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Annotation rule MF_02246
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General rule information [?]

Accession MF_02246
Dates 16-FEB-2021 (Created)
19-FEB-2021 (Last updated, Version 2)
Name Gua_Ino_kinase
Scope
Bacteria; Proteobacteria
Template P0AEW6 (INGK_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
INGK
Protein name
RecName: Full=Guanosine-inosine kinase;
EC 2.7.1.73;
Gene name
gsk

Comments [?]

Function Catalyzes the phosphorylation of guanosine and inosine to GMP and IMP, respectively.
Catalytic activity RHEA:27710: ATP + guanosine = ADP + GMP + H(+)
EC 2.7.1.73
RHEA:21140: ATP + inosine = ADP + H(+) + IMP
EC 2.7.1.73
Cofactor Mg(2+)
Pathway Purine metabolism; IMP biosynthesis via salvage pathway; IMP from inosine: step 1/1.
Purine metabolism; GMP biosynthesis via salvage pathway.
Similarity Belongs to the carbohydrate kinase PfkB family.

Keywords [?]


Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0008906; Molecular function: inosine kinase activity.
GO:0032263; Biological process: GMP salvage.
GO:0032264; Biological process: IMP salvage.

Cross-references [?]

PROSITE PS00583; PFKB_KINASES_1; 1;
PS00584; PFKB_KINASES_2; 1;
Pfam PF00294; PfkB; 1;

Features [?]

From: INGK_ECOLI (P0AEW6)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND (Optional)     40     45       GMP     D-[QE]-T-[LI]-V-D  
NP_BIND (Optional)     93     97       GMP     G-[TA]-[IV]-[GA]-N  
NP_BIND (Optional)     284     289       ATP     T-x-G-x-x-G  
BINDING (Optional)     198     198       GMP     R  
BINDING (Optional)     357     357       ATP; via amide nitrogen     G  
BINDING (Optional)     402     402       ATP     N  

Additional information [?]

Size range 400-480 amino acids
Related rules None
Fusion None