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Annotation rule MF_02234 |
Accession | MF_02234 |
Dates | 15-OCT-2019 (Created) 20-NOV-2019 (Last updated, Version 3) |
Name | AOTCase |
Scope | Bacteria |
Template | Q8P8J2 (AOTC_XANCP) |
Triggered by |
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Protein name |
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Gene name |
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Function | Catalyzes the transfer of the carbamoyl group from carbamoyl phosphate to the delta-amino group of N(2)-acetyl-L-ornithine to produce N(2)-acetyl-L-citrulline. This is a step in an alternative arginine biosynthesis pathway. |
Catalytic activity | RHEA:18609: carbamoyl phosphate + N(2)-acetyl-L-ornithine = H(+) + N(2)-acetyl-L-citrulline + phosphate
EC 2.1.3.9 PhysiologicalDirection=left-to-right (RHEA:18610) |
Pathway | Amino-acid biosynthesis; L-arginine biosynthesis. |
Subunit | Homotrimer. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the aspartate/ornithine carbamoyltransferase superfamily. AOTCase family. |
From: AOTC_XANCP (Q8P8J2) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
REGION | 49 | 52 | Carbamoyl phosphate binding | S-x-R-T | ||||||||
REGION | 148 | 151 | Carbamoyl phosphate binding | H-P-C-Q | ||||||||
REGION | 294 | 295 | Carbamoyl phosphate binding | C-L | ||||||||
BINDING | 77 | 77 | Carbamoyl phosphate; shared with neighboring subunit | W | ||||||||
BINDING | 112 | 112 | Carbamoyl phosphate | R | ||||||||
BINDING | 144 | 144 | N(2)-acetyl-L-ornithine | E | ||||||||
BINDING | 252 | 252 | N(2)-acetyl-L-ornithine | K | ||||||||
BINDING | 295 | 295 | N(2)-acetyl-L-ornithine; via carbonyl oxygen | L | ||||||||
BINDING | 322 | 322 | Carbamoyl phosphate | R | ||||||||
SITE | 92 | 92 | Key residue in conferring substrate specificity for N-acetyl-L-ornithine versus N-succinyl-L-ornithine | E | ||||||||
MOD_RES | 302 | 302 | N6-carboxylysine | K |
Size range | 310-370 amino acids |
Related rules | None |
Fusion | None |