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HAMAP rule MF_02246

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General rule information [?]

Accession MF_02246
Dates 16-FEB-2021 (Created)
26-JAN-2023 (Last updated, Version 5)
Name Gua_Ino_kinase
Scope(s) Bacteria
Pseudomonadota
Template(s) P0AEW6 (INGK_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_02246 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier INGK
Protein name RecName: Full=Guanosine-inosine kinase;
                 EC=2.7.1.73;
Gene name Name=gsk;

Comments [?]

FUNCTIONCatalyzes the phosphorylation of guanosine and inosine to GMP and IMP, respectively.
CATALYTIC ACTIVITY Reaction=ATP + guanosine = ADP + GMP + H(+); Xref=Rhea:RHEA:27710, ChEBI:CHEBI:15378, ChEBI:CHEBI:16750, ChEBI:CHEBI:30616, ChEBI:CHEBI:58115, ChEBI:CHEBI:456216; EC=2.7.1.73;
CATALYTIC ACTIVITY Reaction=ATP + inosine = ADP + H(+) + IMP; Xref=Rhea:RHEA:21140, ChEBI:CHEBI:15378, ChEBI:CHEBI:17596, ChEBI:CHEBI:30616, ChEBI:CHEBI:58053, ChEBI:CHEBI:456216; EC=2.7.1.73;
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
PATHWAYPurine metabolism; IMP biosynthesis via salvage pathway; IMP from inosine: step 1/1.
PATHWAYPurine metabolism; GMP biosynthesis via salvage pathway.
SIMILARITYBelongs to the carbohydrate kinase PfkB family.

Keywords [?]


Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0008906; Molecular function:inosine kinase activity
GO:0032263; Biological process:GMP salvage
GO:0032264; Biological process:IMP salvage

Cross-references [?]

PROSITE PS00583; PFKB_KINASES_1; 1;
PROSITE PS00584; PFKB_KINASES_2; 1;
Pfam PF00294; PfkB; 1;

Features [?]

From: INGK_ECOLI (P0AEW6)
Key From To Description Tag Condition FTGroup
BINDING 40 45 /ligand="GMP"
/ligand_id="ChEBI:CHEBI:58115"
D-[QE]-T-[LI]-V-D
BINDING 93 97 /ligand="GMP"
/ligand_id="ChEBI:CHEBI:58115"
G-[TA]-[IV]-[GA]-N
BINDING 284 289 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
T-x-G-x-x-G
BINDING 198 198 /ligand="GMP"
/ligand_id="ChEBI:CHEBI:58115"
R
BINDING 357 357 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
G
BINDING 402 402 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
N

Additional information [?]

Size range 400-480 amino acids
Related rules None
Fusion Nter: None Cter: None



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