HAMAP rule MF_02246
General rule information
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| Accession | MF_02246 |
| Dates | 16-FEB-2021 (Created)
26-JAN-2023 (Last updated, Version 5) |
| Name | Gua_Ino_kinase |
| Scope(s) |
Bacteria Pseudomonadota |
| Template(s) | P0AEW6 (INGK_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_02246 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | INGK |
| Protein name | RecName: Full=Guanosine-inosine kinase; EC=2.7.1.73; |
| Gene name | Name=gsk; |
Comments
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| FUNCTION | Catalyzes the phosphorylation of guanosine and inosine to GMP and IMP, respectively. |
| CATALYTIC ACTIVITY | Reaction=ATP + guanosine = ADP + GMP + H(+); Xref=Rhea:RHEA:27710, ChEBI:CHEBI:15378, ChEBI:CHEBI:16750, ChEBI:CHEBI:30616, ChEBI:CHEBI:58115, ChEBI:CHEBI:456216; EC=2.7.1.73; |
| CATALYTIC ACTIVITY | Reaction=ATP + inosine = ADP + H(+) + IMP; Xref=Rhea:RHEA:21140, ChEBI:CHEBI:15378, ChEBI:CHEBI:17596, ChEBI:CHEBI:30616, ChEBI:CHEBI:58053, ChEBI:CHEBI:456216; EC=2.7.1.73; |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
| PATHWAY | Purine metabolism; IMP biosynthesis via salvage pathway; IMP from inosine: step 1/1. |
| PATHWAY | Purine metabolism; GMP biosynthesis via salvage pathway. |
| SIMILARITY | Belongs to the carbohydrate kinase PfkB family. |
Keywords
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Gene Ontology
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| GO:0005524; Molecular function:ATP binding |
| GO:0008906; Molecular function:inosine kinase activity |
| GO:0032263; Biological process:GMP salvage |
| GO:0032264; Biological process:IMP salvage |
Cross-references
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Features
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| From: INGK_ECOLI (P0AEW6) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 40 | 45 | /ligand="GMP" /ligand_id="ChEBI:CHEBI:58115" |
D-[QE]-T-[LI]-V-D | ||||||||
| BINDING | 93 | 97 | /ligand="GMP" /ligand_id="ChEBI:CHEBI:58115" |
G-[TA]-[IV]-[GA]-N | ||||||||
| BINDING | 284 | 289 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
T-x-G-x-x-G | ||||||||
| BINDING | 198 | 198 | /ligand="GMP" /ligand_id="ChEBI:CHEBI:58115" |
R | ||||||||
| BINDING | 357 | 357 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
G | ||||||||
| BINDING | 402 | 402 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
N | ||||||||
Additional information
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| Size range | 400-480 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |