphate"
/ligand_id="ChEBI:CHEBI:58228"
/ligand_note="ligand shared between two neighboring subunits"
/note="in other chain"
C-L
BINDING 77 77 /ligand="carbamoyl phosphate"
/ligand_id="ChEBI:CHEBI:58228"
/ligand_note="ligand shared between two neighboring subunits"
W
BINDING 112 112 /ligand="carbamoyl phosphate"
/ligand_id="ChEBI:CHEBI:58228"
/ligand_note="ligand shared between two neighboring subunits"
/note="in other chain"
R
BINDING 144 144 /ligand="N(2)-acetyl-L-ornithine"
/ligand_id="ChEBI:CHEBI:57805"
E
BINDING 252 252 /ligand="N(2)-acetyl-L-ornithine"
/ligand_id="ChEBI:CHEBI:57805"
K
BINDING 295 295 /ligand="N(2)-acetyl-L-ornithine"
/ligand_id="ChEBI:CHEBI:57805"
L
BINDING 322 322 /ligand="carbamoyl phosphate"
/ligand_id="ChEBI:CHEBI:58228"
/ligand_note="ligand shared between two neighboring subunits"
/note="in other chain"
R
SITE 92 92 /note="Key residue in conferring substrate specificity for N-acetyl-L-ornithine versus N-succinyl-L-ornithine" E
MOD_RES 302 302 /note="N6-carboxylysine" K

Additional information [?]

Size range 310-370 amino acids
Related rules None
Fusion Nter: None Cter: None



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